Conserved Protein Domain Family
D-Ser-dehyd

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cd06447: D-Ser-dehyd 
D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive antagonist of beta-alanine in the biosynthetic pathway to pentothenate and coenzyme A. D-serine dehydratase is different from other pyridoxal-5'-phosphate-dependent enzymes in that it catalyzes alpha, beta-elimination reactions on amino acids.
Statistics
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PSSM-Id: 107208
View PSSM: cd06447
Aligned: 11 rows
Threshold Bit Score: 668.283
Threshold Setting Gi: 123533127
Created: 10-Jul-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
catalyticpyridoxal
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:based on similarity to tryptophan synthase beta -like proteins with structure
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 77416591   23 VFWVNPNmekyetaikdsplseenvkdAEERLKRFASYIAKVFPETketkgiiESPLLKIPSMkqaleknyeqpilgeLL 102
gi 123577205  14 MFWQNPNklsadealarinfsfddifeAQKRLQRFAPLIKKLFPETeng--iiESPLAEIPRMkqeieklyggkihgrLF 91
gi 123624073  20 LLWVNPRlgqplpasa---psleliaaAEARLARCAPLMAALFPELasshgqvESQLMPATGLqyalge----gaegaWF 92
gi 122423007  25 TTWFNPGttslaeglpyvglteqdvqdAHARLSRFAPYLAKAFPETaaaggiiESELVAIPAMqkrlekeyhqpiagqLL 104
gi 23396844   22 VGWTNPKemnyteyekklplkdqelkeAEERLKRFAPFIKKVFPETeetygiiESPLEEIFNMqkelekkyhteilgkLY 101
gi 150416134  26 IFWKNPNygdelpdld---vnretifqANRRLERFAPYLESVFSDTkrskgiiESPIQRMDSIkdlls------vkgsLL 96
gi 122265063  23 IFWKNLNykkeaelp----vgvehifdAEARFQRFAPYFEVAFPETlpthgilESPLLKMDKMkavlnaeaqnqvkgdLY 98
gi 1711354    26 VFWANSGkkegplpra--dewateiaeAEKRMQRFAPYIAEVFPETkgakgiiESPLFEVQHMkgkleaayqqpfpgrWL 103
gi 123533127  20 IVWLNRNyqnpasapa--tpnvdalyaAEARLKRFAPLLQRLFPELepshgliESSLIQADRLnnrin-----pvgglLF 92
gi 115305735  22 IVWQNPDygkradlp----ltradifdAVARWERFAPFLAVAFPETaamngiiESPLLPLEQMkpawealnhqslagqLY 97
gi 88941984   26 CAWFNPAaapaaealpdvglgaadiadASARLRRFAPYISRAFPETaasggiiESPLLPVPAFqqalarrrgrelpgrLW 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #                                                                  
gi 77416591  103 LKCDSHLPisGSIKARGGIYEVLKHAeqlalqhgmlteedd-ysildsdtcreffaTYSIAVGSTGNLGLSIGIMSAkLG 181
gi 123577205  92 LKCDNYLKvaGSIKARGGIYEVLKHAetlllenglitledd-yskiaeerfkkffsNYKVAVGSTGNLGLSIGIMAAaLG 170
gi 123624073  93 IKRDDQLPtaGSIKARGGFHEVLAIAesiaiehgmldpdgd-rrvlateaarklfsQYSVTVGSTGNLGLSIGVMAAaLG 171
