Conserved Protein Domain Family
GlcNAc-1-P_transferase

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cd06436: GlcNAc-1-P_transferase 
N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine.
N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.
Statistics
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PSSM-Id: 133058
View PSSM: cd06436
Aligned: 7 rows
Threshold Bit Score: 276.957
Threshold Setting Gi: 94984622
Created: 9-Jun-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
DXD motif
Feature 1:DXD motif
Evidence:
  • Comment:DXD motif in the catalytic site could be in binding the metal ion that is used to corordinate the phosphates of the NDP-sugar in the active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 50955623   45 FFVPCRDEAAVIERTVAAARrdf-pavHVWVVDDHSDDDTgrivea-iarrdSRVHLVTRRRPEARTGKGDALNAAydal 122
gi 94984622   46 FLIPALNEAQVIEATVHNLRrvs-pnsRVAVIDDDSDDATavlvsa-laasdPNVLLLRRVAPEARQGKGRALNWAatql 123
gi 15673247  439 VLIPCLNEELVIQTTLKSILkndyenlVVTVIDDASDDRSlekis---eiqdSRLNVLRRIKPNAQKGKGTALNWAyyqi 515
gi 50955035   64 VMIPCLNEEAVIGRTVATLVgnt-rttTTIVIDDGSEDTTaqiar---eeggEKVIVLRRELPNARQGKGVALNQAyeli 139
gi 7739685    77 FLLACLNEEKVLAESLARITalparntLALVIDDASDDRTadiaraacaahpGTVHLLRRQLPNARKGKGAALNAGiahl 156
gi 194468095  56 VIVPCFNEAAVIQRTIKCLLrfk--qfAIVVVDDASSDDSvgqik---qitnSRVHLLRRHLPNAHTGKGDVLNFAldyi 130
gi 108805419  43 LLVPALNEERVISRTLSSLLrlr-gnfLVLVIDDASEDGTvaavr--pflenPRVRLLRQPPEEARRGKGHVLNAGvgai 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           ###                                                          
gi 50955623  123 nafl-padadrerIIVMVLDADGelsaralammasaevfldpgVGGAQVVVWMKNrherrpkpghgwlgnlfgRFLVKLQ 201
gi 94984622  124 lqrlraegadlsrEVFAVIDADGrigpellee--arqalgdpqVMGAQARVRIRQsvgrlc------pqnvigRMLEQQQ 195
gi 15673247  516 seqiqeagiapedVLIAIIDADTkldnnyfekv-nmafnhdakLTGLQSKVRVAN------------------LIKDASQ 576
gi 50955035  140 kklvtergenperVLILVMDADGrlsngafsh--ilplfedpqVAGVQLAVRIRNra---------------tNFLTWFQ 202
gi 7739685   157 rssglldgrdprdVIVCVVDADGrldphvvqa--vdpyfdnprTGGTQIGVRMYNrh---------------kGLLARLQ 219
gi 194468095 131 cqitirqrvpfekVIIGVVDADAqlaenalqr--lnayfssprTNITQMRVKMYPhf---------------kNWLQILQ 193
gi 108805419 120 rrmriseyfgaenIIVTVFDADArvepgflda--vapcfadprVAGVQSAVRMYNad---------------aNLLTFWQ 182
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                               
gi 50955623  202 DIEFRtiiaamQSLRARTGTVGLGGNGQFARLSVLDlir-ashDRPWHG-ALLED 254
gi 94984622  196 DVEFFitr-hlQVLRSRWHTVALCGNGQFMRASYVAgqf-argLEPWPD-VLLED 247
gi 15673247  577 DLEFSeiinatQMFRTLTNTVAFGGNGQFCKLSTLQal----nEDPWTD-SLVED 626
gi 50955035  203 DFQFWamsavtQFGRAKTGTVSLGGNGQFTRLSALLal----kNQPWSD-SLTED 252
gi 7739685   220 DMEFViygdifQSARRYIGSVGMGGNGQFMRLAALDtllgpdgSGPWSD-SLTED 273
gi 194468095 194 DIEFFsvnhmaQIMRMYTKTVGLSGNGQFFRLAPIIdk---igAHPWGN-ALLDD 244
gi 108805419 183 NLEFAiwgrvmCRAKNLLGSATLGGNGQCVRLSALEgl----gEEPWQAaSLTED 233

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