Conserved Protein Domain Family
PASTA_Pbp2x-like_2

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cd06575: PASTA_Pbp2x-like_2 
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PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Statistics
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PSSM-Id: 119326
View PSSM: cd06575
Aligned: 114 rows
Threshold Bit Score: 49.7581
Threshold Setting Gi: 168182385
Created: 3-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
1RP5_A       647 EVPDMYGWTKETAETFAKwlNIELEFEGSGs-tVQKQDVRANTAIkd-iKKIKLTLG 701
gi 150016454 684 VMPDVRGYSKEDANTLLKklGIVPAFEGSGa--VSEQDISQGEVItk-gTTVKLTLS 737
gi 81530048  671 IVPNLTGYSKKEAEETLKslGLDFKISGDGv--VESQSIDAGKQVnk-gTVLTLKLE 724
gi 168186151 676 VVPNLKGYSKEKAAELLKnlGIQVKFIGDGv--VLDQSIAPGKAVnrgkAIVVLTLK 730
gi 89210842  638 TVPDLTGMTVNEALDLLFelGLKMDYNGSKeslIITQDIEPGSRVpg-gTTIIVEVS 693
gi 81766861  673 VVPDFRKLNKEEAEEILKylGLKGEFEGEGe--IKEQSISAGEIIks-gDKIKFKLE 726
gi 81767912  673 IIPDFKNYSKESAEKLLNqlGLIGEFVGEGp-sVTKQSISPDEVVng-nSKITLTLG 727
gi 182418002 695 SMPDIKGYSKESAYELLSklGITATFEGEGa--ARDQSISSGEIVpk-gTSVKITLE 748
gi 81766873  684 IVPDFNGLSMEKAKEILNkiGLKGTFAGEGv--IKEQSVVQGDVVks-gTSIEFKLD 737
gi 160944901 733 EVPDVTGKSPDFARQMLSaaGLNCVVEGSGt--VQAQSAEPGSSVqr-gTIITLTCG 786
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