gi 122423007 105 LKKDSHLPisGSIKARGGIYEVLAHAeklaleaglltledd-yskllspefkqffsQYSIAVGSTGNLGLSIGIMSArIG 183
gi 23396844  102 LKMDSHLPvaGSIKARGGVYEVLKHAeelameagllkledd-ysiladkkfkdffsKYKIQVGSTGNLGLSIGITSAaLG 180
gi 150416134  97 IKRDDLMPvsGSIKSRGGIYEVLCFAekiaiengfdlkkdn-yqdlrkdkyrklfnQWRIEVASTGNLGLSVGLMAStLG 175
gi 122265063  99 LKADNYLPisGSIKSRGGIYEVLKFAekvamkhgeivygdn-yaklneprfkdlfgQYGIVVGSTGNLGLSIGIVACkLG 177
gi 1711354   104 LKCDHELPisGSIKARGGIYEVLKYAenlalqegmlqetdd-yrilqeerftgffsRYSIAVGSTGNLGLSIGIIGAaLG 182
gi 123533127  93 LKADHDLPvaGSVKARGGIHEVLCFAeslalthgvlkdvdsdyctlasqsardlfsKHTITVGSTGNLGLSIGVIGSaLG 172
gi 115305735  98 LKADSQLPisGSIKSRGGIYEVLKFAeqvamahtdltymdd-ysvlatakyhelfaQYGVIVASTGNLALSVGIMAAtFG 176
gi 88941984  106 LKADSHLPisGSIKARGGIYEVLKHAedlalangllqpgdd-yarlaspearslfsRHGIAVGSTGNLGLSIGIMAAkLG 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 77416591  182 FNVTVHMSADakqWKKDLLRSKGVNVIEYeadyskAVEEGRRQADadpsCYFVDdensHDLFLGYAVAASRLQKQLeelk 261
gi 123577205 171 FKVDVHMSHDakeWKKKILRDRGVNVIEYredyskAVEEGRKKAAaeknTYFIDdensRDLFLGYSVAALRLKDQLtelg 250
gi 123624073 172 FDAVVHMSADakaWKKDRLRKRGVRVVEHegdyaqAVAAGREQALgatrCHFVDdersALLFFGYAAAARHLARQLaeag 251
gi 122423007 184 FKVTVHMSADaraWKKAKLRSHGVTVVEYeqdygvAVEEGRKAAQsdpnCFFIDdensRTLFLGYSVAGQRLKAQFaqqg 263
gi 23396844  181 FQVIVHMSADakkWKKDMLRSKGVQVIEYesdygkAVEEGRKNSDadpmSYFVDdeksMNLFLGYTVAASRIKKQFdkkg 260
gi 150416134 176 FKARIHMSHDatdWKINKLLQNGVEVKIYddnfsnAVAAARVSSQrdpySYFIDdegsKLLFAGYATAGERVKKQLskmq 255
gi 122265063 178 FRTSVHMSSDaaqWKKDMLREKGVNVVEYndnfthAITEARKSAEadpmAYFIDdegsYDLFLGYSVAAVRLQAQLkaqn 257
gi 1711354   183 FRVTVHMSADakqWKKDLLRQKGVTVMEYetdyseAVNEGRRQAEqdpfCYFIDdehsRQLFLGYAVAASRLKTQLdcmn 262
gi 123533127 173 FKTVVHMSSDakeWKMERLRKRGVRVVEHdadygaALEAGRLETIadpcGYFVDdersPNLFMGYAVAAKRLQAQLealn 252
gi 115305735 177 FKTTVYMSHDarqWKKDKLRANGVTVEELntdfssVIPVARAAAAkddhTHFVDdegsRDLFLGYAVAGVRLQHQLkvqg 256
gi 88941984  185 FQAAVHMSADarqWKKDKLRAHGVTVVEYqtdysaAVARGREQAArdpdCHFVDdensIHLFLGYAVAAERLKAQLaeag 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 77416591  262 ivvdeehpLFVYLPCGVGGGPGGVAFGLKLlykdNVHCFFAEPtHSPCMLIGLMTGLHDKiavqdig-idnvtdADGLAV 340
gi 123577205 251 ievnkenpLFVYLPCGVGGAPGGISFGLKTifkdDVYCYFVEPtHSPCMLLGLVTQKFSAihvrdfg-ldniteADGLAV 329
gi 123624073 252 rvvdaahpLFVYLPCGVGGAPGGITYGLKAllgdHVHCFFAEPvASPCVLVQLASGSDDPvsvydig-ldnrtdADGLAV 330
gi 122423007 264 rivnadnpLFVYLPCGVGGGPGGVAFGLKLafgdHVHCFFAEPtHSPCMLLGVHTGLHDQisvqdig-idnltaADGLAV 342
