Conserved Protein Domain Family
ACD_alphaA-crystallin_HspB4

?
cd06497: ACD_alphaA-crystallin_HspB4 
Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaA-crystallin (HspB4, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Alpha crystallin, an abundant protein in the mammalian lens, is a large (700 kDa) heteropolymer composed of HspB4 and HspB5, generally in a molar ratio of HspB4:HspB5 of 3:1. Only trace amounts of HspB4 are found in tissues other than the lens. HspB5 does not belong to this group. Mutations inHspB4 have been associated with Autosomal Dominant Congenital Cataract (ADCC). The chaperone-like functions of HspB4 are considered important for maintaining lens transparency and preventing cataract.
Statistics
?
PSSM-Id: 107245
View PSSM: cd06497
Aligned: 4 rows
Threshold Bit Score: 175.179
Threshold Setting Gi: 6014724
Created: 18-Mar-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #####     # # ##                                    #                    ## 
gi 117346   60 GISEVRSDRDRFVIYLDVKHFSPEDLTVKVLdDYVEIHGKHSERQDDHGYISREFHRRYRLPSNVDQSaISCSLSaDGML 139
gi 6014722  61 GMSEVRSDRDKFMVYLDVKHFSPEELNVKVAeDYVEIQGKHGERQDDHGYISREFHRRYRLPSNVDQSaITCTLSaDGQL 140
gi 6014724  60 GISEVRSDRDRFTINLDVKHFSPDDLTVKILdDFVEIHGKHSERQDDHGYISREFHRRYRLPSNLDQSsISCSLSaDGIL 139
gi 117344   60 GISEVRSDRDKFTIMLDVKHFSPEDLSVKIIdDFVEIHGKHSERQDDHGYISREFHRRYRLPANVDQSaITCSLSsDGML 139

               ....*.
Feature 1            
gi 117346  140 TFSGPK 145
gi 6014722 141 TICGPK 146
gi 6014724 140 TFSGPK 145
gi 117344  140 TFSGPK 145

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap