Conserved Protein Domain Family
GH25_AtlA-like

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cd06522: GH25_AtlA-like 
AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml autolysins from Streptococcus mutans which have a C-terminal glycosyl hydrolase family 25 (GH25) catalytic domain as well as six tandem N-terminal repeats of the GBS (group B Streptococcus) Bsp-like peptidoglycan-binding domain. Other members of this family have one or more C-terminal peptidoglycan-binding domain(s) (SH3 or LysM) in addition to the GH25 domain.
Statistics
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PSSM-Id: 119382
View PSSM: cd06522
Aligned: 12 rows
Threshold Bit Score: 242.276
Threshold Setting Gi: 28377553
Created: 25-Jul-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #                           #                            # #                
gi 166157380  773 SYFIDISSHNGiisvaef-nslkqqGIQGVVVKLTEGTSYINPYASSQIANARAAGIKVSAYHYAHYtsaagAQEEARYF 851
gi 29376682   164 KNFIDVSSWNGdisvaey-qkiksyGVTGVSVKLTEGTWYVNPYAAGQIRNAKAAGLKVSAYHYSMYvsaatAQDEARYF 242
gi 116618508   44 MDVVDVSSNNGtisvady-kkmqnyGVKAVIVKLSEADSYKNPYAKSQITNAKEAGLQVGAYHYSWYaskadAQAEAKYF 122
gi 125623106   92 QDAVDISDYQNwmvqsdf-nalkseGVKTAIIKLTEGTSYLNPSAAKQILMAKNAGLTVATYHFVYDpt--kIQNEAAFY 168
gi 28849823   152 KTFVDVSSHNGsisvndy-rtlankGVGGVVVKLTEGTTYRNPYAGEQARNAQLAGLQVSAYAFSHYtseeqARAEARHF 230
gi 15487801    46 KDFIDISSNNGsiskdefqlmknqyGIKGVIVKLTEGDSYCNPLAPEQIANAQAAGLKVSVYHFSWFanpqeAAEEATYF 125
gi 116493957    3 ILMADVSSWQPesdswf--rkladvGVKAVVVKLTEGTTYRNPKAAAQLAAGRRMGMQVHGYHYAHYhnsadAVAEGRFF 80
gi 116333708    4 YDVVDTSNNNGimtvanw-rsmkkyGVKAMIAKLSEGTYFTDQTAKPSIRNAITAGLHVNGYHFARFttetgAKAEAQMA 82
gi 28379506   229 VDVVDVASYQStmtqsdf-nklkaaGVKTVIVKSTEGTDYTNPAALNQAKMANKAGLNVDFYHYATFstadaAKSEATNM 307
gi 116493807  115 VDTVDVASYQNgmtqany-nslrasGVKAVIVKSSEGSTYRNPYAAKQLAQAKAAGLKTAVYHYVHFanqsdAIAEANYF 193
gi 28377553    31 MDMVDVSNNNGymstaeyvsmrnefGVRALTVKISEGTTFKDGYAASNIANGQAAGLYVNSYHFAHYktkaqAIAEADFA 110
gi 199599657   14 NDVVDVSDWQSwmtqndy-tqlhnlGIKGVVVKVTEGTYYTNGIAANQIKFARNAGMVVSAYHYATFdsasaAVAEANYF 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          # #                                  #                         
gi 166157380  852 ANAARSFGLEASTVMVNDMEessm-----vnniNNNVQAWQDEMRRQGYsNLIHYTMASWldirggq----vytarfGIN 922
gi 29376682   243 AQAAANSGLDKNTIMFNDAEdptltn--ngrnaHANSVAFNQQLKALGYkNDALYVGKWWltngyi------dtsafGRD 314
gi 116618508  123 TNYAASLELPKDTLMVDDLEesytk----nssvTANATAFNAQVKAAGYtNTSTYTYVSYvnetnl------nfsyiGNN 192
gi 125623106  169 AQSAKALGLSTNTVMIEDAEapsq-----yynwTAVSQVFKSTMNKAGFnNIRYYTSQGWvssgvm------nastlGAK 237
gi 28849823   231 ISEARNLNLPKNTVMVNDMEdakm-----kdniNRNTLAWADEMRKNGYtNLMYYTSASWidennlrgkgpvktaqfGLE 305
gi 15487801   126 MNYAKELELAQNTSFVNDYEsvns------pnaTSNALKFADTLKAAGFkNVYHYSSKSWfssvl-------dmtklGAK 192
gi 116493957   81 GTTAKALGLSTESVMAADVEdpgl-----sgelTGLTNVFLQTVKAIGYpHTDLYTMASWlttrrf------drvalIPK 149
gi 116333708   83 ARSALKAGLGKSSVIVLDFEatnsg----wnqnSKIVKAWINEVHRMGYpKTDVYTMGSWinsv---------plnnSGR 149
gi 28379506   308 AGFLVKNNVSTKVLLFADMEdsssy----svnaTANLNAFWSTLDSFGYkNHGVYTSNSYlyrda-------vvktvGQS 376
gi 116493807  194 ANTLDSLGFSKTSPVVADIEdsdv-----ggdvAANVNAFWNVLSTRGYvNHIVYTGLYYsyska-------aistvGNE 261
gi 28377553   111 GQTAKAAGLPVGAVLATDVEsaeeqeilsqatnDRNNAAFMKEIQKFGY-RADIYTSGSWannk----------mtiKSK 179
gi 199599657   93 ANRLDSLNVGKNVTVVADIEsdav-----sgdiAGNLKAFWQTMTQRGYqNHVAYTMRYYkhlda-------ltsttGKD 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1           #                            #                  #     
gi 166157380  923 NFWVAHYakgytymtqeeakslnyyanAAAWQYTSvssk------lshaLDENIDY 972
gi 29376682   315 RVWVAQYpytpdss-------mqwnndHGAWQWSSqmyfpglanyegrpFDISMTY 363
gi 116618508  193 RVWMAQYpyqpsas-------slwnqsYGMWQWNSntsfp----gvkgtFDVSIDY 237
gi 125623106  238 NLWVAQYlygkpsn------qnlkntdYGSWQYTSqmyyqstpnlrshnLDTSIDY 287
gi 28849823   306 NFWVAQYptaklsand--aktlryngrAGAWQFTSqaell----pgkhvFDHSVDY 355
gi 15487801   193 TCWVAEWplnpsnd-------qllhtgNASWQWASdlyfpe--lgrtrqFDISTDY 239
gi 116493957  150 NLWLASYgvnqp-----------gvdnVGTWQFTNnfq--------glgVDMSYDF 186
gi 116333708  150 GGWVANYpynpsg--------fklytgYNGWQWTSsmhfp----gcyggFDVSQMY 193
gi 28379506   377 RVWRAQYpytpsan-------nlwntnDGAWQFSDtallpsg-sdytgyIDVSIDY 424
gi 116493807  262 RAWVAQYpyvpsvd-------nllntgYGAWQFSSmagip----nyngrVDVSIDY 306
gi 28377553   180 TGWVAGYpyvmsg--------qkwytnNNAWQWSGsahfr----isyggFDVSQLY 223
gi 199599657  161 RTWIAQYpytpsan-------slwdqdFGAWQFSStghlp----ghsqnLDVSIDY 205

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