Conserved Protein Domain Family
GH18_chitinase

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cd06548: GH18_chitinase 
Click on image for an interactive view with Cn3D
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
Statistics
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PSSM-Id: 119365
View PSSM: cd06548
Aligned: 71 rows
Threshold Bit Score: 286.834
Threshold Setting Gi: 189467212
Created: 4-Aug-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           #                            #                                               
1NH6_A       137 VGSYFVEWGVYGRnftvdk-ipaqnLTHLLYGFIPICggngindslkeiegsfqalqrscqgredfkvsihdpfaalqka 215
gi 11496137  123 NLAYFTNWGIYGRkyspld-vpycnLTHVLYAFADVNpdtgecfltdlwadeq-----------------------ihyt 178
gi 49650865    3 NVIYFCNWSIYARkhlpwe-ipcssTTHIIYAFANCDpltgevqlsdkwadeq----------------------ivfen 59
gi 47605402   75 SGVYYSNWSPYKPrfhfphdinlkqVSHIYYAFFKINsrtggientdswsdlemnlyks----------laiknselike 144
gi 39941244   49 SVAYVTNWSIYGAkflpeq-iavdsISHVQYAFADILangtvvssdawadtq------------------------kqfg 103
gi 116503901  64 NFAYFTNWGIYGAnfqptd-ivpdyITHILYSFADTDastgaikltdpysdeq-----------------------krfp 119
gi 49643188   68 VATYYSNWSPYNArnhkpadiptsqLTHVYYAFFVVDaksgavkssdsw------------------------------- 116
gi 169622499  40 SQVFYTNWAMYGRkhfvtd-lpadhLTKINYGFANVNnktgevflsdewsdv------------------------qfpy 94
gi 44981240   65 VGVYYSSWSPYKPrlhyprnidfqrVTHVYYAFFVVDektgkigsldkwsd--------------------------tkm 118
gi 31540489   58 SLGYYPNWGVYAKkyfvtd-ipadhFTHLSYAFANVNnktgevylsdpyadlq-----------------------yayp 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                     # #
1NH6_A       216 qkgvtawddpyKGNFGQLMALKQAHPd--LKILPSIGGWTLs--dPFFFMg-dKVKRDRFVGSVKEFlqtwkfFDGVDID 290
gi 11496137  179 gdswndtgnnlYGNFKQFLLLKKKNRa--LKLMLSVGGWTFg--pHFAPMaadAKKRAKFVSTAITIlen-dgLDGIDID 253
gi 49650865   60 dkwtddsekqlHGCFYQFNLLKRQHRq--LKLFLSIGGYSFa--gNFAEMakdETKRKRFAESAAQHvin-lgLDGIDLD 134
gi 47605402  145 ssnnsvqnilpLGCIGELFYLKNTCSdkkFKVIMSIGGWSDs--eNFKIIikdDKLLQNFVDSSVETmfr-lgFDGIDLD 221
gi 39941244  104 ngtqggnssdaHGLVEQLYKIKQANRn--VKMLLSIGGYTWs--pKFVPVaadAGKRAAFVSSAVALmgd-wgMDGLDVD 178
gi 116503901 120 gdtwtetgnnlYGCLKQLYLLKMKKRd--LKVLLSIGGWTYsqagHFNFVt-nPTARAKFISDAVQLied-ygFDGIDID 195
gi 49643188  117 sdfelplsvgvKGCIKELQKIKLESKh-eFKTILCLGGWSNr--eAYKKIaksEKKVKKFIETAVDCmfr-ygFDGIDLD 192
gi 169622499  95 pgdvatngsqlLGNFNQLYKLKQKNRn--LKVILSVGGWTWr--gNFKPAlatEAGRQKFCDSSLQLiad-lgLDGFDID 169
gi 44981240  119 pmnltgmprglNGAIGELNYLKTRPGt-dFKLMMAVGGWSNr--ePFHKIvrdEEKFNNFIDSAIDAmfe-ygFDGIDLD 194
gi 31540489  114 gddtkakgnnlYGNFKQLYKLKKENRy--LNTLLAIGGFTYs--aNFGPVlasKPLRETFAKSAVKLvad-lgLDGLDLD 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #                                                                              
1NH6_A       291 WLFPggkganpnlgspqDGETYVLLMKELRAMLdqlsve---------tgrkyELTSAISAGKDKIDKvaynVAQNSMDH 361
gi 11496137  254 WEYPsd---------stQAANFVLLLKELRAGLtahqakk-------netnpyLLSIAAPCGPDHYKVlqvaKMDQYLDF 317
gi 49650865  135 WEYAdt---------deKAQQYVELLRAVRLELdsvalkt------gldrhtfGLSIAAPGSVWYAKHlkiaEMDQFLSF 199
gi 47605402  222 WEFPgnn--------esEPRGYLKLVRMLRLKLnslesqif----gkrtedhfQLSIAAPAFKDKLFYlpitEIDQYVDY 289
gi 39941244  179 WEYPdt---------aeTNKNCVLLLQELRRGLddysqqh------tgsqykfSLSMPAPAGPTHYAAfdfkAMDASLDF 243
