1JR2,3D8N


Conserved Protein Domain Family
HemD

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cd06578: HemD 
Click on image for an interactive view with Cn3D
Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in the human uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria, a recessive inborn error of metabolism also known as Gunther disease.
Statistics
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PSSM-Id: 119440
View PSSM: cd06578
Aligned: 415 rows
Threshold Bit Score: 79.6587
Threshold Setting Gi: 81345157
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3D8N; Thermus thermophilus Uroporphyrinogen III synthase with bound product uroporphyrinogen III, contacts defined at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            #                                                                    ###    
1JR2_A        24 VLLLKdakedd---cgqdpYIRELGLYGLEATLIPvlsfef--------lslpsFSEKLshp--edYGGLIFTSPRAVEA 90
3D8N_A        36 IAYAGlrr--------keeFKALAEKLGFTPLLFPvqatekv-----pvpeyrdQVRELaq----gVDLFLATTGVGVRD 98
gi 149928341   5 LVVCKpklpdqyltqrvdlKRQLDQMHSGHVMYFPvfelvpd------laslltIRPWLetttdkpNHLIVFVSPSVLEI 78
gi 15838399   61 LLSLRpann-------haaLRRAVARYGGGLIALSpwrlkrl-----dspetrsALASAl-----tASTLVFTSPEAVRA 123
gi 21229676   21 LLSLRpsge-------hapLRRAVARHGGQLLAVSpwrlqin-----dtlqardALRQAl-----gAPIVVFTSPAAVHA 83
gi 194363909  22 FISLRpqgq-------haaLRRAVAGLDGHLLALSpwrlqrl-----hgtpvvrQLQRAl-----nCDRVVFTSPAAVAA 84
gi 148654059   3 FINTRpier-------aqpLTQAMQDKGLTVLELPlleltaieigqreqqyqqhFYQQPd-----qYQALVVVSPTAARM 70
gi 71064671   27 VINTRpver-------aapLTRHLQAAGMSVIDMPmltlqprs---ttdndmilMRQWLag----eYQALVIVSPTAAAS 92
gi 193076129   3 FINTRpdsr-------aaeLTHALQKKGFQVESLPllelvaqp----fseslsqLYQQLt-----gAQAIVVVSPTAVDV 66
gi 45644675    3 IIDTRs-------------NIAFSNHKKGSIKNIPlfelk----------sfeyALPSKd------FTDIIFQSIPSVEF 53
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   #                                    
1JR2_A        91 AElcleqnnktev-----------werslkekwnaKSVYVVGnATASLVSKIGLdtege---------tcgnAEKLAEYi 150
3D8N_A        99 LLeagkalgl-----------------dlegplakAFRLARGaKAARALKEAGLpphav---------gdgtSKSLLPLl 152
gi 149928341  79 AVtnlgq------------------------wpanVYCGVMGrQSAKLAIDLGIpkdniiaptgendhetedSDGLARLl 134
gi 15838399  124 AHalqtl-----------------------raspgQVWLCVGaSTARMLQQCGItrvlh--------ptqmnSEGLLTLl 172
gi 21229676   84 AHrllpl-----------------------qrpgpAQWASVGeGTARALQACGIdavvr--------parmdSEGLLALp 132
gi 194363909  85 AAsllpl-----------------------adaqrSPWLTVGeGTARALRAQGVhevha--------pqrmdSEGLLALp 133
gi 148654059  71 GLaacpi-----------------------gfvprCAVIAVGhATAEVLRVAGWqvhcp---------veysNEGMMLMp 118
gi 71064671   93 GLaiwqllererqangatdkavegiedslgvlvapSHLIAVGeATAAVLNEVKLpfasyqv----lqpaianNEGMLSMp 168
gi 193076129  67 GMqyltqsgl------------------kidelkyIQWIAVGqATANRLHDYGIeahvp---------evetSEGMLNLp 119
gi 45644675   54 FKekdh--------------------------linKDIYTMGpSTKNFLLQKGFdsicp---------aipgSKELIKLl 98
