Conserved Protein Domain Family
SufS_like

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cd06453: SufS_like 
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Statistics
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PSSM-Id: 99746
View PSSM: cd06453
Aligned: 103 rows
Threshold Bit Score: 396.836
Threshold Setting Gi: 83816050
Created: 27-Jun-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
catalyticpyridoxal
Feature 1:catalytic residue [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 159184934  27 TYLDNGASAQKPQVVIDAVshay-sneyANVHRGLHFlsnaaTDAYEAAREKVRRFLNagsvDEIVFTKSSTEAINTVAY 105
gi 77919327    3 IYLDNAATSFPKPASVYQAvddalrhrgGSPGRGSHHmaleaGRLLMACRDTAAGFFGirdtSRVVFTGNATEALNLALF 82
gi 110600953   3 VYLDNAATTFPKPDPVYGAvehalreigVGPGRGGYKrslaaSRLVFEAREILASFFGitdsSRLVFTHSATEGLNIAVN 82
gi 118580908   9 IYLDNAATSHPKPECVYQAvvhamrhigASPGRAGHRrsleaSRLLFQVREAIATLLSvpdsSRIIFTHSATEALNLALQ 88
gi 145619856   3 VFLDNAATSFPKPETVYLAmdaalrevgVAPGRGGYRqslaaARIVYEARSALARFFGvsdsSRLIFTHSATESINIAVN 82
gi 87312364    9 IYLDNAATSWPKPPGVIEAmrrhleqigAPAGRSGYHeaavvERAVSETRRQLAYLLGvreaERVVFTFNGTDSLNTVMH 88
gi 150389784   3 VYLDNAATSYPKPREVLDAvydfmlnngATSGRGAYErammaDGLVYDTRKMIANLFNfhdpKKVIFTANITESLNLAIK 82
gi 150389618   3 VYLDNAATSYPKPKEVVDAvydfmlnngATSGRGAYErammaDGLVYDTRKMIANLFNfhdpKKVIFTANITESLNLAIR 82
gi 116748645   3 LYLDNAATSFPKPPSVYEAvrhaltevgASPGRASHRharlaSSMVGAAREKVASFLGigdaDRVIFTKNATESINIVLK 82
gi 124005759  17 THLNNAGAALIPQAVIDVQrdy----mnQEANYGGYEtaakfADELQTTYTRVARLINaq-pSEIALVESATVAWGKAFF 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 159184934 106 GYGmpvigeGDEIVISIMEHHSNIVPWHfirerqGAKLVWVPvDDDGAFHIEAFEKSlte------rtKLVAITHMSNAl 179
gi 77919327   83 GLLn----pGDRVVTSTMEHNAVLCPLQalq-trGLKVVKVPpGADGRLHPDSVREAvmvd---akatRLVVLTHASNVt 154
gi 110600953  83 GLLk----pGDHVVTTTMEHNSLVRPLYaak-nrGVQITWVSaDRNGSIDPAAISAAlrp------etKLIALSHCSNVt 151
gi 118580908  89 GVLl----aGDHVVTTSMEHNSLLRPLYqlr-rrGVELTIVEaAGDGLVDPDAVRRAfrp------ttRMLALGHVSNVc 157
gi 145619856  83 GLLk----pGDHVVSTRVEHNALLRPLHlaa-srGVEVTYVPsDRFGVVSEREIERAmrp------gtRLVALAHCSNVt 151
gi 87312364   89 GFLr----aGDHVVTTTIEHNSVLRPLAylasrrGIEVRHAApDAQGVVSPQAIEEAlne------ksRLIVISHASNVt 158
gi 150389784  83 GIVk----kGDHVITSSLEHNAVWRCLKtlerdrGISLSVVPaAKEGYINPLDVKDLirk------ntTLIVLNHASNVf 152
gi 150389618  83 GIVk----eGDHVITSSIEHNAVWRCLKtlerdrGISLSVVPaSKEGYTNPLDVKDLiqk------ntVLIVINHASNVf 152
gi 116748645  83 GWLk----rGDRVLISAMEHNSVVRPLKrls-eiGVSTEIVPcSGSGAIDVDELRRRles------rpRLMAMTHASNVn 151
gi 124005759  92 ALDlq---pGDRVATAMAEYASNYINYLqaqkthGIKIEVVPnDKHGQLSLEALEQLlaedkasegkiKLISITHVPTNg 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                        #                               
gi 159184934 180 GTILPVKEICRIAHERgIPVLVDGSQGavHMPVDVrdidCDWYVMTGHKLYGp-sGIGVLYGKTERLREMRPfqgggemi 258
gi 77919327  155 GAIQPIEEIGPWCRSLgIPLLVDAAQTagYIPVDVedmgIDLLAVPGHKHLMgppGCGFLYVREGLQLTPLLyggsgsds 234
