Conserved Protein Domain Family
p23_CS_hSgt1_like

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cd06489: p23_CS_hSgt1_like 
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p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the heat shock proteins (HSPs) Hsp70 and Hsp90, and it expression pattern is synchronized with these two Hsps. The interaction with HSP90 has been shown to involve the hSgt1_CS domain, and appears to be required for correct kinetochore assembly and efficient cell division. Some proteins in this subgroup contain a tetratricopeptide repeat (TPR) HSP-binding domain N-terminal to this CS domain, and most proteins in this subgroup contain a Sgt1-specific (SGS) domain C-terminal to the CS domain. The SGS domain interacts with some S100 family proteins. Studies suggest that S100A6 modulates in a Ca2+ dependent manner the interactions of hSgt1 with Hsp90 and Hsp70. The yeast Sgt1 CS domain is not found in this subgroup.
Statistics
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PSSM-Id: 107239
View PSSM: cd06489
Aligned: 9 rows
Threshold Bit Score: 132.116
Threshold Setting Gi: 66566311
Created: 25-Apr-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1RL1_A        13 DWYQTesQVVITLMIKNvqknDVNVEFSekELSALVKlpsGEDYNLKLELLHPIIPeqSTFKVLsTKIEIKLKKpeavrW 92
gi 148222280 142 DWYQTesQIIITVMIKNvqknNVHVQLSerELTIDMNlpsGENYSLNLHLLHTILPdqSVLKVLsTKVEIKLKKteairW 221
gi 115955410  35 DWYQTdtLVTINILIKKakeeDVNIILTkiTLSATVKqptGSDYSLELDLAHPIVPekSTTRILnSKIEIRLKKeeairW 114
gi 91087931   17 DWYQTdaAVVITVLVKNvkeeNLSVNFAktCVTAKIKfpeQDDIELKFNLSHEVVPeqCSYKITpSKIEVKLKKsegirW 96
gi 66566311   23 DWYQTesHVIVPILAKSa--kNVKVIYEknTLSVSALlpsGNEYSLELDLAHAIIPeeCSHKVDpSKIEIKLKKqdgitW 100
gi 55925273  135 DWYQTesQVAVTIMVKNakkeGVIVSFGerELTAVVKlpsGEDYCLKVHLLHPIVPqqSTYKILsTKIEIKMKKteaiqW 214
gi 156382363 113 DWYQTetHVVVSVMIKNskqeDVYIEYGdqHLSVTVRlpsGNDYSLELDLAHPVSPsqCKTKILsTKIELKIKKleairW 192
gi 56756731    9 DWYQSegNVCINYFRKNlkpsDIRVEIEsrKILLYLTiptGDELLRKFHLLHDIVPekSSYRVTgTKVEIKLRKreevrW 88
gi 190584424 160 DWYQTqtTVTIDILSKKvnprDFSIDFDanSVQVTFQdqhGNSRTISFNLCHDIIPsqSKAKILtTKIEIRLKKaegiqW 239

                 ....
1RL1_A        93 EKLE 96
gi 148222280 222 ETLE 225
gi 115955410 115 SKLE 118
gi 91087931   97 AKLE 100
gi 66566311  101 TTLE 104
gi 55925273  215 EKLQ 218
gi 156382363 193 SSLE 196
gi 56756731   89 SHLE 92
gi 190584424 240 TNLT 243
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