1J1V,2HCB,1L8Q


Conserved Protein Domain Family
Bac_DnaA_C
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cd06571: Bac_DnaA_C 
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C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple copies of DnaA, which is an ATPase, bind to 9-mers at the origin and form an initial complex in which the DNA strands are being separated in an ATP-dependent step.
Links
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Statistics
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PSSM-Id: 119330
Aligned: 196 rows
Threshold Bit Score: 56.754
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DnaA
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:DnaA box-binding interface [nucleic acid binding site]
Evidence:
  • Structure:1J1V_A: The c-terminal domain of Escherichia coli DnaA binds to the 9mer DnaA box of a DnaA box DNA, contacts at 3.5 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                               #       ##      #     ###        #####  #  ##            
1J1V_A         3 IDNIQKTVAEYYKIKVADLLSKRRsrsvARPRQXAXALAKELtNHSLPEIGDAFGgRDHTTVLHACRKIEQLrees-hdi 81  Escherichia coli
2HCB_A       229 LMQIVEFVANYYAVKVEDILSDKRnkrtSEARKIAMYLCRKVcSASLIEIARAFKrKDHTTVIHAIRSVEEEkkkd-rkf 307 Aquifex aeolicus
1L8Q_A       230 LXQIVEFVANYYAVKVEDILSDKRnkrtSEARKIAXYLCRKVcSASLIEIARAFKrKDHTTVIHAIRSVEEEkkkd-rkf 308 Aquifex aeolicus
ABC87040     198 VERIQEVVADYFMQTVDDMKSSRRqsdiVGARHVAIYLTRTMtDMSLPQIGKAFGnRDHSSISHAFTKIEEQiekd-trm 276 Leuconostoc fru...
ZP_02177524  314 LEKIKLYTAVHFGIEPEELTGSKRskkvNRARHIAFYLCRKLtDASLIEIARAFNrNDHSTVIYGIRKIEEErrkd-rkl 392 Hydrogenivirga ...
ZP_01368885  231 PQNIIQKVAELTGVAAAAIYSTTRtpevRQARQLAIYGIRSLsRLSYPEIGASLN-KSHSSIMKSYQQFQEAvqkn-pel 308 Desulfitobacter...
YP_001232647 232 ADKVLSVVADHYGVTVETVAGPER----NDIRKVCIYLLKKHtAVANSEIGGMLGgMSGFAVAKAHQLLVAGmake-aal 306 Geobacter urani...
YP_497976    136 IDDAVEAIARAMKVTVADIMGPDRakvfMQARQVAYWVLHQR-GQSTAQIGRRLN-RDHSSVINSLRRYETHatprmrlv 213 Novosphingobium...
YP_358051    251 LKELVQIVADKLEVGSEDIRSGDKrpkrVAARSILCFWAVKElGCSTMEIAGLLG-ITQSAVSRSVQRGQKLa------- 322 Pelobacter carb...
YP_498279    141 SNVALKKVADALRISEAEILSGSRfaetVDARSVVAEIMLRQ-GMSYPRVGRRLN-RDHSSIINLHRKFPHRas-----r 213 Novosphingobium...

Feature 1                   
1J1V_A        82 KEDFSNLIRTL 92  Escherichia coli
2HCB_A       308 KHLVGFLEKQA 318 Aquifex aeolicus
1L8Q_A       309 KHLVGFLEKQA 319 Aquifex aeolicus
ABC87040     277 KEMVQSLAEEI 287 Leuconostoc fructosum
ZP_02177524  393 NYIISFLEKHI 403 Hydrogenivirga sp. 128-5-R1-1
ZP_01368885  309 REMLESLVKYF 319 Desulfitobacterium hafniense DCB-2
YP_001232647 307 RKEVGRLEANL 317 Geobacter uraniireducens Rf4
YP_497976    214 AEWFAGAERRA 224 Novosphingobium aromaticivorans DSM 12444
YP_358051    323 REKGWRLAEWV 333 Pelobacter carbinolicus DSM 2380
YP_498279    214 RPILAKLVDQI 224 Novosphingobium aromaticivorans DSM 12444

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