Conserved Protein Domain Family
CESA_CaSu_A2

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cd06437: CESA_CaSu_A2 
Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex.
Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.
Statistics
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PSSM-Id: 133059
View PSSM: cd06437
Aligned: 12 rows
Threshold Bit Score: 383.199
Threshold Setting Gi: 182677282
Created: 6-Jun-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
DXD motif
Feature 1:DXD motif
Evidence:
  • Comment:DXD motif in the catalytic site could be in binding the metal ion that is used to corordinate the phosphates of the NDP-sugar in the active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 37523798   38 PLVTVQLPVFNElYVCRRLLAATCALDYPreaLHIQVLDDSTDEtvqllaaaieeqr--rlgfsiehlhrkeRHGFKAGA 115
gi 94969931   90 PRVTVQLPIFNEqYVIDRLVEAVCKLDYPkdkLDIQVLDDSTDEtvevarevverya--algnpisyihrtnRHGFKAGA 167
gi 86131961   54 PLVTIQLPVYNElYVMERLLDNIALLDYPkekLEIQVLDDSTDEsfertknhierlk--nqgldikhvtredRSGFKAGA 131
gi 45658787   57 PVVTVQLPIFNEyYVVDRLIETTVALKYPkdkLEIQLLDDSTDEtveksrnlinhykslgfdihhlhrsgaeRTGHKAGA 136
gi 21536839  119 PMVLVQIPMYNEkEVCEQSIAAACKISWPsnrIIIQVLDDSTDPaskelvkkecdrws-kegvnitfeirdnRNGYKAGA 197
gi 30249313   74 PSVSVLLPVHNEsFVVERLIDAACRLRYPadlLEILVLDDSSDDtsrlararveqya--argvnirhvcrndRQGYKAGN 151
gi 118194836  50 PSVTIQLPIYNEkYVAARLISAVCDMDYPkdrLRIMVLDDSDDDtvdmvggivkeyr--drglqiehvrrgtRRGYKAGA 127
gi 116055726 170 PMVVIQLPMFNEtDVCVHAIECAREMEWPrskLLIQILDDSTCPetratieealevck-eqgvhtqyrwrsdRTGFKAGA 248
gi 89892733   89 PMVLVQIPMFNErEVYQLSIQAACGLSWPgdrMIIQVLDDSTDQttrdlvqmecqrwa-skginiryetrpnRKGYKAGA 167
gi 156342928   5 PFVTIQLPIFNEkYVVERLLHSVAALDYPkekLEVQVLDDSTDDsvietarlinkha--lsglnikhirrenRVGFKAGA 82
gi 109628385  99 PMVLVQIPMYNErEVYQLSIGAACALSWPsnrVIIQVLDDSTDLtikdlvemecqkwa-skginikyeirgnRNGYKAGA 177
gi 182677282  64 PHVLIQIPVFNEaEMVAEALQAAAALQWPrdrLHIQLLDDSTDEtstiaqrivlnlr--aqgtdvlhlrradRSGYKAGA 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           ###                                                          
gi 37523798  116 LAAAtpla---ngeYIAIFDADFlpppdwlkr-alvhfadgrVGLVQTRWGHTNpgySLLTRLQALGIDgHFAVEQqarc 191
gi 94969931  168 LQEGmavc---kgeFIAIFDADFvppadflqk-cihhfaepeIGMVQTRWTHLNrnySFLTEVEAILLDgHFVLEHggrs 243
