2RKB,1P5J


Conserved Protein Domain Family
L-Ser-dehyd

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cd06448: L-Ser-dehyd 
Click on image for an interactive view with Cn3D
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Statistics
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PSSM-Id: 107209
View PSSM: cd06448
Aligned: 15 rows
Threshold Bit Score: 395.514
Threshold Setting Gi: 171848902
Created: 10-Jul-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
catalyticpyridoxal
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:2RKB_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          #                                            
2RKB_A        7 VTPLLESWALsqva----gmpVFLKCENVQPSGSFKIRGIGHFCQEMAkkg-------crHLVCSSGgNAGIAAAYAARk 75
gi 47206245  10 ATPLRQSLPLtkea----gtsVYLKLDSSQPTGSFKIRGIGHLCKTWAerg-------ceRLVCCSGgNAGMAAAYSARq 78
gi 26989649   6 HTPLIESRPLslaa----grnIWLKLDALQPCGSFKLRGVGHACEVHHarg-------arHFVSSSGgNAGLAVAYAGRk 74
gi 28828083  28 NSPMLESLALsklfk-eenakVWMKVDALQPSGSFKIRGVGLLCNQLLkekks--kneeaHFICSSGgNAGKSVAYAGRk 104
gi 45644969   7 KTPLLRQFFPgka-----saqFFLKYECLQPSGSFKSRGIGNLIMKSAiriqkd-gkrspQVFASSGgNAGFAAATACQr 80
gi 46437720   7 TTTFVEVTDKlptk---ppcrVFFKNEYEQPSGSFKLRGMGHLVGQSIdvarkl-gksnvAVFSSSGgNAGLAAAYASQf 82
gi 46441398  19 QTSLTEVTNIlptk---ppcrIFFKNELEQPSGSFKLRGIGHLVHKSIenalknhsnktiHVFASSGgNAGLAAAYSAQf 95
gi 46125569  14 KTPCIISTQLsrlt----gcnVYLKLENLQPSGSFKTRSISSLMTQAAaaat-----gpvHFYCSSGgNAGLACATSAIs 84
gi 134388     8 KTPLIRQVFNngkt----nswFYVKHEILQPGGSFKSRGIGHLIRKSNqqplse-gsgklAVFSSSGgNAGLAAATACRs 82
gi 45199267  75 KTPLMRHVFArqnvrytanpeIMLKYEFFQPSGSFKSRGIGNLIWKEMqkirqn-sslqpHVFASSGgNAGLAAATASRq 153
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2RKB_A       76 lGIPATIVLPestslQVVQRLQGEGAEVQLTgkv-wdeANLRAQELAKrd-----gWENVPpfdhPLIWKGHASLVQELK 149
gi 47206245  79 lGVPATIVVPsvtpvMTVERLRDEGATALNE-------SIEYGKQLVAnn----pgWIFISpfddPLIWEGHTSLVKELE 147
gi 26989649  75 lGVPVTVVIPettteRAKQLLHLEDAKVVVQgss-wqeANALAQTLVGp------nDAFIHpfddPLLWAGHASLVDEVA 147
gi 28828083 105 lNVKTTIVLPntipeATIEKIKDEGANVIVHgti-wdeANTFALELAEkeg---ctDCYIHpfdhPLLWEGHSTMIDEIY 180
gi 45644969  81 lSLPCTVVVPtatkkRMVDKIRNTGAQVIVSgaywkeaDTFLKTNVMNkidsqviePIYVHpfdnPDIWEGHSSMIDEIV 160
gi 46437720  83 fGVSCTVVLPesskpTVIEKLKSLGADVIIHgkhwgeaDNYLTDFVIKnldk-tvyPVYCHpfddPLLWEGHSKIITEII 161
gi 46441398  96 yKVKCTVVLPiiskpVVQEKLKSYGARIVLFgntineaDQHLKNLMSSidld-siyPVYCHpfnnPLIWNGHSSLVDEVS 174
gi 46125569  85 lGHKATIVMPtivspLMKSKLLDLGVEVHQKgknwaecDKYMREELVAnd----psAIYVApfddPRLWDGAATMVDEIR 160
gi 134388    83 mALNCSVVVPkttkpRMVKKIQSAGAKVIIHgdhwgeaDEYLRHKLMAqesqhgskTLYVHpfdnETIWEGHSTIVDEII 162
gi 45199267 154 lGLPCTVVVPettrrRMVERIRSTGADVISMgsvlkesDDYLRSELMGnvnlekvaPIYAHpfdnPLIWEGHATMVDEVV 233