gi 23396844  261 ivinkehpLIVYIPCGVGGAPGGVAYGLKRifkeNVYIFFVEPvLAPCMLLGMQTGLHEKisvydvg-ihgithADGLAV 339
gi 150416134 256 ievskehpLVVYLPAGVGGSPSGVAFGLKLqfadAVIPIFVEPtHMPSVLLGMASGLNHDisvydig-idgktaADGLAV 334
gi 122265063 258 ikvdaehpLFVYLPAGVGGSPSGVAFGLKKiigeNVHPIFAEPtHIPSVSLGMMTGLNDQisvydag-idgvtkADGLAV 336
gi 1711354   263 ikpsletpLFVYLPCGVGGGPGGVAFGLKLlygdDVHVFFAEPtHSPCMLLGLYSGLHEKisvqdig-ldnqtaADGLAV 341
gi 123533127 253 ikvdadhpLFVYLPAGVGGAPGGITYGLKHifndHVHCFFAEPvQSPCMLLGMAGAPGAAptsiyeldlknrtdADGLAV 332
gi 115305735 257 ikmdaahpVVVYLPAGVGGSPSGVAFGLKMimgaNIYPVFCEPtHVPSVTLGMMTKLNEKiavqdig-ldgltaADGLAV 335
gi 88941984  265 vrvdadhpLFVYLPCGVGGGPGGVAFGLKQafgdAVHCLFAEPtRSPCMLLGVLTGLHDKvsvqdfg-idnrtvADGLAV 343
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 77416591  341 GRPSGFVGKTMepflsGNYTVSdEELYRLLKELADTeNIYLEPSALAGMIGPVKVCkedaylqkq--qlmekvqkgTHIV 418
gi 123577205 330 GSPSKLVAEIAnilidGIYTIEdEELFKLLALLKDSeNIKVEPSAAASLKGPLLVNsra---------------naIHIS 394
gi 123624073 331 GQASHLVSPLMasqlaGVFTVPdDQLYVQLLALKTSmGVEVEPSAAAGIGGPGWLRdspegrayvr-dhgldmrdaTHVI 409
gi 122423007 343 GRASGFVGRAMerlldGFYTLSdQTMYDMLSWLAQEeGIRLEPSALAGMAGPQRVCasvsyqqmhg-fsaeqlrnaTHLV 421
gi 23396844  340 ARPSGLVGRLMepilsGIFTVDdYKLYDYLRILNETeNKRIEPSSCAAFEGVVSLLkyedskkyienrigkninnvYHVC 419
gi 150416134 335 GRPSMIAGKYMkdklfGIATVSdSDMFAYQGMLKKLeNIEVEPSAAVGIRGLIQSKeisei-----------pdsaTHMV 403
gi 122265063 337 GRPSRIAGKMMdtllyGIQTFDdQKMMKNVAELHDSeNVDVEPSAASGFTILDDVQaqleqd--------ypmenaSHIV 408
gi 1711354   342 GRPSGFVGKLIepllsGCYTVEdNTLYTLLHMLAVSeDKYLEPSALAGMFGPVQLFsteegrrya---qkykmehaVHVV 418
gi 123533127 333 GAASQWVCDATrnllsGVYTATdEQLYQQLYLLKDLeNIEVEPSAAIGCLGPAMLTseagqkyldshrlshrmensVHIP 412
gi 115305735 336 SRPSRLAGKVMrtlllGTATFEdDDLYRYLTKLVDTeDVIVEPSAAAGFTAIAPIMaqfptl---------agkdvTHIV 406
gi 88941984  344 GRPSGFVGRAMqrlidGYYTVDdDELFRLLAMLEQTeGLRLEPSALAGAPGIARVLeenqgyrqrmgldadrlacaTHLI 423
                        410
                 ....*....|
Feature 1                  
gi 77416591  419 WGTGGSMVPE 428
gi 123577205 395 WATGGIFIPE 404
gi 123624073 410 WATGGSLVPR 419
gi 122423007 422 WATGGGMVPE 431
gi 23396844  420 WATGGKMVPQ 429
gi 150416134 404 WATGGSMVPK 413
gi 122265063 409 WATGGSMVPK 418
gi 1711354   419 WGTGGSMVPK 428
gi 123533127 413 WLTGGSFVPD 422
gi 115305735 407 WATGGDMMPE 416
gi 88941984  424 WATGGSMVPE 433

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