Conserved Protein Domain Family
p23_NUDC_like

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cd06467: p23_NUDC_like 
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p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart.
Statistics
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PSSM-Id: 107224
View PSSM: cd06467
Aligned: 123 rows
Threshold Bit Score: 59.8686
Threshold Setting Gi: 115483646
Created: 19-Mar-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WFI_A         10 YRWTQTl--aELDLAVPFRVsfrlkgkDVVVDIQrrHLRVGLKg---QPPVVDGE-LYNEVKVe--eSSWLIEd------ 75
gi 91079410   267 YKWSQTs--eDLTIKFPLPEnfk--knLVHVTTEptHISLKYE----NETLLTGK-LYHQIDPd--vTCWTIEs------ 329
gi 125981501  296 YTWTQTd--eDVLIRFRLPAgat--rnDFNIRSTshQLEVECL----AEILLTGA-LYANVDSd--lTTWTIEa------ 358
gi 66475884    92 YYWTQTe--nDLTIVIEISPemq--skDFKINVTenSITIMYG----LETILFEK-FEYEVKYddntIFWSIKdvesfdk 162
gi 190622973  298 FSWTQTd--dELSIKFPLDGvvr--rpDFQIRST--ATTVQVEh--lGRVLIAGT-LFGHVDNe--lTTWSFGi------ 360
gi 157133714  277 FSWTQTm--eNITITVPKVEg-----lDYKITNE--HLKLSVSs--gATSIINSEgWFAGVDGe--lTSWINEs------ 337
gi 18403860    80 YEFTDGg--kEVELRLRLKTgeilspkDISVDADgtSLAVKEKrnglLITLLETNhLFEKIMPs--eTIWYIDe------ 149
gi 115483646   70 YEFTDGg--gEVELRLDIGKlgiensrDVFVDVDdtSLLVRAKsdgtLRTLINVKqLFDRIKSs--eTIWFIDe------ 139
gi 156543830  264 YCWSQDe--dSITVYTKISEkys--kvTAKVEATptSLTISVG----DVVLLSGE-TPHRLESd--lTTWKRKe------ 326
gi 110758748 2093 YVYIENsdedSITVWLKIDNqy---rdKIKVNVTslELSVTVN----NNVLIEGQ-CQYRLDEd--lTTWKYEq------ 2156
                          90       100       110
                  ....*....|....*....|....*....|..
1WFI_A         76 -------gKVVTVHLEKink----mewWNRLV 96
gi 91079410   330 --------STLVLTLQKces----glmWPEIV 349
gi 125981501  359 --------DSLQLTLVKqlq-----qsWPLLL 377
gi 66475884   163 vqnkriinKMLVLELEKkelntsirlwWKRIF 194
gi 190622973  361 --------SKLQLTLIKaep-----lrWPRLF 379
gi 157133714  338 --------EEIQITLFKtip-----glWPFLY 356
gi 18403860   150 --------DQLVVNMKKvdg----elkWPDIV 169
gi 115483646  140 --------DQLVVNLKKveq----elkWPDID 159
gi 156543830  327 --------DTLEVELSKsen----glmWSELL 346
gi 110758748 2157 --------DTFKLELYKhen----glmWNELI 2176
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