Conserved Protein Domain Family
ACD_HspB9_like

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cd06481: ACD_HspB9_like 
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB9 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Human (h) HspB9 is expressed exclusively in the normal testis and in various tumor samples and is a cancer/testis antigen. hHspB9 interacts with TCTEL1 (T-complex testis expressed protein -1), a subunit of dynein. hHspB9 and TCTEL1 are co-expressed in similar cells within the testis and in tumor cells. Included in this group is Xenopus Hsp30, a developmentally-regulated heat-inducible molecular chaperone.
Statistics
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PSSM-Id: 107236
View PSSM: cd06481
Aligned: 7 rows
Threshold Bit Score: 100.17
Threshold Setting Gi: 167963464
Created: 27-Jun-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #####       # # ##                                         #                    
gi 46576635   45 EDNDHardGFQMKLDAHGFAPEELVVQVDg-qWLMVTGQQqldvrdp-ervsyrmSQKVHRKMLPSNLSPTAMTCCLTps 122
gi 232279     86 SGKDGk-dHFELTLNVRDFSPHELTVKTQg-rRVIVTGKHerksdtedgnyfheyREWKREAELPESVNPEQVVCSLSkn 163
gi 46576643   50 NGCEQp--SFQIKVDAQGFAPEDLVVRIDg-qNLTVTGQRqhesndpsrgryrmeQSVHRQMQLPPTLDPAAMTCSLTps 126
gi 1835585    79 LDKEGe--HFGLMLDTQGFSPEDLSVRQVg-rKLRVSGKTekkqedgkgsysyslQEFRQEFDLPEGVNHEDVRCHLSpd 155
gi 58037558   71 APAQGsgeGFSVCQDVKNFAPEQLSVKVVg-rKVVLVGQKetqntdekgsfsykyEVLKREWDVPEEVDAEALTCSPVpg 149
gi 167963464  79 DPEQKkkqDVSLTLDTRGFSPEDVSVTVSgrrLEVMAGKRaeknass-ssaesqaQEFVQAVQLPDHLDPASLTCSLGed 157
gi 1174256    87 EGKDEk-eNFELSLDVSPFSPEELTVRTEg-rRLIVAGKSdkkretenggffqeyREWRREAELPEDVNPEDVLCSMSkn 164

                 ....*....
Feature 1        ##       
gi 46576635  123 GQLWVRGQC 131
gi 232279    164 GHLHIQAPR 172
gi 46576643  127 GHLWLRGQN 135
gi 1835585   156 GKLHIQAAR 164
gi 58037558  150 GSCASRPPG 158
gi 167963464 158 GLLHIETPE 166
gi 1174256   165 GRLHFWAPR 173

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