Conserved Protein Domain Family
metazoan_ACD

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cd06526: metazoan_ACD 
Click on image for an interactive view with Cn3D
Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.
Statistics
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PSSM-Id: 107247
View PSSM: cd06526
Aligned: 129 rows
Threshold Bit Score: 48.6703
Threshold Setting Gi: 149431914
Created: 25-Jul-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative dimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #####           # # ##                                        #                 
2BOL_A       222 GLEIVtaedgskKIHLELKVDPhFAPKDVKVWAKgnKVYVHGVtgkeektenashsehREFYKAFvTPEVVDAskTQAEI 301
2BOL_A       102 DAYEVgkd-grlHFKVYFNVKN-FKAEEITIKADknKLVVRAQksvacg----daamsESVGRSIpLPPSVDRnhIQATI 175
gi 76155537   33 EMGEDgk----vHFNLRFDVKG-FEPEDIKVTLTdnYIKVQAKketkak----gssscREFCRLVeLPKSVDHdqLTCNL 103
gi 129359    132 EVGEDgk----vHFKVRFDAQG-FAPQDINVTSSenRVTVHAKketttd----grkcsREFCRMVqLPKSIDDsqLKCRM 202
gi 13625983   97 EPGEDgr----vHFKVRFNVEG-YGPEDIQVNTSehGLTVHAKksvkde----kgtrmREFFRTIyLPPSVDKdhFQANM 167
gi 56752663  249 ELGDDgk----vHFKVRFDAKD-FAPEDIEVTTVdnHLRVHAKksiksg----sttteREFRRSIdLPRSIDHehFQCHL 319
gi 93211210   38 TPLSD-------DYEVSFDVKS-SKPEEIEVKVKdrTIHVEAKheered---elgfvsRQFARRFvLPQEFDPetISTFL 106
gi 156401745  10 AKKESkd----dKFSMAMDVKG-FPPEAIKVQVLgnELLVSANhevehe----ghyhaMHFNRQFiLPREVDMdsLTTRL 80
gi 156363677  21 ATKDDt------KFTLALDVSD-FKPEEVDVKVYghELSVRARqeseeh----gfftaRQFNRHFvLPREVDMdtLVPRL 89
gi 150021828  68 ALSTSq------YFQIRFDLSS-YKPENIRVVVRsgDVIVEAEhestcd----sysetETLRRRIrLPDKVDQsmLTSVL 136
                         90
                 ....*....|..
Feature 1           ##       
2BOL_A       302 Vd-GLMVVEAPL 312
2BOL_A       176 TtdDVLVIEAPV 187
gi 76155537  104 TndGVLRLEAPV 115
gi 129359    203 TddGVLMLEAPV 214
gi 13625983  168 TedGILTLEAPV 179
gi 56752663  320 TedGVLILDAPV 331
gi 93211210  107 NaeGKMTIKAAK 118
gi 156401745  81 DkeGKLHFEAKK 92
gi 156363677  90 AkdGVLYIEADK 101
gi 150021828 137 NaeGEMTIQAPF 148

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