Conserved Protein Domain Family
ACD_HspB10

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cd06482: ACD_HspB10 
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Human (h) HspB10 occurs exclusively in the axoneme of sperm cells and may have a cytoskeletal role.
Statistics
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PSSM-Id: 107237
View PSSM: cd06482
Aligned: 4 rows
Threshold Bit Score: 130.386
Threshold Setting Gi: 149431914
Created: 29-May-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #####       # # ##                                       #                    ##
gi 145559511 116 LASSCcssNILGSVNVCGFEPDQVKVRVKDgKVCVSAErENRYDCLGSKKYSYMNICKEFSLPPCVDEkdVTYSYGlgSC 195
gi 50731804   88 YNASQd-hKVLAVMDVKGFDPEEVSVTVKDrKVQVLAEhEEAHTTTRGKEYNYKKVRKEFTLPPGVSEdeVMYSLGpnRV 166
gi 149431914   9 LVGDLdrsSVLASVDMCEFEPDQVKVKVKDgKVSVSAErENTYECLGSKNYSYMNICKEFNLPPGVDEkdVIYSFGtdNV 88
gi 126322533 115 LAASCcssNLLGSVNVCGFEPDQVKVKVKDgKVFVSAErENRYDCLGSKKYSYMNICKEFSLPPCVDEkdVTYSYGlgSC 194

                 ....*..
Feature 1               
gi 145559511 196 VKIESPC 202
gi 50731804  167 VKIETAH 173
gi 149431914  89 VKIETLC 95
gi 126322533 195 VKVEAPC 201

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