Conserved Protein Domain Family
p23_CS_SGT1_like

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cd06466: p23_CS_SGT1_like 
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p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. ScSgt1 is needed for the G1/S and G2/M cell-cycle transitions, and for assembly of the core kinetochore complex (CBF3) via activation of Ctf13, the F-box protein. Binding of Hsp82 (a yeast Hsp90 homologue) to ScSgt1, promotes the binding of Sgt1 to Skp1 and of Skp1 to Ctf13. Some proteins in this group have an SGT1-specific (SGS) domain at the extreme C-terminus. The ScSgt1-SGS domain binds adenylate cyclase. The hSgt1-SGS domain interacts with some S100 family proteins, and studies suggest that the interaction of hSgt1 with Hsp90 and Hsp70 may be regulated by S100A6 in a Ca2+ dependent fashion. This group also includes the p23_like domains of Melusin and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). Melusin is a vertebrate protein which interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.
Statistics
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PSSM-Id: 107223
View PSSM: cd06466
Aligned: 91 rows
Threshold Bit Score: 60.2931
Threshold Setting Gi: 123892457
Created: 29-Jun-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1RL1_A        13 DWYQTesQVVITLMIKNvq-knDVNVEFSe--kELSALVKlp-sgEDYNLKLELLHPIIPe--qSTFKVLsTKIEIKLKK 86
gi 6581052   224 DWFSSngFVTINVYCRGal-peTANIVSDg--hTVRVSMKhgfgnASVDLDYDLWDEVIPe--eSRVVIGeRKVEISLKQ 298
gi 123892457 173 DWFQTesLVTVAVYTKMkn-vcSELVIVDhlenVLRGEIIig--dYSYLLHSELSHPVQKdi-eVKVSATaGKIEIKMKK 248
gi 156324919  72 DWYQNdrIVTIAVYTRAkdiqmDSIILELkdqkDLNAIFIlg--eKSYQLHLDLEEKVSNq--qVRIANDtGKVDLLLTK 147
gi 66472432  179 DWFQTdgTVNIVVYTKRki-psAGCAVVDlqddNLRVEMLlg--rMSYLLYWRLSSRVQDhv-dVQTAHSvGKVQLCLRK 254
gi 190584960 209 DWYQSdkSITIVVYTKHkgltnEDILVNVknnrKTDIWIVlg--dKILQLCLDLFEEICEs--eVKISTE-GNIEVILLK 283
gi 125807293 192 DWIQQrsELTLFFYTRSfs-npGLIVRRKdp-qQLVARVFle--sRWHTFDLQLAGKVEWppkaVRVGTEtGKIELVLAK 267
gi 66771089  191 DWIQQrsELTLIFYTRSla-npGLVVRRKdl-qQLSVRVLvq--hNWHSFDFQLTNNVEWppklAKIGSEtGKIELVFVK 266
gi 170066947 157 DWIQKtaEVSFIFYTRAlc-npAVIVELVnn-lEFNVRFFle-gnVLHRYRFQASNNLQWpc-tVRQSLEtGKVEIVFNK 232
gi 158287260 150 DWIQKtaELTLIFYTRSla-npGVMVECVdh-lEVTVNILle-ssVQHRYRFHLANNVRWpc-tVRTSLEsGKIELMFNK 225
                         90
                 ....*....|..
1RL1_A        87 pea--vrWEKLE 96
gi 6581052   299 khg--tgWPRLK 308
gi 123892457 249 kep--vsWKSLG 258
gi 156324919 148 depesqfWECTL 159
gi 66472432  255 svk--ekWTQLG 264
gi 190584960 284 qei-gkkWLSLG 294
gi 125807293 268 eep--apWSSYG 277
gi 66771089  267 eea--epWPTYG 276
gi 170066947 233 llp--glWTNYG 242
gi 158287260 226 lcp--alWTSYG 235
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