Conserved Protein Domain Family
GH25_Lyc-like

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cd06525: GH25_Lyc-like 
Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.
Statistics
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PSSM-Id: 119385
View PSSM: cd06525
Aligned: 15 rows
Threshold Bit Score: 226.409
Threshold Setting Gi: 182418596
Created: 28-Jul-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #                        #                            # #                    
gi 462559      2 KGIDIYSGqg-sVDFNAVKesGVEVVYIKATEGLTYTDSTYKDFYDGAKNAGLKIGFYHYlra---ndPTSEAEHFFNTi 77
gi 168214653  10 KGIDISNWqk-gINLNQLKerGYDVCYIKITEGKGYVDPCFEENYNKAIAAGMKVGVYHYwrg--tssAIEQANNIVRTl 86
gi 20141459   10 KGIDVSNWqg-nINFKSVKneGIEVVYIKATEGDYFKDSYAKQNYKRAKAEGLKVGFYHFfkp--nknAKRQAKYFIDYl 86
gi 170758235   2 KGVDISNNnqrpIDFNKIKasGVEIVYLKATEGTTFKDPYCNEYYNRAKAAGLKVGLYHFlvg--tsaPESQAENFYSMh 79
gi 153932341   3 KGIDISMHng-tVNFSAVKssGCNIVIIKATEGVNYVDPCLNQHYNGAKAQGLNIGFYHFmse--ktnPTQQAIDFWNAi 79
gi 164686315   5 RGIDVSNWsg-yINWREVRdaGIEVAIIQASEGTFYRDPYLHEFYNGAKENGIKVGFYHFfnpgssptPSEQARYFVDTi 83
gi 188588405   2 KGIDISNHng-eIKFASVKssGVELVYIKATEGTTYQDPMLNQYYNGANSEGLRTGFYHFlvg--tsaPESQAQNFYDNi 78
gi 182416939  49 KGINISNNdg-nLDLSSVTqaGGKYVYLKATEGATFRDSYMDTYYNQCKDLGMKIGVYHYlvn--tssPEEQAENFYNTi 125
gi 118443295  10 NGIDISNWqs-gINYDKLKr-NTEVVIIKATEGVDFIDKMFLTHYNGCKTAGLKIGFYHFfsd--ksnPTKQARDFWNTi 85
gi 160940955  33 QGMDVSSWqg-dIDFQAVRaaGIQVVYLRAGVGLEYVDPYFQSNYEKALDAGLNIGYYHYvtaadtfqARQQAEFFYSLi 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      # #                                #                      #       
gi 462559     78 sg---lslDCKCAIDVEvtlgq-sidqiSSNVRKFADYLINK-GLDVCVYTYTNFykdnln---stvkdLPLWIAEYGvs 149
gi 168214653  87 gn---khiDCKIAIDVEqtdgl-sygelNNSVLQLAEELERLiGAEVCIYCNTNYarnvld---srlgkYSLWVAHYGvn 159
gi 20141459   87 neigatdyDCKLALDVEttegr-sayelTTMCIEFLEEVRKItNREVVVYTYTSFannnld---nrlgvYPLWIAEYGvk 162
gi 170758235  80 kg---ktlEVLSNLDIErnn-----fnvMDYAIRFIKRFKELsGRNISIYAGPYFindnld---srlkqYPLWVAHYGvn 148
gi 153932341  80 kg---kqfNIIPTLDIEtnnmgrsqkqiSDRCIEFLTKFKALsGYNCLIYTGGYFgrdnld---sriksYPGWIAHYGvd 153
gi 164686315  84 rg---ldsDLKLVLDLEqtggl-dnyevTRQAIEFLEEVRNYsGLDVAIYTYTNFaqynlye-glglseYPLWIAQLSeg 158
gi 188588405  79 kg---ktnDLKPCLDIEkng-----fdvMDFALRFIKKFESLsGLPLCIYSYPYFinnnld---srlakYPLWVANYGvq 147
gi 182416939 126 sk---ynwDLIPMLDTEvyf-----dglEDYIKRFKIAFNKLsPLKLGIYSYTSFidkylnnadseiyeMPLWEANYNgk 197
gi 118443295  86 kn---kkmHVIPVLDIEtskrs--ktevTNRCLEFLKEMERLsGFKCIIYTYTSFaiekld---krlssYPLWIAHYGva 157
gi 160940955 112 rd---kqiDCCPAMDFEsfpgl-stqeiNAIGLSFMETLGSLlGYDPALYTDSYNaaylws---sdfssYPLWVADYDvn 184
                        170       180       190
                 ....*....|....*....|....*....|....*...
Feature 1                        #                #    
gi 462559    150 kpn-----idasYVGFQYSDSGSVNGis--gsADLDEF 180
gi 168214653 160 kpgd--npiwdkWAGFQYSENGTSNVng---sLDLDEF 192
gi 20141459  163 apkd--nrvwssWIGFQYSDKGNVAGvs--gnCDMNEF 196
gi 170758235 149 kpman-kvwgssYAGHQFTEHGTIPGip--giCDVNNF 183
gi 153932341 154 kpm----qtgfpVVGHQYTETGRVNGvs--gnVDLNNF 185
gi 164686315 159 gpspn-piwgnkYVAWQYSDTGRVRGin--asTDLDLV 193
gi 188588405 148 tpipn-nvwgdsYVGHQYSETGNVNGin--gnVDLDTF 182
gi 182416939 198 pwssvgdnkftnLVGHQYSTEKHISDyigdfnGDLNEF 235
gi 118443295 158 sphn--ngiwnkWVGFQYTDKARIEGvp--ntCDANKF 191
gi 160940955 185 qpes--tgpwdsWDGFQYSDRGRVPGvn--gdVDMDFF 218

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