Conserved Protein Domain Family
ACD_HspB7_like

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cd06479: ACD_HspB7_like 
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB7, also known as cardiovascular small heat shock protein (cvHsp), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. HspB7 is a 25-kDa protein, preferentially expressed in heart and skeletal muscle. It binds the cytoskeleton protein alpha-filamin (also known as actin-binding protein 280). The expression of HspB7 is increased during rat muscle aging. Its expression is also modulated in obesity implicating this protein in this and related metabolic disorders. As the human gene encoding HspB7 is mapped to chromosome 1p36.23-p34.3 it is a positional candidate for several dystrophies and myopathies.
Statistics
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PSSM-Id: 107234
View PSSM: cd06479
Aligned: 5 rows
Threshold Bit Score: 135.432
Threshold Setting Gi: 149383936
Created: 28-Apr-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #####      # # ##                                 #                    ##      
gi 12643877   73 GNIKTLgdAYEFAVDVRDFSPEDIIVTTSNnHIEVRAEKLAADGTVMNTFAHKCQLPEDVDPtsVTSALRedGSLTIRAR 152
gi 54400582   64 GNIKTLgdTYQFTVDVQDFSPEDVIVTTSNnQIEVHAEKLASDGTVMNTFTHKCRLPEDVDPtsVKSSLGadGTLTIKAQ 143
gi 148236309  63 DNVKSVgtTFQFAVDVRDFSPEDIIVTTSNnQIEVHAEKLGADGTIMNTFTHKCQLPEDVDPttVTSALGedGNLTVKAQ 142
gi 118101135  51 GNVKTLgnTYQFTVDVSDFAPEDIIVTTSNnQIEVHAEKLAGDGTVMNTFTHKCQLPEDVDPtsVSSSLGdnGTLTIRAI 130
gi 149383936  99 GVVRAVgeNYFLSADVSGFEPHEVVVLAYNqCVVIHAEKSGSDVGVSGRFTHKSVLPADMDPlsVSSSLTsdQTLIVSIR 178

                 .
Feature 1         
gi 12643877  153 R 153
gi 54400582  144 R 144
gi 148236309 143 R 143
gi 118101135 131 R 131
gi 149383936 179 R 179

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