gi 116503901 196 YEYPst---------peQGQGLADLVTSLRTALtqlasrk-------gesnpyLITAAVGAGPAGYSNlkvaQMDRAMDY 259
gi 49643188  193 WEFPeed--------snEPIVYLEMMRGIREGMdqlerqifgspaeekdhphfQLSVATPAFAEKLNIlpisEMSKYVDI 264
gi 169622499 170 WEYAed---------atDAANFLDTVMRCRKAYdeyaaan-------ahgyhfDLGISAPAGPSRYSVlrmkEMDQYVDN 233
gi 44981240  195 WEFPkdd--------gyEPQMYLEMCSRLRHKMdeledniwg--pggtteprfHLSMAAPAFPQTLGIfpveEMNKYLSM 264
gi 31540489  189 YEYVan---------skEAEEIVDLLRLLREGLdklnrds-------katapfLLTFASPAGEQRYKVlnfpEMSKYVDL 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           # ##                                                                      #  
1NH6_A       362 IFLMSYDFYGafdlknLGHQTALNapawkp------------------dtaytTVNGVNALLAqGVKPGKIVVGTAMYGR 423
gi 11496137  318 WNLMAYDFAGsws-alTGHQANLWnikg---------------------appsADDSINYYIGqGVVSHKLVLGIPLYGR 375
gi 49650865  200 WNIMAYDFAGsws-pqSGHQSNLYgge------------------------isVDQIMNYYVQnGVASEKLILGMPIYGR 254
gi 47605402  290 WNMMTYDYYGsws-etTGYHSNLFsete----------------------lngNFAMHYMIDRfGVNSRKLVLGMAAYGR 346
gi 39941244  244 WSIMAFDFAGswd-ntTGHQANVYpgpdl-------------------ttkasIDVAVSDYVKaGVAPGKINLGLPLYGR 303
gi 116503901 260 WNLMAYDYAGswl-twADNQANFYggar---------------------tgysTDAALKWYISqGATKSKINVGMPLYGR 317
gi 49643188  265 WNMMCYDFHGews-dvTGYHSNLYlqghshrrsls--------nrisnsslssDTAVKLMTDRhNISSRRIALGMAAYGR 335
gi 169622499 234 WNLMAFDYQGggfsnfTGHQSNVYasktnpkttdgw------dsvlgkfmpfnTKEAIDYYKAnVASPCKIVLGMPLYGR 307
gi 44981240  265 WNMMTYDYHGaws-erTGYHSNLYnatnspykshldkrryedmgidnfdelnaHDAILMMTEQfKVSPRKIALGMAAYGR 343
gi 31540489  253 YNFMAVDYAGpsfskkTGYLDNLYadkknpd----------------atpfntASGIHYYLHEgKVPGSKIVVQNPLYGS 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1NH6_A       424 GWTGvngyqnnipftgtatgpvkg--------twengivdyrqiasqfmsgeWQYTYDATAEAPYVFKpstgDLITFDDA 495
gi 11496137  376 GFENtdgpqqpyrgtgqgt------------------weagnwdykflpvkgAKEMINTKIAASWSYDsakrEFISYDTP 437
gi 49650865  255 SFAGtdglnkpytsvgegtqee-------------gswergvwdykklprpgFEAHFDDQCKASYLYNkdtkTLVTYDDV 321
gi 47605402  347 SFHIkdnkfepfnqntvlinkifkgvgkptkeidkadgkegiwpyknlpkigTIEQYDPKYVSAYCFDeknsIFISYDNT 426
gi 39941244  304 SFDKttglgkgytastagsl----------------egqagiwiykdlpragATVLYDDVAKASYTMDnstgQLISYDDL 367
gi 116503901 318 AFQNtdglgapysgigpgt------------------iepgiysykalplagGQVYENKTDMTSYSYDpvkrELVSYDTP 379
gi 49643188  336 GFTNvetnddnylgkkyhgvgg------------gsegepgiwlynqlpidgSKEQFDSNAVSAYCFDpksrTFVGYDNV 403
gi 169622499 308 SFGNvvdlskdqrglgqkfngsg-----------egtwepgtldykflplngSKVYQDKETLSSWSWDpvkkEVVSFDTP 376
gi 44981240  344 GFTNvrgdgeqligqkysgvgg------------gsegepgmwlynqlplahGPEKFDNVWVSAYSYDpntkTLVVYDNV 411
gi 31540489  317 AFNGtngigqsfkdaglqgsl--------------gtagtwfvkdlppkgfnLEVTNNKAVGGSYSYDkaqkYLIAHDTP 382
                        410       420
                 ....*....|....*....|....*.
Feature 1                            #     
1NH6_A       496 RSVQAKGKYVLDKQLGGLFSWEIDAD 521
gi 11496137  438 QNVLLKCQYIRNKRLRGAMFWELSGD 463
gi 49650865  322 NVVKLKSEYVRQKNLGGGMWWESSAD 347
gi 47605402  427 KSVKTKAEYVTHNNLGGGFWWESCGE 452
gi 39941244  368 KSVQFKSDYVKQKQIGGVMFWESSQD 393
gi 116503901 380 NIVRMKAIYVEKNGLGGTMFWELSTD 405
gi 49643188  404 QSMDIKGKYIKKKNLNGGFWWESCGD 429
gi 169622499 377 KTAVWKTDFLKSEGLGGAWWWDSSSD 402
gi 44981240  412 DSMKIKKEYVKDKKLAGAFLWESCGD 437
gi 31540489  383 VTVRQKVDYVKKTKLAGTSFWEISQD 408

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