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2RKB_A      150 AVLrt------ppGALVLAVGGGGLLAGVVAGLLEvg--wqHVPIIAMEThGAHCFNAAITAGKLVTlpdi--tsvAKSL 219
gi 47206245 148 QELre------tpGAIALSVGGGGLLNGVVEGLRRag--wgDVPIVAMETlGAHSLNAAMEAGELVTlpei--tsvATTL 217
gi 26989649 148 EAGlk-------pDAVVLSVGGGGLLSGVVEGLKRng--wgDVPVLAVETeGAASLHAAMQAGHSVEleri--asvATSL 216
gi 28828083 181 QDVqngv--cekpDVILFSVGGGGMMIGILQGLDRyg--wnDIPIVTVETvGSHSFWKSFQEKQLTKldvsevtsvIKTL 256
gi 45644969 161 QDLksqhisvnkvKGIVCSVGGGGLYNGIIQGLERygl-adRIPIVGVETnGCHVFNTSLKIGQPVQfkki--tsiATSL 237
gi 46437720 162 DQKqlpn--fdkvKGVICSVGGGGLYNGIVEGLENh----kEIPVLAIETkQAATFHEAVKEGKVVHlqkv--qtlATSL 233
gi 46441398 175 QQLdskd--rkllKGMVCSFGGGGLYNGIYQGMVKnq---iRGDILLIETlQAPTLTQSLEADEVITlksv--nslATSL 247
gi 46125569 161 DQLed------rvDGIVCSVGGGSLVNGLMQGIESrpwlgtKPAVLAVETeGADSLNASVLAGEHVTlpem--tsiATSL 232
gi 134388   163 EQLkendislprvKALVCSVGGGGLFSGIIKGLDRnhl-aeKIPVVAVETaGCDVLNKSLKKGSPVTlekl--tsvATSL 239
gi 45199267 234 EALhlqgvqlesvKGIVCSVGGGGLYNGIVYGLEKhgl-adSIPVVAVETeGCEVLHRSLLLGRNVSmnp---ksvATSL 309
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
2RKB_A      220 GAKTVAARALECMqvc---kiHSEVVEDTEAVSAVQQLLDDeRMLVEPACGAALAAIYSGLlrrlqaeg--clppsltSV 294
gi 47206245 218 GLARVSAQTLKLVkeh---avFSEVVTDQEAVKAVERFVDDeKILVEPACGAALAAVYSGVlkklqceg-klakqmggPV 293
gi 26989649 217 GAKRVADQALMCVqqh---pvHSHLVSDRAALEACERFLLDhRVLVEPACGAALAVAYDAKalg-----------alrNV 282
gi 28828083 257 STRSVCSEAWEISkrf---niKPILVTDRDAVDACLKFVDDeRILVEPSCGATLSVLYSKKlstll-------dinskNI 326
gi 45644969 238 GTAVISNQTFEYArky---ntRSVVIEDKDVIETCLKYTHQfNMVIEPACGAALHLGYNTKilenalg---sklaaddIV 311
gi 46437720 234 ASPYLSSKALANYier---ptVLAEIDDLDAVKGVVDVYDHfGYMVEPACGASVASVMHRQdllnkfg----tlspddII 306
gi 46441398 248 ACSYTTEQSLKYYkdqslvksQVELIDDIDSLRACVAFEKCfGKVVEPACGAAMAVVYNKIdllyknf---khlqpedIV 324
gi 46125569 233 GATRVSEQTWKWSqhps-gmmKSLVVSDADAAISTVRFADDaLQLVEVACGAALAIAYRGDlrdvlgkglsdeewsktNV 311
gi 134388   240 ASPYIASFAFESFnky---gcKSVVLSDQDVLATCLRYADDyNFIVEPACGASLHLCYHPEiledile---qkiyeddIV 313
gi 45199267 310 CTSFVTDLTLSYAqky---rtKSVVLDQLAVVQTCLNFAEEsNIVTEPACGAALHLGYHPEilerelg----pltpqdVV 382
                       330       340
                ....*....|....*....|..
Feature 1                             
2RKB_A      295 VVIVCGGNNInSRELQALKTHL 316
gi 47206245 294 VIVVCGGNNIsFGQLQKLKKQL 315
gi 26989649 283 LVVVCGGATAtLEQIQAWLQQA 304
gi 28828083 327 LTIVCGGNGTsILQLNDLLQTL 348
gi 45644969 312 IIIACGGSSNtIKDLEEALDSM 333
gi 46437720 307 IVVICGGSAInKYIIDEYRSLL 328
gi 46441398 325 VIVVCGGSCTtGSDLKGFEKMI 346
gi 46125569 312 VFVVCGGSGItLSMLSEYREKY 333
gi 134388   314 IIIACGGSCMtYEDLVKASSTL 335
gi 45199267 383 IVIACGGSTMnLADLKESEDQL 404

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