Conserved Protein Domain Family
Bac_DnaA_C

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cd06571: Bac_DnaA_C 
Click on image for an interactive view with Cn3D
C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple copies of DnaA, which is an ATPase, bind to 9-mers at the origin and form an initial complex in which the DNA strands are being separated in an ATP-dependent step.
Statistics
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PSSM-Id: 119330
View PSSM: cd06571
Aligned: 196 rows
Threshold Bit Score: 56.754
Threshold Setting Gi: 77920236
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
DnaA
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:DnaA box-binding interface [nucleic acid binding site]
Evidence:
  • Structure:1J1V_A: The c-terminal domain of Escherichia coli DnaA binds to the 9mer DnaA box of a DnaA box DNA, contacts at 3.5 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                               #       ##      #     ###        #####  #  ##            
1J1V_A         3 IDNIQKTVAEYYKIKVADLLSKRRsrsvARPRQXAXALAKELtNHSLPEIGDAFGgRDHTTVLHACRKIEQLrees-hdi 81
2HCB_A       229 LMQIVEFVANYYAVKVEDILSDKRnkrtSEARKIAMYLCRKVcSASLIEIARAFKrKDHTTVIHAIRSVEEEkkkd-rkf 307
1L8Q_A       230 LXQIVEFVANYYAVKVEDILSDKRnkrtSEARKIAXYLCRKVcSASLIEIARAFKrKDHTTVIHAIRSVEEEkkkd-rkf 308
gi 86169601  198 VERIQEVVADYFMQTVDDMKSSRRqsdiVGARHVAIYLTRTMtDMSLPQIGKAFGnRDHSSISHAFTKIEEQiekd-trm 276
gi 163782527 314 LEKIKLYTAVHFGIEPEELTGSKRskkvNRARHIAFYLCRKLtDASLIEIARAFNrNDHSTVIYGIRKIEEErrkd-rkl 392
gi 109644965 231 PQNIIQKVAELTGVAAAAIYSTTRtpevRQARQLAIYGIRSLsRLSYPEIGASLN-KSHSSIMKSYQQFQEAvqkn-pel 308
gi 148265941 232 ADKVLSVVADHYGVTVETVAGPER----NDIRKVCIYLLKKHtAVANSEIGGMLGgMSGFAVAKAHQLLVAGmake-aal 306
gi 87200719  136 IDDAVEAIARAMKVTVADIMGPDRakvfMQARQVAYWVLHQR-GQSTAQIGRRLN-RDHSSVINSLRRYETHatprmrlv 213
gi 77920236  251 LKELVQIVADKLEVGSEDIRSGDKrpkrVAARSILCFWAVKElGCSTMEIAGLLG-ITQSAVSRSVQRGQKLa------- 322
gi 87201022  141 SNVALKKVADALRISEAEILSGSRfaetVDARSVVAEIMLRQ-GMSYPRVGRRLN-RDHSSIINLHRKFPHRas-----r 213
                         90
                 ....*....|.
Feature 1                   
1J1V_A        82 KEDFSNLIRTL 92
2HCB_A       308 KHLVGFLEKQA 318
1L8Q_A       309 KHLVGFLEKQA 319
gi 86169601  277 KEMVQSLAEEI 287
gi 163782527 393 NYIISFLEKHI 403
gi 109644965 309 REMLESLVKYF 319
gi 148265941 307 RKEVGRLEANL 317
gi 87200719  214 AEWFAGAERRA 224
gi 77920236  323 REKGWRLAEWV 333
gi 87201022  214 RPILAKLVDQI 224

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