gi 110600953 152 GTIQPIASIGDTARKAgVFFLVDAAQSagCMPINImdqkIDLLAVPGHKGLLgpqGTGLLYIAEHVDLSPFLlggtgtss 231
gi 118580908 158 GAIQPVARLATIAREAgALFLLDAAQSagSIPIDAaglgVDLLAAPGHKGLLgpqGTGFLFVAEGVEIRPLLaggtgsns 237
gi 145619856 152 GAVQPIEAIARVARQNgAVFLVDAAQSagFFPIEAertgIDLLAAPGHKGLYgppGTGVLTIAEGLNLEPLLvggtggsa 231
gi 87312364  159 GALQPIEAITEMAHRRgVRVLVDGAQTagHTPIRLeesgVDFFACSGHKGLLgplGVGVLYLAPGAEIETESfrqggtgt 238
gi 150389784 153 GTIQPIGEIGAIARENsIPLLVDAAQTagVLPIDIkednIDLLAFTGHKSLLgpmGTGGLIVNWDGEIDPLKsggtggds 232
gi 150389618 153 GTIQSIGEIGAIAREHsIPFLVDAAQTagVLPIDIkkdnVDLLAFTGHKSLLgpmGTGGLVVNWDGEMDPLKvggtggds 232
gi 116748645 152 GALLPAEAVAQMCSEFgVPLLLDAAQTagVQAIRAdkwrLAMLACSAHKGLLgppGVGVLFIRSGLDVEPLLeggtgsrs 231
gi 124005759 169 GLVNPAEEVGKLAKKYgVLYLLDACQSvgQLPVDVqqigCDMLSATGRKYLRaprGTGFLYVSERILQDLEPkvldltsa 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 159184934 259 ldvsednvtynepphRFEAGTppiVQAIGLGYALDYMdnlgr-aaiaaHEADLAAYAATRLRevnslrii--gnapdkgg 335
gi 77919327  235 gs----plppehmpeRLESGTanlPALAGLKAGIDFLektgf-vnlrrHKKELMAHLADGLSalpgirrygptdisllag 309
gi 110600953 232 sd----taqpetmpeKFESGTlntPGIAGLKAGVEFIlktgi-dnirqKEIKLVSLLLDGLKqlprvktftaynaesrgg 306
gi 118580908 238 ss----eeqphilpeGFEAGThnlPGIAGLLAGVEFVlargvdvigrrEREHVAEVARRLAPlpgmaihgp-sfpanrsg 312
gi 145619856 232 ss----peqpdqlpeRLESGTintPAIAGLKAGVEFVlttgi-dviraKEELLVNQLLEGLRatphvevyg-plegarga 305
gi 87312364  239 lsq--hpqqpdtlpdKYESGNpnvTAILGLQAAVEYLrdrtv-taierEMRERTAQLLEGLAgipsidvfgplsaadrig 315
gi 150389784 233 ay----eyqpdyfpnRLETGTlnvSGIVGLRAALKFIqnegi-ekifeKEKHLVGYALDRLEevrgisiygpkdpnkivg 307
gi 150389618 233 ay----eyqpdyfpnKLETGTlnvSGIVGLRSALKFIqkegi-eriyeKEKDLVGYALNRLEeirgisiygpkdpnkivg 307
gi 116748645 232 ed----aiqpeicpdRYESGTpnlPGIAGLAAGIDYIlssgl-etirdHELGLAVRLEEQLRaipgitvi--spevrgta 304
gi 124005759 249 kwtaksayemrtdgvRFENYEynrANRLGLSEAVQYAldlgm-eniwqRIQQLGNLLRQRLVelpnvqvy--dlglvkgg 325
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                                                                             
gi 159184934 336 IFSFELegiHAHDVSMVIDr-rGVAVRAGTHCAMPLLk---rFGVTSTCRASFGLYNtRAEVDRLVEAL 400
gi 77919327  310 ALSFNLsglDPAEIAFWLDnehAICVRAGLHCAPDTHrs-lnTFPRGTVRVSPGYFSrHEDIQALIHAL 377
gi 110600953 307 AVSFTVegiDPATIGFHLDadfDISVRVGLHCAPMAHkt-igTYPHGTVRVSPGFFNtDKDIAFLLDAL 374
gi 118580908 313 LLSFTLagmDASSLAFMLDqrfDIAVRAGLHCAPLAHrs-lgTYPAGTVRVSPGWFTsNDEIAIFCDAV 380
gi 145619856 306 AVSFNAaghDPAALSFLLDsdyDISVRAGLHCAPDTHrs-igTYPTGTVRVSPGFFNtEADIDFFLKAL 373
gi 87312364  316 VVSLNVpgfDPHELASYLDsahHIQVRAGLHCAPLMHqqlgtTDRGGAVRFSVGAFTtAAEIEKVLSAL 384
gi 150389784 308 VISFNLqevSGEEVAYILDqeyGVMVRVGLHCAPGPHkm-igKEKEGTVRIGIGYFNtEEDIDLLVNAL 375
gi 150389618 308 VISFNLqgiTGEEVAYTLDqeyGIMVRVGLHCAPGPHri-idKVKEGTVRIGIGYFNeKEDIDLLVNAL 375
gi 116748645 305 TVSFTMagiNPADAGHLLDegyDIAVRTGLHCAPLAHrt-fgTFPEGTVRVSPGYATtAADMERLAEAI 372
gi 124005759 326 IVSWGIegiPAEFVVEKLRe-vQINTSLILESGTLLDmq--eRELPPLVRSSVHYYNtEEEIEKLCGEL 391

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