Conserved Protein Domain Family
p23_mNUDC_like

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cd06492: p23_mNUDC_like 
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p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation.
Statistics
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PSSM-Id: 107241
View PSSM: cd06492
Aligned: 17 rows
Threshold Bit Score: 147.487
Threshold Setting Gi: 114052643
Created: 29-Jun-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2CR0_A        20 YRWTQTLaELDLAVPFRVsfrlKGKDVVVDIQRRHLRVGLKGQPPVVDGELYNEVKVEeSSWLIEdgKVVTVHLEKINKM 99
gi 94469366  167 YTWTQTLqELELRVPFDVkftlKAKDVVVNIQRKSLKVGLKGHPPVIDGELHADVKMEeSLWHLDk-NTVVVTLDKINQM 245
gi 21356395  173 YTWTQTLeEVELKIPFNLtfglRARDLVISIGKKSLKVGIKGQTPIIDGELCGEVKTEeSVWVLQdsKTVMITLDKINKM 252
gi 114052643 169 YKWTQTLeEVEIRVPLRQi--lRPRDLTVVINKKHLKVGIKGQPLIIDGELDADVKIEeSTWVLQdgRNLLINLEKVNKM 246
gi 17553534  161 YQWTQTLqELEVKIPIAAgfaiKSRDVVVKIEKTSVSVGLKNQAPIVDGKLPHAIKVEnCNWVIEngKAIVLTLEKINDM 240
gi 66518451  176 YRWTQTLqDLEIKVPLKVnfsaRPKDVSVTITKKRLTCGIKGQPPIIDGDFPHEVKVEeSTWVIEdgKVLLLNLEKVNKM 255
gi 156399969 157 YKWTQTLeEIELRIPLDVsfkpKGKDVVVDIQQKHLKAGLKGHPPIIDGDFPKKVKLEeCTWLIDg-KNLVLNLEKVNKM 235
gi 29841027  170 YSWYQTLsEVDIKIPTRLphriKCRDVYVEIARRHIKIGLKNQEPILCGKLYNEVKVEeSSWTLLdgLVISVNLEKINKM 249
gi 190585101 162 YKWTQTLsDVELRVPFKVsfpvKGKDVICEIKPNHLKIGLKGHEPIIDGDLHKTIKIEnCYWVIEdkKAVMVTIEKVNKM 241
gi 193577869 165 YRWTQTLsDIELKIPSKAafklRPRDVIVNLKKKHIFVGIKGQPPILDDELQHEIKLEeTTWLLEdgKTFLINIEKVNKM 244

                 ....*..
2CR0_A       100 EWWNRLV 106
gi 94469366  246 NWWDRLV 252
gi 21356395  253 NWWSRLV 259
gi 114052643 247 NWWGRLV 253
gi 17553534  241 EWWNRFL 247
gi 66518451  256 QWWAHVV 262
gi 156399969 236 EWWSQLV 242
gi 29841027  250 EWWPRIC 256
gi 190585101 242 EWWPRLV 248
gi 193577869 245 EWWSKLV 251
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