Conserved Protein Domain Family
TA_like

?
cd06502: TA_like 
Click on image for an interactive view with Cn3D
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Statistics
?
PSSM-Id: 99748
View PSSM: cd06502
Aligned: 17 rows
Threshold Bit Score: 320.434
Threshold Setting Gi: 16127323
Created: 18-Jul-2008
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1LW4, Thermotoga TA with bound PLP
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1LW4_A        7 DLRSDTVTKPTEeXRKAXAQaevgdd-vygedpTINELERLAAETfg-keAALFVPsGTXGNQVSIXAHtqrgdEVILEA 84
gi 17230788   7 QFASDNYAGICPeAMNYMIQanqgsapaygndeWTQKATDYFRELfeidcEVFFTFnGTAANSLSLAALcqsyhSVICHE 86
gi 18202997   7 QFASDNYSGICPeAWAAMAEanrgheraygddqWTARASDYFRQLfetdcEVFFAFnGTAANSLALAALcqsyhSVICSE 86
gi 15891166   2 FFASDNWAGAHPaVNERLSRestrfaaaygtseLDLSIEKRFNEIferevAVFFVAtGTAANSLSLASIarpggLTFCHS 81
gi 17549337  15 GFTSDNIEGASPeVLDAILAanagqaapygaddCTARVEQTLSELferevKVFLVPtGTAANALCLGAMtppwgNVYCHP 94
gi 5354192    5 RFFSDNAATVAApVMDAIIAanqsdm-aydsdkWSQKLDAIFSELfgtdvTAHWAVtGTAANALSLSAIcppfgGVLCSQ 83
gi 21219602  18 GFASDNYAGAHPeVLAALALangghqvaygeddYTENLQRVIRSHfgsgaEAFPVFnGTGANVVALQAVtdrwgAVICAE 97
gi 16127323   9 DFASDNVAGAMPeVMEALIAanagtasgygtdhVSRAAADRIRAAldadaQVRFTAsGTAANAFALTLLaqpheAVLAHE 88
gi 2501217    3 DLRSDTVTRPSRaMLEAMMAapvgdd-vygddpTVNALQDYAAELsg-keAAIFLPtGTQANLVALLSHcergeEYIVGQ 80
gi 15791224  22 DLRSDTVATPTEaMREAAAQapvehg-ehgddpAVAAVEATAADAvg-maAAVFVPsRTMANQIGAQVHtargqSVLVER 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1LW4_A       85 dSHIFWYEVGAXavl-sgvXPHPVpgkn-gaxDPDDVRKAirprn---ihfprTSLIAIENTHNrsggrvvplenIKEIC 159
gi 17230788  87 tAHIETDECGAPefasngsKLLLAkgen-gklTPQEIESVitkrvd--ihypkPKVISITQATElgtly--sieeLLDIK 161
gi 18202997  87 tAHVETDECGAPeffsngsKLLLAqtev-gklTPASIRDIalkrqd--ihypkPRVVTLTQATEvgtvy--rpdeLKAIS 161
gi 15891166  82 eAHVIEDECGAPdff-sgmRMVAVegpd-gkmLPENLIERiarypqdavhhgrAAAITMTQATEagtvy--tldeIDAIS 157
gi 17549337  95 sSHINNDECGAPefytngaKLVAVdgps-akiDVEKLRAAtrvkvg-dvhstqPACVSLTQATEvgsly--tlneIEAIG 170
gi 5354192   84 dAHVQTDEGGAPefytggsKLLLVpgeg-akiTPEALKTRaeaiad-svhmvqPHAVTITNSTElgqvy--tpeeTAAIG 159
gi 21219602  98 sAHINVDEGGAPerm-gglKLLTVptpd-gklTPELIDRQaygwdd--ehramPQVVSITQSTElgtly--tpdeIRAVC 171
gi 16127323  89 hAHICTDETGAPgffgqgvGLIGLpgas-gkmELAALEAAlaqpdv--syrqpAAALSLTTATEygtvy--sedhLRALI 163
gi 2501217   81 aAHNYLFEAGGAavl-gsiQPQPIdaaadgtlPLDKVAMKikpdd---ihfarTKLLSLENTHNgkvl---preyLKEAW 153
gi 15791224 100 aSHSYRRGSGGLaqh-agvQARAFdggetgcpTAEQVAAEitagg---ghrpeVGLACVEIAHGanggvvapvdaFAAAV 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                    #                                  
1LW4_A      160 TIAKehgINVHIDGARifnasiasgv--pvkeyagyaDSVXFCLSXGLCApVGSVVVGDrDFIERARKARKXlgggxrqa 237
gi 17230788 162 KVAQkyqLKIHMDGARfanavaamnkspaemswksgvDVLCFCGTKNGMAlGEAIIFFNrALAEDFDYRCKQagqlaskm 241
