Conserved Protein Domain Family
ASCH_ASC-1_like

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cd06554: ASCH_ASC-1_like 
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ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation. The domain has been named after the ASC-1 protein, the activating signal cointegrator 1 or thyroid hormone receptor interactor protein 4 (TRIP4). ASC-1 is conserved in many eukaryotes and has been suggested to participate in a protein complex that interacts with RNA. It has been shown that ASC-1 mediates the interaction between various transciption factors and the basal transcriptional machinery.
Statistics
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PSSM-Id: 119346
View PSSM: cd06554
Aligned: 31 rows
Threshold Bit Score: 81.9935
Threshold Setting Gi: 168724474
Created: 12-Aug-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WK2_A         5 KLGLIVREPYASLIVDGRKVWEIRRRk---TRHRGPLGIVSg--gRLIGQADLVGVEGPFsv--------eELLAHQek- 70
gi 3258366     1 MKGLIIKQPYANWIVEGKKVWEIRKTp---TKIRGRVIIISe--kKAVGSVEIVDVLGPFtp--------eELANHEnkh 67
gi 168724474   1 MKCLIVKEKWADLILSGEKTLELRSRn---TNVRGTIGIIKsgtgLICGTVDILSSYEITdee------yiELKNKHk-- 69
gi 187939691   1 MKALSIRQPWAWLVANGHKDIENRDWa---TNFRGRFLVHAs---KGMTREEYEEARDYAarngvtipaphELERGGivg 74
gi 161529026   1 MKCLSVSQPFAELIILGKKTIELRKWn---TNYRGELLIHSp---LKIRKEDAKRLKIDK-----------KFVTGAivg 63
gi 160885914   1 MKAITIKQPWASLIVHGIKDIENRTWacpwKYIGHRVLIHAs--gKPVEMRNPNSVFTKAqw--------dSLPIEFqrk 70
gi 194513529   1 MKALSIRQPWAWLVAAGHKDIENRTWp---TSYRGPLLIHAs---KGMTRAEYENAMRFAivagiaykelqCFDESArgg 74
gi 91772464   61 IRVLAIRQPWASLIIRGLKNIEVRSKn---TYVRGTIAIYAs--rSIIRKKDLKLVNENYdipi---eqldDLPTGMiig 132
gi 153890034  22 LPALAIRQPYAWLVINGIKDIENRSRr---THYRGKVLIHA----SLSEDLLFEDSLAELgir-----agiELPESYdig 89
gi 149173951  12 LPALGIRQPWAELILRGEKTIEIRSSq---TKIRGTIYVYAs--kKLATTPHAVKAASKAgid------vnTLPTGTlv- 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
1WK2_A        71 ------------------hLAEEAFLRAYAkd-----------epLYAWVLENAFRY 98
gi 3258366    68 -----------------laSYDFLKRYANGk-------------kLYAWVLANPEKY 94
gi 168724474  70 -------------------VPYSREQIKYKk--------------IFAWELHNPVKY 93
gi 187939691  75 k--------------asiiGCVYDSDSPWFf-------------gKYGFELSDARPL 104
gi 161529026  64 kveiy-------dvkkydsQKQVKSDQKFHfaskn------fhdrTYGFLLKNAKTF 107
gi 160885914  71 iicaegivnsaiigsveiiGCSINHPSKWAektddsk--gyyenpIYNWVLANPILF 125
gi 194513529  75 i---------------igiADLFDCVPPSRavspw------qiegSYGFALRNARPL 110
gi 91772464  133 tvnlvec--keyesdfhfkLDQRRHLNPEEsys----------knIKGWFLKSPRPI 177
gi 153890034  90 giv----------gvaeivGCERRHESDWKdp------------sSWGWVLANARPL 124
gi 149173951  80 -----------------gtVEIVDSFPATEkhaaaagvpaellagKYGWKLANPRRL 119
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