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #                       # #                                    
1JR2_A       151 csr---essaLPLLFPCGnlkreiLPKALKdkGIAMESITVYQTVAhp------giQGNLNSYYsqqg------------ 209
3D8N_A       153 pq------grGVAALQLYgkplplLENALAerGYRVLPLMPYRHLPdp------egILRLEEAVlrge------------ 208
gi 149928341 135 athf--eagsCRVMVCKGprgrveFPKKLVemQHDVTVLECYDRKVieqs--dtqcEALFARTSea-------------- 196
gi 15838399  173 aqqp--ptevGLITAPGGrd---lLQQKLLenGIRLHRANVYERQPlrlr---tatLDVLQRNAtr-------------- 230
gi 21229676  133 vfda-plhavGLITAPGGrg---tLSPALEqrGAQILRADVYQRVAlrlr---astLHALESALpr-------------- 191
gi 194363909 134 vla---dvrgRRIGLVTApggrglIAAQLQaaGASIERADVYQRRPlrl-----spRTLARLAHsay------------- 192
gi 148654059 119 qlnrlgvgnrILVWRGRGgr--rvLVNFLQenGVGVDAIAWYQRQCpp------qaEHDFKQLLpqlglsevaklpdain 190
gi 71064671  169 eidslqagdkLLVWRGLGgr--rlLVDTLQarGVHIDSIAWYERKIpvda--maqyQQWLQDFDsqnaiggit------- 237
gi 193076129 120 llhrmqksgsVAFWRGEGgr--qfMMETLQqqGIQILNFVLYRRQCpqasystfkhLTQNSNYNldk------------- 184
gi 45644675   99 pn-----lnnNKYLIVKGddglsdIFDYLYknKNNVEEISCYKRVKfk-------sYDDVKESFlka------------- 153
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                #####                                                   
1JR2_A       210 -----------------vpasITFFSPSGLTYSLKhiqels---------------gdnidQIKFAAIGPTTARALAa-- 255
3D8N_A       209 ------------------vdaLAFVAAIQVEFLFEgakdpka------------lrealntRVKALAVGRVTADALRe-- 256
gi 149928341 197 --------------------vLWITSSETIEALDSqlarkses-----------rlktlkeTATVLTTHPRITAKCRe-- 243
gi 15838399  231 -------------------smLALSSAEALALLLPqwpdnl---------------rrilyQRPVIATSKRLEDLACa-- 274
gi 21229676  192 -------------------svMALSSSEALTLIVQqlppsl---------------atalkTRPVVASSDRMLEAARa-- 235
gi 194363909 193 ------------------pwvLAVSSGEALQHFWRqlphal--------------qqrlqaHASVVVASDRLREQAQa-- 238
gi 148654059 191 lnslhispldnpdanskhkplVLISSGEAFTNWRLlmasideisd-------kavpnyqlnDFNYLTFGKRLTDTLNq-- 261
gi 71064671  238 -------------isqqakpiVIVSSGTAFEHWQSivqatktlnlaaenqamsvnvtlelsDFAYVVLGERLANMVAe-- 302
gi 193076129 185 -------------------wlVLITSEASWKYWLElclkn-----------------kaqpDCVYLVLGPRLFQLVKdyr 228
gi 45644675  154 -------------------daVIFSSTFGAQIFFEeiys-------------------sdvKAKLFGISNRIINYISd-- 193
                        330       340
                 ....*....|....*....|....*..
Feature 1                                   
1JR2_A       256 ----qGLPVSCTAEsp--tpQALATGI 276
3D8N_A       257 ----wGVKPFYVDEte--rlGSLLQGF 277
gi 149928341 244 ----lGYAHVVQIAtgiqsvNSWLKSN 266
gi 15838399  275 ----rGFISVYRTTgp--lpRQLAATA 295
gi 21229676  236 ----aGFVQVHRSEgp--lpAQLAAAA 256
gi 194363909 239 ----lGLQRISRSAgp--agAQLVSAA 259
gi 148654059 262 ----lQLNCVRIENld---tSEVWRGV 281
gi 71064671  303 ----qHLSYWRVEDla---pETILAAI 322
gi 193076129 229 dqqqaHFHIIQLENls---pSGMIHHI 252
gi 45644675  194 ----iGYESKFIDYf----aNDIAESI 212

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