Conserved Protein Domain Family
p23_CacyBP

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cd06468: p23_CacyBP 
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p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development.
Statistics
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PSSM-Id: 107225
View PSSM: cd06468
Aligned: 27 rows
Threshold Bit Score: 83.0815
Threshold Setting Gi: 71411176
Created: 19-Mar-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1X5M_A        20 ISNYGWDQSdkFVKIYITLTGVhqv--pteNVQVHFTerSFDLLVKnl-------nGKSYSMIVNnLLKPISVegSSKKV 90
gi 145481839  91 FAFYDADEMnvRVVVELKDIAKhp----leKFQARFFekSFEIKIHdy-------qNKNWTFGVArTQCKLDAanSKFTL 159
gi 118361264 111 FSFFESGDWsvKVNIDLPGIQNhd----isKIQCRFLetSFELKIHef-------kGKNYLFSVPrASNKIDFnkSKIQI 179
gi 18397342   76 LGTFSWDQDndKVKMYISLEGVde-----dKVQAEFKpmSLDIKIHdv-------qGKNYRCAIPkLCKEIMPekCKVLV 143
gi 145526775  71 ITKYAWDQEgnKIKIIISLDGIgql--pkeNIISSFSthSVDVKILny-------kGINQRFGIKkTFDDLKDreCSIKT 141
gi 116779010  68 LGSFSWDQDneKIKVYLFLEGVnq-----eKVISDFQpwSFDVKLHdi-------qGKNYRCGVPkLNKAIVPekCRLTV 135
gi 118364389  79 LTKYAWDQNgqNVNVSLYIDDIskv--npsNVQVTFTdqSFEVKVLdl-------nGRNYKFAIPkLYDKIKPseCKYVI 149
gi 168049749  77 LSTFSWDEEseKVKIYISLEGAaq-----eKVEADYQeqSVNLKIHdv-------nGKNYQFAVPrLAKKIVPsaCKFLV 144
gi 145550337  70 ITKYAFDQEesKITIIINMEGIgel--pkqNIQVEFGknCFDVRVIgy-------rNANHRLQIKkTFGDFLHkmSSFKV 140
gi 71411176   77 VTKYSWCDAenAVTVYVDTKVEgqesladgTLQVEFKkrTLSLSYVanvvsskatpLQRKKQLLLhLSKSINVdkSEYKV 156
                         90       100
                 ....*....|....*....|....
1X5M_A        91 Kt--DTVLILCRKkventrWDYLT 112
gi 145481839 160 Kg--DKILITLRKvkkednWFSIH 181
gi 118361264 180 Ke--NQVTIVIRKnskddhWLSLH 201
gi 18397342  144 Kp--KRIVITMVKssr-gnWLDIH 164
gi 145526775 142 Tn--NSLIVNLIKken-khWDQLA 162
gi 116779010 136 Kp--QRVIITLQKaek-gnWQDIY 156
gi 118364389 150 Ks--SSISIKMKAtk--syWSQLT 169
gi 168049749 145 Kp--KRVILTLKKadl-gsWFELT 165
gi 145550337 141 Tk--NNIHVILILpdk-tqWTQIK 161
gi 71411176  157 KepsGQVVLRLVKekpskwWELVK 180
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