Conserved Protein Domain Family
KPHMT-like

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cd06557: KPHMT-like 
Click on image for an interactive view with Cn3D
Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a precursor to coenzyme A and is required for penicillin biosynthesis.
Statistics
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PSSM-Id: 119342
View PSSM: cd06557
Aligned: 180 rows
Threshold Bit Score: 284.697
Threshold Setting Gi: 85704649
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #                  # ###                                     # 
1OY0_A        23 THHLQRWKadgHKWAMLTAYDYSTARIFDEaGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGapHALVVADL 102
1M3U_A         6 ISLLQKYKqekKRFATITAYDYSFAKLFADeGLNVMLVGDSLGMTVQGHDSTLPVTVADIAYHTAAVRRGapNCLLLADL 85
gi 85704649    9 LKHLAEKVqkgERIVGMECHDTPSAMMAEElGMDLLCCGSPGPMGLMGHKSMATVDFEEQLYMLQGVLRGasSPFIICNM 88
gi 124265976  16 ITEIRDSKksgEKMVYTSVPDYTSAKWAELaGVDVAVVGDSLAMVAHGHSSTVPATMDMMVMHAQAVRRGapRTFTLGCM 95
gi 148980691   5 PSSFVEMKg-kQRIPMLTAYTFPVAASIESaGIPIILVGDTVGMVEMGFSSTRDVTIEHMEYHVGAVRRGapNTHIIGDL 83
gi 150389007   7 ILDLMKMKkaeEQVAWVTAYDFPTASFAEQaGMEMILVGDSLGMVVLGYQGTIPVTMEDCISHCQAVRRGapNTWVIGDM 86
gi 158521098   4 LSVFRDYKkqgRKITMLTAYDYPTAVLEDRaGIDILLVGDSVGRNILGYASELEVTMEDMLHHVRAVARGakQAHVMGDM 83
gi 163708084  25 ITDIRNSKrtgEKMVYMSVPDYTSARWAEMaGVDVAVVGDSLAMVAHGHPSTIPATMDMMVLHAQAVRRGtpNTFVLGCM 104
gi 177676762   4 SARFFEMKrrgEPIAVLTAYDAPTARAEAEaGVDVILVGDSVGANVLGYASEREVTLADMRHHVAAARRGapDAVIIGDL 83
gi 182680199   7 AARFAEMKrrgEPIAMLTAYDAPMARAEAAaRVDILLVGDSVGTNMLGYASEQEVTLADMAHHTRAVRRGapDAFVISDL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    #                       #    #                      
1OY0_A       103 PFGSYeagptAALAAATRFLKdGGAHAVKLEGGerVAEQIACLTAAGIPVMAHIGFTPQSVNTLGgfrvqg-rgdaaEQT 181
1M3U_A        86 PFMAYat-peQAFENAATVMR-AGANMVKIEGGewLVETVQMLTERAVPVCGHLGLTPQSVNIFGgykvqgrgdeagDQL 163
gi 85704649   89 PNTTAsisieESVRNAAKVVK-LGADGVHIEPSlgTVPHIRAIVDAGIPVVGHFGVQGERAVMNSghspagrtageaAAI 167
gi 124265976  96 PYQSYnt-vdRALLNATRFMQdGGCDAVKPQGGrsQAHILKALVDSGIPTASHIGLTPHTIAMFGgfkiqgrtaeaaMKI 174
gi 148980691  84 PYLTDrs-peAALFNAKRLMQ-AGADSIKLEGA--KLDVIAHLVANNIPVVGHTGLTPQTATNFKkvgqs---aedaQTV 156
gi 150389007  87 PFGSYqvsdeDAVRNAVRFMKeADVDCIKLEGGdrVKSRIRAITDAGIPVMGHIGLTPQSSGQLGgfkaqgrrvdnaRVL 166
gi 158521098  84 PYRSCdt-paLALENARRMMD-AGAHSVKIEGEqdMVDRIKYVVDAGVPVCAHIGYTPQTSGKAAvqgkd---idraKAL 158
gi 163708084 105 PYQSYnt-veRALTNATRFMQdALCDAVKPQGGrsQAHILKALVDAGIPTASHIGLTPHTIATFGgfkiqgrtaeaaMKI 183
gi 177676762  84 PFETYgg-peIAIASARALIG-AGADIVKFEGA--DVAVLKALTDAGIEVCCHLGLEPQTHADKRlkgrs---aqdaARL 156
gi 182680199  87 PVATYet-ptEAVANARVLAE-AGADMVKFEGC--RPAIVEALVGAGFAVCGHLGLEPQHHAEKRlkgkq---ageaHQL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #                              # #                             
1OY0_A       182 IADAIAVAEAGAFAVVMEMVPAELATQITGKltIPTVGIGAGpnCDGQVLVWQDMAGfsgaktarFVKRYAdvGGELRRA 261
1M3U_A       164 LSDALALEAAGAQLLVLECVPVELAKRITEAlaIPVIGIGAGnvTDGQILVMHDAFGitgghipkFAKNFLaeTGDIRAA 243
gi 85704649  168 IELVRASIEAGIFAALFEHTSVELTKWCYENlpVAVASLGSGpyAHGIFHVSSDIIGcsvfpippKRELFGdvWGEMQKA 247
gi 124265976 175 LEDAFAIQDAGCFMLEFEAVPAKIATLISKQleIPTIGIGAGagCDGQILLSYDLLGvftdfkpkFTKRYAnlTEVAVQG 254
gi 148980691 157 SEEAKAIQEAGAFMLVLEHIPSSLGESITKEisIPTIGIGAGadCDGQVLVINDALGlgnr-wppFSKQYAhcSQTIFDA 235
gi 150389007 167 IQDALVVQEAGAFSLLVEAVPPEVTKFIADKldIPVYSIGAGp-CDGQLVISGDMLGkfqaftpkFIKKYAnvAEVETNA 245
gi 158521098 159 IDAALQLEKAGADMVVFELIPELLAKEITNLlsIPTIGIGAGrfCDGQVQVYCDILGlsar-vfrHAKAYDtlGQRYEDA 237
gi 163708084 184 LEDALAIEDAGCFMLEFEAVPAPIAKLISEQlsIPTIGIGAGagCDGQILLAYDLLGvfidfkpkFTKRYAnlTEVAVTG 263
gi 177676762 157 LADAIRLDEAGMKMLVLEMIPEEVAAEITRAvrAPTIGIGAGrrTDGQVLVITDVLGfgar-nfrHNRRYQevGRLMRET 235
gi 182680199 160 VEAALTMEKAGIAMLVLELIPEEVAEIVTQRlkVPTIGIGAGraTDGQVLVICDVLGytka-afrHNKRYAevGETMEAA 238
                        250
                 ....*....|....
Feature 1                      
1OY0_A       262 AMQYAQEVAGGVFP 275
1M3U_A       244 VRQYMAEVESGVYP 257
gi 85704649  248 YSAYYNAAKSGQFP 261
gi 124265976 255 LKAYVDEVKTGRFP 268
gi 148980691 236 ANEFATQVKTNVFP 249
gi 150389007 246 FKEYVAEVKAGQFP 259
gi 158521098 238 FAAYAREVTGGTFP 251
gi 163708084 264 IRSYVEEVKTGAFP 277
gi 177676762 236 AAAYVRDVHDGGFP 249
gi 182680199 239 ARAYVGDVHSKAFP 252

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