Conserved Protein Domain Family
ACD_HspB8_like

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cd06480: ACD_HspB8_like 
Alpha-crystallin domain (ACD) found in mammalian 21.6 KDa small heat shock protein (sHsp) HspB8, also denoted as Hsp22 in humans, and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. A chaperone complex formed of HspB8 and Bag3 stimulates degradation of protein complexes by macroautophagy. HspB8 also forms complexes with Hsp27 (HspB1), MKBP (HspB2), HspB3, alphaB-crystallin (HspB5), Hsp20 (HspB6), and cvHsp (HspB7). These latter interactions may depend on phosphorylation of the respective partner sHsp. HspB8 may participate in the regulation of cell proliferation, cardiac hypertrophy, apoptosis, and carcinogenesis. Point mutations in HspB8 have been correlated with the development of several congenital neurological diseases, including Charcot Marie tooth disease and distal motor neuropathy type II.
Statistics
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PSSM-Id: 107235
View PSSM: cd06480
Aligned: 4 rows
Threshold Bit Score: 170.515
Threshold Setting Gi: 183986593
Created: 29-May-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #####             # # ##                                    #                  
gi 7657146    80 GVPAEGrtpppfPGEPWKVCVNVHSFKPEELMVKTKdgYVEVSGKheekqqeggivsKNFTKKIQLPAEVDPvtVFASLS 159
gi 183986593  88 ESPRRAsapptdSDEPWKVCVNVHSFKPEELNVKTKdgFVEVSGKheekqdeggivtKNFTKKIQIPLDVDPvtVFASLS 167
gi 50756697   81 GGYPESrspaptSREPWKVCVNVHSFKPEELTVKTKdgYVEVSGKheeqqveggivsKNFTKKIQLPYEVDPitVFASLS 160
gi 148232008  87 TGNPEPrntvanVSQPWKVCVNVQTFMPEELTVKTKdgFVEVSGNheeqqkeggivsKNFTKKIQLPPEVDAltVFASLS 166
                         90
                 ....*....|.
Feature 1          ##       
gi 7657146   160 peGLLIIEAPQ 170
gi 183986593 168 peGVLIIEARQ 178
gi 50756697  161 peGLLIIEAPQ 171
gi 148232008 167 peGLLIIEAPL 177

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