gi 86131961  132 LKEGlkva---kgeYIAIFDADFlpepnwlqr-tvpyfkdrnIGVVQTRWGHINreySLLTRVQAFALDaHFTLEQvgrn 207
gi 45658787  137 LEAGmkva---rgeYIAIFDADFmpnpdflik-tvpyfddpqIGMVQVRWGHINadyNVLTKAQSFGIDgHFMIEQvarn 212
gi 21536839  198 LREGmrhsyvkqcdYVAIFDADFqpdpdflhrtvpflihnpkLALVQGRWEFVNagqCMMTRLQEMSLSyHFTIEQqvgs 277
gi 30249313  152 LAHGihqa---sgeFFAIFDADFvpppdfllk-tipyfrdpqLGFLQTGIGYENknkSFLTRFQAMEMG-HQQYVTvgls 226
gi 118194836 128 LQHAmkst---dteYVAIFDADFippkeflrk-tlphfaradMGFVQCRWGHVNedySTITQAQALSLDfHFLIEQkaks 203
gi 116055726 249 MHDAmddi--veydYVCVFDADFspdpdflmktvpwihsnnhVGFVQARWTYINsseNLLTRVQSISLNyHIRCEQfarf 326
gi 89892733  168 LRQGmkwpyvqtcdYVAIFDADFqpepeflqrtvpflvhnsdLALVQARWKFVNaneCLMTKMQEVSLNyHFSVEQrvgs 247
gi 156342928  83 LKEGlida---kgeFIVIFDADFvpkpnwlqe-tipyfknekVGVVQTRWGHINrnfSILTKIQAFALDaHFTLEQvgrn 158
gi 109628385 178 LKEGmkhsyvrecdYVVIFDADFqpdrdflsrtipflvhnpeLALVQARWKFVNadeCLMTRMQEMSLDyHFTVEQevgs 257
gi 182677282 142 LAAGmarc---dapYVAIFDVDFrppsnwlravvpmliadkkAGFVQSRCEFSNyatNWLTRIQGLMMDaHYTMEQatry 218
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                                      
gi 37523798  192 angyyfnfNGTAGVWRKRAIEAGGGWQADTLAEDLDLsyrsqlAGWKAVYDGRIVAPAELPVSMAAYKMQQYRWAKGS 269
gi 94969931  244 rkgvffnfNGTAGMWRKQAIEEAGGWQHDTLTEDTDLsyraqvKGWRFKYLQDVECPAELPIEMTAFKTQQARWAKGL 321
gi 86131961  208 skghfinfNGTAGLWRKQCIEDAGNWEGDTLTEDLDLsyraqlKNWKFKYLEDVKTPAELPVVISAARSQQFRWNKGG 285
gi 45658787  213 gshlwmnfNGTAGIWKKECIIDSGGWEHDTLTEDFDLsyraemKGWKFRYFKDIECKAEIPAMISAYKSQQFRWCKGS 290
gi 21536839  278 stfaffgfNGTAGVWRISALNESGGWNDQTTVEDMDLavratlRGWKFLYIDDLKVKSELPCSFKALRSQQHRWTCGP 355
gi 30249313  227 eegdmaslSGSSCVWRKSCVEVLGGWNTSMVTEDVDLgyraqfGEWKYAYLRDVVSMSLLPESVSAFRVQRERWGRGL 304
gi 118194836 204 nsrlfmnfNGTAGIWKRECIEDAGGWHTATLVEDLDLsyraqmKGWKCTFLPDVVIDAELPVQMNAAKRQQFRWAKGS 281
gi 116055726 327 sanlffnfNGTAGIWRRTCIVDSGGWNHRTTVEDLDLslrahlRGWKFIFLDDVTCLNEIPAQYDAYRKQQHRWSAGP 404
gi 89892733  248 atygffgfNGTAGVWRIRAMEEAGGWNDRTTVEDMDLavraslCGWKFVYIHDLEVKNELPSTFKAFRFQQHRWSCGP 325
gi 156342928 159 sknhfinfNGTAGAWRKSCIIDAGNWESDTLTEDLDLsyraqlKKWQFVYLEDVETPAELPAVLSAARSQQFRWNKGG 236
gi 109628385 258 athaffgfNGTAGVWRIKALNEAGGWKDRTTVEDMDLavraslRGWKFVFVGDLGVKNELPSTFKAYRYQQHRWSCGP 335
gi 182677282 219 ragwlfqfNGTAGLWRREAIEAAGGWSADSLCEDLDLtvrarvAGWHGVFTMEPVVPGLVPEKVRHWRVQQRRWSTGF 296

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