Conserved Protein Domain Family
p23_DYX1C1_like

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cd06469: p23_DYX1C1_like 
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.
Statistics
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PSSM-Id: 107226
View PSSM: cd06469
Aligned: 16 rows
Threshold Bit Score: 90.7936
Threshold Setting Gi: 118348986
Created: 20-Mar-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233782  10 WEQSenDVYISVPLKGtkasASNVLCSESYLKVNf--PPFLFEAFLFAPIDDs---tSSAKIGn----GVILFNLHKKep 80
gi 167521033  10 WTQTddEVHLEVPLKGvhpkKADVYTNDVFVKVNa--PPFLFEVDLFAAIDDg---aSKAVIGn----GVAVFTLVKRep 80
gi 91092102   10 WSQTdnTVTIKVPLRGihhsKVDIFYSKLYIKASf--EQYFFEVFLYKQIDPk---tSSCTFTs----THILFELIKCea 80
gi 159486715   9 WTETdvAIEVTVEVPGvsksKADVFATDAFLKVNs--PPYLFALDLAKDVDDt---rSSATILp----GKVVFTLFKRep 79
gi 72015966   10 WEESdtDVHITVPIKGnnssKADLFSSDEYIKVNs--PPYFFEMFLYAGVDDs---kSVAQLGd----GVIVFKLIKKel 80
gi 167872833  10 WSQEadQVTIRVQFPEnylrPEEVFTSEQFLKINk--PPYYWEALLANPILDr---eSRCAILe----NEVVFNLRKKep 80
gi 74026192   30 WEQTntEVLLRITIKGfkkeAIDIFVSDLLVKVNa-sPTYLLVLDLLHPIDEa---kSTHFMDpe-drTCLRVRLRKRvp 104
gi 118348986  28 WYQDnkIVKIRIPIKGitmkKIDIFISDLVLKINiteKKWVRVLDLKHEIDFqgqenNVVYAN-----EVLEIILVKKee 102
gi 146096912   9 WEQTgeDVLLHITIKGckkdAVDVLIADVFVKVNa-pPQYLLALDLLHAIDSs---kSSQYFTdaqdgIILHVKLHKAev 84
gi 68697271   21 SSQSvvSIVLRVPFPAnrfqPDDIFTMEQFLKISh--PPHYWELFLAHPIDAd---aSHCSILe----NEVVFELVKQdp 91

                 ....*...
gi 148233782  81 -avWDALT 87
gi 167521033  81 -atWPTLH 87
gi 91092102   81 -ttWENLE 87
gi 159486715  80 -gvWGVLA 86
gi 72015966   81 -giWGQLS 87
gi 167872833  81 gleWTLLE 88
gi 74026192  105 -elWESLC 111
gi 118348986 103 kkhWEDLI 110
gi 146096912  85 grvWDALS 92
gi 68697271   92 tvcWDTVE 99
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