Conserved Protein Domain Family
CIDE_N_FSP27

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cd06538: CIDE_N_FSP27 
CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, N-terminal) domain is found in the FSP27/CIDE-C protein, which has been identified as a n adipocyte lipid droplet protein that negatively regulates lipolysis and promotes triglyceride accumulation. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. The CIDE-N domain of FSP27 is sufficient to increase apoptosis in vitro when overexpressed.
Statistics
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PSSM-Id: 119371
View PSSM: cd06538
Aligned: 5 rows
Threshold Bit Score: 153.048
Threshold Setting Gi: 2829467
Created: 25-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative heterodimer interaction sites [polypeptide binding site]
Evidence:
  • Comment:Based on the CAD / ICAD CIDE_N domains.
  • Comment:Although the CAD and ICAD CIDE-N domains are structurally similar, they bind one another asymetrically using different surfaces from each protein.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #        ## ##         #   #              # ##    ##                  # #  
gi 149728303  41 RTRPYRVSTADRSVRKGIMAHSLEDLLHKVRDTLtladkPFSLVLEEDGTTVETEEYFQALADNTVFMVLQKGQKWQPPS 120
gi 2829467    41 RARPCRVSTADRKVRKGIMAHSLEDLLNKVQDILklkdkPFSLVLEEDGTIVETEEYFQALAKDTMFMVLLKGQKWKPPS 120
gi 50415289   37 KPRPYRVCNNDRSLRKGIMADSLEDLINKTLDALll-neAITLVLDEDGTCVDTEEFFRSLEDGAVFMALGKGQKWKSTE 115
gi 113682169  36 HSRPFRVINSDRSIKKGIMADDLEDLHHKVMDVFhi-hcISALVLDEDGTGIDTQDFFQTLKDNTVLMVLGKGQKWAPQT 114
gi 47218977   48 RLRPFRVTNAERSLKKGIMAFSLEDLMNKVGDSLnv-lcISDVVLDEDGTGVDTEGFFQALPENAVLMVLEKDQRWTPDT 126

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