Conserved Protein Domain Family
p23_hB-ind1_like

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cd06465: p23_hB-ind1_like 
Click on image for an interactive view with Cn3D
p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) kappaB and activation of c-Jun N-terminal kinase (JNK). hB-ind1 also plays a part in the RNA replication and particle production of Hepatitis C virus (HCV) through its interaction with heat shock protein Hsp90, HCV nonstructural protein 5A (NS5A), and the immunophilin FKBP8. hB-ind1 is upregulated in the outer layer of Chinese hamster V79 cells grown as multicell spheroids, versus in the same cells grown as monolayers. This group includes the Saccharomyces cerevisiae Sba1, a co-chaperone of the Hsp90. Sba1 has been shown to be is required for telomere length maintenance, and may modulate telomerase DNA-binding activity.
Statistics
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PSSM-Id: 107222
View PSSM: cd06465
Aligned: 56 rows
Threshold Bit Score: 93.8132
Threshold Setting Gi: 66828311
Created: 2-Jul-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Hsp90 binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:Hsp90 binding site
Evidence:
  • Structure:2CG9; Saccharomyces cerevisiae, showing two symmetrically disposed Sba1molecules complexed with a yeast Hsp90 (Hsp82) homodimer, contacts at 3.5A.
    View structure with Cn3D
  • Comment:in this Hsp90-nucleotide-p23 (Sba1) closed chaperone complex each Sba1 molecule contacts both monomers of the Hsp90 (Hsp82) dimer.
  • Comment:this is a lower resolution structure (Resolution 3.10 A, R-Value of 0.314, R-Free of 0.353, and the overall B factors average 70 or above). A caution that the co-ordinates of the first block may not be correctly assigned as this sequence-conserved region is assigned a different position structurally in the other alpha-crystallin-type Hsps and p23-like structures.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #                  ##                                                #    
2CG9_Y         7 PQVAWAQRssttdpernYVLITVSIADcdAPELTIKpsYIELKAQskphvgdenvHHYQLHIDLYKEIIPekTMHKVAng 86
gi 6735452     8 PHVYWAQRh-------rELYLRVELSDvqNPAISITenVLHFKAQghga---kgdNVYEFHLEFLDLVKPe-PVYKLTq- 75
gi 156358405   7 PIVRWAQTk-------eRLYLTLELSDvqYPSIDLTesRLLFKGYghga---kgeDNYELEVNFLEPINPgeSSHKVMe- 75
gi 145536355   7 PIVKWAQRk-------dNIFLTVEVRDlkDEKVELTstSLKFSANae-------gVNYAFEINFYAEVIVeeSKWTNYg- 71
gi 169154538   6 PHVYWAQRh-------gEIYLRVEISDaqDLSIGVEenILQFRGQghga---kgeNEYEFSLEFLKPVKPe-VKHKSTq- 73
gi 110555146   9 PQCAWAETk-------eFIFLTVQVQSpeDLQVNLQesSLDFKCTsd-------kKAFAFHLDFPHPIIVedSKYSVQ-- 72
gi 115946758   9 PLVYWAQTe-------kTISLKVDLNDvsSPEVELKskTLTFKGYglga---sgiHQYEFSLDFHDEVDPdaSAFRVLd- 77
gi 56119080    8 PHVHWAQRh-------rELYLRVELSDvkNPDVSIAdnVLRFRAQghga---kgdNIYEFQIEFLEPVEPk-PVCRVTq- 75
gi 156088383   5 PNVLWAQTd-------dALLLTVELPEekDTVINLDnnALKIAGKke-------gKDYECTINFYKPIKA--SEALKAn- 67
gi 146165257   6 TPFSWAQRr-------dRIFISINLRDitEEKIDLQptSLSFDCTsd-------kKQYHGVVNFYDEIDVesSKKTILg- 70
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
Feature 1          #               #           # ## ## #     
2CG9_Y        87 qHYFLKLYKKdle-seYWPRLTkekVKYP-YIKTDFDKWVDADE 128
gi 6735452    76 -RQVNITVQKkv--sqWWERLTk-qEKRPlFLAPDFDRWLDESD 115
gi 156358405  76 -RYVEFSIAKqkgrefFWQRLVd-sEKRPnWLKINFDRWKNEDD 117
gi 145536355  72 -VNVRFILSKkdqaasYWTRLIkeaHKLQ-YLQVDWTKYIDEDD 113
gi 169154538  74 -RQVNITVRKqe--evWWNRLTk-qEKKPlFLAPDFDRWLDESD 113
gi 110555146  73 -RNVQFKLVKke--keRWRTLSg-kTKLH-WLKCDWDKWIDSDD 111
gi 115946758  78 -RQVDFNISKksv-lsFWPRLTs--GERPrWLRIDFDRWRSGES 117
gi 56119080   76 -RQLNITVQKke--ssWWERLTk-qEKRPlFLAPDFDRWLDESD 115
gi 156088383  68 dRFLRFKLPKde--neKWPSLNn-dGKKH-WIKIDWNRWIDSDA 107
gi 146165257  71 -FGARIVLFKknteapYWPRLTkegGKHN-NITFDWERYIDSDE 112

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