Conserved Protein Domain Family
PASTA_Pbp2x-like_1

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cd06576: PASTA_Pbp2x-like_1 
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PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are connected to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Statistics
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PSSM-Id: 119327
View PSSM: cd06576
Aligned: 70 rows
Threshold Bit Score: 49.4298
Threshold Setting Gi: 81631121
Created: 3-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
1RP5_A       589 PMPSVKDISPGDLAEELRRnlVQPIVVGTGTkIKNSSAEEGKNLApNQQVLILSD 643
gi 116494760 603 TIPAVTNAALTTAQDSLKQanFDVATVGTGNkVVQQLPTSGTKALhGSRVLLLTN 657
gi 81403169  603 KVPVLAGKTIDEAKKIVKDkgLELIIVGNGKkIVQQLPQANAEIMqGQKVILMTD 657
gi 81428359  579 KVASVLSQSTKDAQKKLEAqnLKTTLVGSGNlVVQQLPKAGSVILpNQRVLLMTN 633
gi 89210842  572 VVPDIIGKKAIKAEEVLRKagLDVKLVGMKEkVLRQVPLPGARVKeGTTVIIFTE 626
gi 169188378 585 SIPELAKLKVTEAKSQLRSrgLNAEIVGSGKtIIQQIPASGALVHpGQKVYLITE 639
gi 27262270  589 AVPQVTGIGVDDAEDRLLHvgLGVATEGFGTrVVNQLPQPGEKVTpQTTVVLYLA 643
gi 81481323  559 MVPDVRNMKLYEAERIILEnkLDFILQGNGDtVFDQVPKPGALVNeNTKIILYLN 613
gi 109645971 592 TVPSVLGLTLAEAEKSLRQagFTVLTEGSGTvVQDQIPHGDSKVEeGSSVLLYLG 646
gi 163790541 609 KMPKVTGIAKEEALKSLEDtqLNVTVVGNGDtIVQQLPLPEETTIeNQRVVLMTN 663
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