Conserved Protein Domain Family
EpsO_like

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cd06438: EpsO_like 
EpsO protein participates in the methanolan synthesis.
The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.
Statistics
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PSSM-Id: 133060
View PSSM: cd06438
Aligned: 25 rows
Threshold Bit Score: 120.784
Threshold Setting Gi: 148555289
Created: 9-Jun-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
DXD motif
Feature 1:DXD motif
Evidence:
  • Comment:DXD motif in the catalytic site could be in binding the metal ion that is used to corordinate the phosphates of the NDP-sugar in the active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 85717071   51 VIVPAHDESGGIIPTISDIKsqls--sndRLIVVADNCTDDTAAVAESAGAe-VIARNDLEKIGKGYALGWGishlr--- 124
gi 167461511  15 ILICAHNEEQVVGQLVQNLDsldyprnlyDIYVIADNCTDSTALVARQNGTl-VLERHDPTKKSKGYELEWAfeqlwnme 93
gi 121535786  48 IIIAAHNEEQVIGQLVENLQvlryprelyDIFVVADNCKDRTAQIARNAGAi-VYERFNLEQRGKGYAMEWMfaklfr-- 124
gi 153004277  43 VLVPAHDEAAVVGEAVRALTlldyprrmfRLVVVADNCTDDTAERARAAGAdeVLERTDPVQTGKGYALRWAlerva--- 119
gi 189347341  47 VLIPAHNEEEGIARTVRNVLacdypanrrYIFVIADNCTDSTAETARNAGAt-VCERTDEINRGKGQALDWFlrkqkn-- 123
gi 192810276  45 VLVAAHNEEQVVGALMENLKqlnypkhlyDVFVICDNCTDRTAEIVRAHGMn-ACVRTNQNLRGKGYAIEWMlkelwa-- 121
gi 18145735   48 MLVAAHNEEVVIENLVESLKhldypkelyDIFVIADNCTDNTAKIARAAGAn-VFERFNKEKRGKGFALEWMfdkifk-- 124
gi 154483158  66 ILIPARNEETVIGNLINSIKkqdypqdliTIFVVADNCTDNTAQIAREKGAi-CYEHHNPDERTKGFALKYLfeqiqrd- 143
gi 154496593  53 AVISARNEEGVIGELIQCLKqqnypsdllDVYVIADNCTDDTAGAARAAGAi-VYEREDQRLKGKGYALDWLfhhlaa-- 129
gi 46190494   48 VLISARNEEKVIGNLIGSIRdqtypsnliDIWLVADNCTDNTADVVRSLGCh-VVERHNLELVGKGYALTYLlghmldi- 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ###                                                                 
gi 85717071  125 --kdppDFVVVFDADCriq-sdaLERLTDICGKLQRPVQACFLMRSPDnsPIDHRFAEFAFLLRNWIRPFGLSNlncpvq 201
gi 167461511  94 argttyDAVLVLDADNlvt-pntLKVLNQRIVSGAEVLQLYLDSKNPKd-SWISKSYAYAYWATNRIYQLAREKlglsaq 171
gi 121535786 125 -mkrkyDAVVVFDADNlvh-pnfLLEMNNRLCKGEKVIQGYLDAKNPHd-TWIAGTFAISFWVVNHIWHLAKYNiglssv 201
gi 153004277 120 -lrwtpDAVCVFDADNvmt-pnfLSVMNARLAAGAHVVQGYLDTKNPDd-SWVTKAISTGYSVSSRLFQLSRENvgmsaa 196
gi 189347341 124 -iykdtDAITIIDADVnpdtgylREISLSLSQLDTQAIQAYNGVSNPKs-GWRPGLIDAAFNVFNHLRMAGSCQlsgtcv 201
gi 192810276 122 -mprqyDAVVMFDADNlad-pnfLNEMNNDLCSGARVIQGYIDTKNPEd-SWITASYGVSYWYINRLWQLSRSNlnmanf 198
gi 18145735  125 -mdthyDGIAVFDADNlvd-knfLKEMNNKMCEGFKVVQGYIDSKNPQd-SWITESYAIAFTSANRMLQLAKSNiglsaq 201
gi 154483158 144 ygitsfEGYFIFDSDNllk-kdyISRMNDSFDAGEKIITSYRATKNFSe-NWIASTYALHWLRSIRTRHRARSFlhlatn 221
gi 154496593 130 eerdvyDAYLIFDADNlvdknfvREMNRVFDTGKYDALTSYRNSKNFGd-NWISAGYSIWFLREARFLSYPRMLlgsnch 208
gi 46190494  126 gvaddyEAYFVFDADNkld-khyFEEMNKAFCSGFKILTSYRNSVNLAd-NWVSSGSALWFIRESRFLSNSRMIlgssch 203
                        170       180       190
                 ....*....|....*....|....*....|
Feature 1                                      
gi 85717071  202 LMGTGMIFPWMTIRd-aPLASGHLVEDLKL 230
gi 167461511 172 LGGTGMCFKTSVLKn-iGWGTESLTEDLEY 200
gi 121535786 202 LGGTGMCIATDVLQk-fGWGATCLTEDMEF 230
gi 153004277 197 LGGTGYCIRVATLRa-fPPDPACVTDDAEL 225
gi 189347341 202 LKGNGMAFRTALLQr-tGWPCHSIVEDMEF 230
gi 192810276 199 LGGTGMCFETNLLKe-iGWGATSLVEDLEF 227
gi 18145735  202 IGGTGFVIDTATLKk-lGWGATCLTEDLEF 230
gi 154483158 222 IQGTGFLFASEIVKd--GWKYTSLTEDRAL 249
gi 154496593 209 VSGTGFLVSAKVIRengGWPYHLLTEDIEF 238
gi 46190494  204 VGGTGFMFSREVMKrnkGWKFHLLTEDLEF 233

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