gi 18202997 162 ATCKelgLHLHMDGARfsnacaflgcspaelswkagvDVLCFGGTKNGMAvGEAILFFNrDLAEDFDYRCKQagqlaskm 241
gi 15891166 158 KIAKengLPLHMDGARfanalaalgttpaemtwkrgvDVLSFGGTKNGCWcAEAIVFFDpSLARDFSFLRKRtaqlfsks 237
gi 17549337 171 QLCKdarIKLQMDGSRfanalvslgcspaamtwkagvDALSFGATKNGVVaAEAIVLFDlSLAAEMGYRRKRaghlfskm 250
gi 5354192  160 AVARekgLRFHLDGARfanavaalgcnpadltwkagvDLMSFGFTKNGAMaAEAIVFFDrELAAHNKRRRKRaghllskg 239
gi 21219602 172 EHAHahgMKVHLDGSRianaaasldvpmrtftnavgvDLLSLGGTKNGALfGEAVVVLNqDAVRHMKHLRKLsmqlaskm 251
gi 16127323 164 APVKakgYGVHLDGARlanavaggfd--lksiakmgvDILVMGGTKAGSTpTEAVVFLNpDHAKRLDARLKHagqliskg 241
gi 2501217  154 EFTRernLALHVDGARifnavvaygc--elkeitqycDSFTICLSKGLGTpVGSLLVGNrDYIKRAIRWRKMtgggmrqs 231
gi 15791224 176 ETAHehdVPVHVDGTRvfsaatalgv--daatllspvDSVAVCLSTGLGApMGAVLAGSeSFVASARRVQEMygggmqqa 253
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                       
1LW4_A      238 GVLAAAGIIALTk------xVDRLKEDHENARFLAlklkeigysvnpedvktNXVILRtdnlkvnAHGFIEALRns---- 307
gi 17230788 242 RFISAPWLGLLEtg----awLKNAQHANQCAAYLEnell----------kieGVEIMFpr---evNAVFVKLPEqvingl 304
gi 18202997 242 RFLAAPWVGVLQdd----awLRYADHANRCARLLAelva----------dvpGVSLMFpv---eaNGVFLQLSEpaieal 304
gi 15891166 238 RFIAAQFEAYLQdd----lwLGLAGHANAMANRLRagfg----------slnSARLAWpt---qaNEVFAILPKaaaeaa 300
gi 17549337 251 RFLSAQIEAYLAnd----lwLRNARQANDMALRLArgle----------gmhGASVLGat---eaNIVFCRLPStlienl 313
gi 5354192  240 RFIAAQIEAMLKnd----lwLDLARSSNTVAKRIAea-------------vdPKRHAYpv---kaNEVFLFISMeerael 299
gi 21219602 252 RFVSVQLEALLAkd----lwLRNARHSNEMAQRLAegvr----------avhGVEILYpv---qaNAVFARLPHevser- 313
gi 16127323 242 RFLAAPWLGLLGengqtapwAARAAHANAMAQKLAal--------------mPVPIKHpv---eaNGIFVEMDElalerl 304
gi 2501217  232 GILAAAGIYALKn------nVARLQEDHDNAAWMAeqlreaga--dvmrqdtNMLFVRvge--enAAALGEYMKar---- 297
gi 15791224 254 GMVAAAGVCALEn-------RHRVHEDHENARRLAedldalpg-vtaaepdtNIVLADtr---daDVTAAAFLAgce--- 319
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         
1LW4_A      308 ---gVLANAVsd------------tEIRLVTHkdvsrNDIEEALNIFEKL 342
gi 17230788 305 kannWLFYTFig-----------vgGVRFMCSwnttkSRIDELVGDIKTG 343
gi 18202997 305 rargWRFYTFig-----------egGARFMCSwdtdiERVRELARDIRLV 343
gi 15891166 301 tqkgAKFYDWleprdmpenvgkdevLIRMVTSfatteADVDEFLSICAAV 350
gi 17549337 314 lqagFRFYHNrwe----------pnVVRFVTSfattaDDVDNLLRHMKAA 353
gi 5354192  300 rkqgFVFYDWgh------------dKIRLVASwdqpeHEVVALEKALKAL 337
gi 21219602 314 lqkrFRFYFWdea----------agDVRWMCAfdtteNDVDAFVSALKEE 353
gi 16127323 305 rgegWFVYRFld------------gTVRFMCSwattpEMVEDLGAALKRV 342
gi 2501217  298 ---nVLINASp--------------IVRLVTHldvsrEQLAEVAAHWRAF 330
gi 15791224 320 --eeGVLGTAdg-----------eyTVRFCTHrdiggADIAAVVSAAGEV 356

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap