Conserved Protein Domain Family
p23_NCB5OR

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cd06490: p23_NCB5OR 
p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining viable pancreatic beta cells. Mice homozygous for a targeted knockout (KO) of the gene encoding NCB5OR develop an early-onset nonautoimmune diabetes phenotype with a non-inflammatory beta-cell deficiency. The role of NCB5OR in beta cells may be in maintaining or regulating their redox status. Proteins in this group in addition contain an N-terminal cytochrome b5 domain and a C-terminal cytochrome b5 oxidoreductase domain. The gene encoding NCB5OR has been considered as a positional candidate for type II diabetes and other diabetes subtypes related to B-cell dysfunction, however variation in its coding region does not appear not to be a major contributor to the pathogenesis of these diseases.
Statistics
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PSSM-Id: 107240
View PSSM: cd06490
Aligned: 10 rows
Threshold Bit Score: 115.507
Threshold Setting Gi: 190584960
Created: 25-Mar-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121944420 170 YDWFQTDsLVTIAIYTKQKdi-nLDSIIVDHQndSFRAETIIk-dCLYLIHIGLSHEVQEdf-sVRVVESvGKIEIVLQK 246
gi 118088774 172 YDWFQTDdMITVVIYTKQKgm-nAELVIVDCQdrRLRGEIILd-dHSYLVEVDLDREVQGdf-aVNIGEKvGKVEIILKK 248
gi 123892457 172 YDWFQTEsLVTVAVYTKMKnv-cSELVIVDHLenVLRGEIIIg-dYSYLLHSELSHPVQKdi-eVKVSATaGKIEIKMKK 248
gi 156324919  71 YDWYQNDrIVTIAVYTRAKdiqmDSIILELKDqkDLNAIFILg-eKSYQLHLDLEEKVSNq--qVRIANDtGKVDLLLTK 147
gi 66472432  178 YDWFQTDgTVNIVVYTKRKip-sAGCAVVDLQddNLRVEMLLg-rMSYLLYWRLSSRVQDhv-dVQTAHSvGKVQLCLRK 254
gi 190584960 208 YDWYQSDkSITIVVYTKHKgltnEDILVNVKNnrKTDIWIVLg-dKILQLCLDLFEEICEs--eVKISTE-GNIEVILLK 283
gi 125807293 191 FDWIQQRsELTLFFYTRSFsn-pGLIVRRKDPq-QLVARVFLe-sRWHTFDLQLAGKVEWppkaVRVGTEtGKIELVLAK 267
gi 66771089  190 FDWIQQRsELTLIFYTRSLan-pGLVVRRKDLq-QLSVRVLVq-hNWHSFDFQLTNNVEWppklAKIGSEtGKIELVFVK 266
gi 170066947 156 FDWIQKTaEVSFIFYTRALcn-pAVIVELVNNl-EFNVRFFLegnVLHRYRFQASNNLQWpc-tVRQSLEtGKVEIVFNK 232
gi 158287260 149 FDWIQKTaELTLIFYTRSLan-pGVMVECVDHl-EVTVNILLessVQHRYRFHLANNVRWpc-tVRTSLEsGKIELMFNK 225
                         90
                 ....*....|..
gi 121944420 247 ken--tsWDFLG 256
gi 118088774 249 kdr--iqWKVLG 258
gi 123892457 249 kep--vsWKSLG 258
gi 156324919 148 depesqfWECTL 159
gi 66472432  255 svk--ekWTQLG 264
gi 190584960 284 qei-gkkWLSLG 294
gi 125807293 268 eep--apWSSYG 277
gi 66771089  267 eea--epWPTYG 276
gi 170066947 233 llp--glWTNYG 242
gi 158287260 226 lcp--alWTSYG 235
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