Conserved Protein Domain Family
CIDE_N_A

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cd06539: CIDE_N_A 
Click on image for an interactive view with Cn3D
CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45, and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, the CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.
Statistics
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PSSM-Id: 119372
View PSSM: cd06539
Aligned: 5 rows
Threshold Bit Score: 145.472
Threshold Setting Gi: 147899788
Created: 26-Jun-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative heterodimer interaction sites [polypeptide binding site]
Evidence:
  • Comment:Based on the CAD / ICAD CIDE_N domains.
  • Comment:Although the CAD and ICAD CIDE-N domains are structurally similar, they bind one another asymetrically using different surfaces from each protein.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1             #        ## ##         #   #              # ##    ##                  # #
2EEL_A         8 PARPFRVSNHDRSSRRGVMASSLQELISKTLDALVIatgLVTLVLEEDGTVVDtEEFFQTLGDNTHFMILEKGQKWMP 85
gi 9087119    33 PARPFRVSNHDRSSRRGVMASSLQELISKTLDVLVIttgLVTLVLEEDGTVVDtEEFFQTLRDNTHFMILEKGQKWTP 110
gi 147899788  40 PQRPFRVSNYDRSSKKGIVAGTLKELIEKASETLFIhsdLATLVLEEDGTVVDtEEFFQSLEDNTEFMLLEAKQKWTQ 117
gi 134085781  33 PARPFRVSNHDRSSRRGVMASSLQELLSKTLDALVVasqLVTLVLEEDGTVVDtEEFFQTLGDNTHLMVLEQGQKWTP 110
gi 118086764   3 AGRPFRVSNASRSSRKGIVASSLQELISKILEAFLItagTVTLVLEEDGTVVDtEEFFQSLNDNTHFMVLEKGQKWTQ 80

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