Conserved Protein Domain Family
CIDE_N_ICAD

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cd06536: CIDE_N_ICAD 
Click on image for an interactive view with Cn3D
CIDE_N domain of ICAD. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD (DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40 and ICAD/DFF45 during apoptosis. In normal cells, DFF exists in the nucleus as a heterodimer composed of CAD/DFF40 as a latent nuclease and its chaperone and inhibitor subunit ICAD/DFF45. Apoptotic activation of caspase-3 results in the cleavage of DFF45/ICAD and release of active DFF40/CAD nuclease.
Statistics
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PSSM-Id: 119369
View PSSM: cd06536
Aligned: 5 rows
Threshold Bit Score: 147.638
Threshold Setting Gi: 50540330
Created: 21-Feb-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
CAD/ICAD
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:CAD/ICAD heterodimer interaction site [polypeptide binding site]
Evidence:
  • Structure:1F2R_I; Mus musculus CIDE-N domains of CAD and ICAD form an assymetric heterodimer.
    View structure with Cn3D
  • Comment:Although the CAD and ICAD CIDE-N domains are structurally similar, they bind one another asymetrically using different surfaces from each protein.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                        # ##### ##                  # #
1F2R_I       17 PLKPCLLRRNHSRDQHGVAASSLEELRSKACELLaidksltPITLVLAEDGTIVDDDDYFLCLPSNTKFVALACNEKWTY 96
gi 47228821   4 DKKPCRVCNFTRQKSYGVAVPSLMELKTKGSEFLgfr-ssdPVTVVLEDDGTIVADESYFLCLPPNTKFMLLHEKEMWAP 82
gi 50540330   3 ELKPCKVCNVSRQKCYGLAVTSLDQLRIKGAESLgfc-psaSVSVVLENDGTIVEDEAYFMCLPANTKFMLLDANEIWMH 81
gi 50759301   4 RLKPCVVRRGDGREQHGLAASSLRELRDKAGSALaigedgrPITLVLAEDGTIVDDEDYFLCLPSNTKFVALAEGERWSG 83
gi 60416006  19 FQKACVVSLPGSKDRHGVAAASLEELLEKACKKFsldssvePITLVLAEDGTIVEDEDYFLCLPPNTKFVILTGNKKWAP 98

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