Conserved Protein Domain Family
p23_melusin_like

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cd06488: p23_melusin_like 
p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta subunits. Melusin is a muscle-specific protein expressed in skeletal and cardiac muscles but not in smooth muscle or other tissues. It is needed for heart hypertrophy following mechanical overload. The integrin-binding portion of this domain appears to be sequestered in the full length melusin protein, Ca2+ may modulate the protein's conformation exposing this binding site. This group includes Chordc1, also known as Chp-1, which is conserved from vertebrates to humans. Mammalian Chordc1 interacts with the heat shock protein (HSP) Hsp90 and is implicated in circadian and/or homeostatic mechanisms in the brain. The N-terminal portions of proteins belonging to this group contain two cysteine and histidine rich domain (CHORD) domains.
Statistics
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PSSM-Id: 107238
View PSSM: cd06488
Aligned: 17 rows
Threshold Bit Score: 142.436
Threshold Setting Gi: 190584890
Created: 25-Apr-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6017904   218 CRHDWHQTdsLVVVTVYGQIplPAFNWVKASqtELHVHIVFdg--nRVFQAQMK-----LWGVINVeqSSVFLMpSRVEI 290
gi 82083024  230 CRHDWHQTggEVTVSIYAKNsvPDLSYVEANstMLNIHIVFeg--eKEFHRNVK-----LWGVIDVkrSYVNMTaTKIEV 302
gi 82188263  228 CRFDWHQTgsQVIISIYAKNsvPELSLVEGNstVLKIHIIFeg--eKEFEKQIS-----LWGVIDPskSLVNMMaTKIEI 300
gi 82185540  229 CRHDWHQTgaGVTISIYAKNsmPELSYVEANstVVNIQVVFeg--eKTFQQNVQ-----LWGVIDVakSYVSLTaTKVEV 301
gi 156386846 230 CRYDWFQMgnSVVISVYAKLtdPNATVIKANstQLSASIIFge--aSSFDLEIS-----LYGVIDPekSEVLMSpTKVEI 302
gi 115623756 308 CRHDWHQTgkMAVLSVYCKKsePSATVVQANqvSLDIQISFnq-qkSEFRKTIKlegvrINRVIDPgsSVVNMLgSKVEI 386
gi 167876916 223 CRLDWHQTatQVVVTVYAKMchYRKSTVRLNpiRLAVCLVFpqqddQEYNVDLE-----LRGIVDVakSKVQMFgTKVEI 297
gi 74827494  213 CRYDWHQTatNVVMAIYAKKydYSQSVIELNpiRLHVNLVFpeqdnARFDLDLE-----LRGIVNVsnASAHMYgTKVEI 287
gi 190584890 217 VLYDWYQTgsNVYITIYAKLvnPERSLIEANhtIVKAFLIYgd-deKQYNKSIT-----LEGVILPekSLVQYLgTKIEI 290
gi 167517191 219 CRYDWFQSdtHVVLTVFAKCiePSRTSVKANadSITIDIVYsk--sFTFQLELH-----LGGNIIPaeSTVQLLsTKMDI 291
                         90
                 ....*....|....
gi 6017904   291 SLVKadpgsWAQLE 304
gi 82083024  303 SMRKaepllWASLE 316
gi 82188263  301 VLKKaepmsWARLD 314
gi 82185540  302 FLKKaefmtWARLE 315
gi 156386846 303 KLRKadigsWSNLE 316
gi 115623756 387 KLIKaesmsWKKFE 400
gi 167876916 298 TLIKaepghWPKLD 311
gi 74827494  288 TLPKlepgsWSNLN 301
gi 190584890 291 KLKKfdtnsWNKLE 304
gi 167517191 292 KLAKapgeaWAALT 305
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