Conserved Protein Domain Family
TM_PBP1_transp_AraH_like

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cd06579: TM_PBP1_transp_AraH_like 
Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group also contains E. coli RbsC, AlsC, and MglC, which are TMs of other monosaccharide transporters, the ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also be involved in low affinity ribose transport. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Proteins in this subgroup have a single TM which homodimerizes to generate the transmembrane pore.
Statistics
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PSSM-Id: 119321
View PSSM: cd06579
Aligned: 305 rows
Threshold Bit Score: 119.821
Threshold Setting Gi: 115358081
Created: 9-Sep-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
TM-ABC
Feature 1:TM-ABC transporter signature motif
Evidence:
  • Comment:a signature motif (the EAA motif) conserved in all TMs of ABC transporters.
  • Comment:a conserved hydrophilic segment, part of a loop which interacts with the cytoplasmic ATPase.
  • Citation:PMID 7934906

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 84027833   53 TSVNAIMAVGMTLVILTSGIDLSVGSLLALTGAVaasiv-gievnALVAVAAALALGAAIGAVTGvIVAKGRVQAFIATL 131
gi 111025222  73 EAVLILVALGAMLPLIVGQYDLSVGANMGMASIAvamatselgfsTGAGIAVAIVLSTLLGFVNGfLVAKIGISSFVATL 152
gi 119714866  88 QAVIGVISLGLLLPLLCQEFDLSVGNIAGLAAIVvaayv-ssegnVLAAVVLALTIGLAIGAVNAlIVTRLHVNGVIATL 166
gi 111221950  49 QSILGILAIATVIPLVAGQIDLSVGPNAGLTSVLcaglmsksgwpLFPAILAAIVVGLVIGTINAiLVASVGINSIIATL 128
gi 119714928  73 QATAAMLAMGVTLVLIIGEFDLSVAAVMGLSASLiaylttehgvsVPLACLVALALAAIVGLVNAaLVVGAGLNSFIVTL 152
gi 89068576   63 AAFLTLAAQGQALVIMARGIDLSVPAIVTLSSTVllavsggtegnSLLAILVALAAAMLVGAVNGfFIAVLRMNALIVTL 142
gi 114764372  64 AAILAITAVGMTVVIQQRGLDMSLPGTMTIAGLLfakig-fmtgsTLLAVPLTLLIALGIGIVNGlLVAKVNITPIVVTL 142
gi 119714368  65 QAVPLVLTLCLVLPLVCGDYDMSVASVATLTAMVigilnvnhgwsIGAAILAGLLAALLAGLVNGaVIVIFGVDSLIVTL 144
gi 111027001  75 QATVLLLAVAITIPLRSGDMDLSVAAVMVMCATVvgaly-sngvsALLSCVIAVGVGLVIGVLNAvLIVVAGLESIIVTL 153
gi 198267074  47 EAVLVIVTLGLIIPLTAGDFDLSIAQVLTLVSMStalmdarmdvpLLIVIPIALAIGALIGFINGaITLYFRVNSLIVTL 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                   #####
gi 84027833  132 VMMLLLRGVTMVYTNGspvntgftenadlfgwfgigrplgvptpVWIMGIVFLAAWYMLHHTRLGRYIYALGGNEAATRL 211
gi 111025222 153 AVSSLLSGIVIWSTDGtvivdnipsaltd---igrssilyipipFLLVIVIALVMGYVLRMTPTGRYLYAVGGSSEASRL 229
gi 119714866 167 GMSTILGGIVLQRTGGlapasdipqsltn---fgtglvagvpiiFITLLVIAGITYFVLNHTSLGRQIYAVGSNMEAAKL 243
gi 111221950 129 GMSSVIGAAVLAYSGGvsittgvspgllr---lgpgkwlsvptlFYFLLGIALVAWYLLEKTPTGKNLYAIGSNPRAALL 205
gi 119714928 153 AVGTLVQGLAIGVAGSvtigglptslty----pfqsrfldvqaaFFFMLAVAFVLYLVVGRMPIGRSMFFTGNARAAAEL 228
gi 89068576  143 AVGAIVTGLTLSFRQAlpaeanvpaalad---fgggrtlgisnpFWIALVVTVLATLVLRKTVIGRKFEAVGANPAAARA 219
gi 114764372 143 ATNAILMGAVRAVSGGspmtapaelaef-----shsklfgvpmtLVLALLFILVISVVTKRSIAGRRFVAVGQNPAAATA 217
gi 119714368 145 GTGTVIQGLVLWISDSttvsgistslvdl---vigyklfsvpaaFYYGLALCVVLWYLLQHTALGMRMLFIGRGRDVARL 221
gi 111027001 154 GMYTLVAGLTSFVSGGnlvttipkslkd----fattpfltlpaiVWIGWLVALVVWFVFEFTPMGRYLLFVGGNRAAATL 229
gi 198267074 127 GVGTFLHGVTLWIGNSqtisgvspmlmew---viiqrvfgipiaFYYAMMLAVLIWYMLGYTAFGQQLLFTGRGREVGRL 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ##############                                                                  
gi 84027833  212 SGINVNKIKIIVYSLCGLLASLAGIIEVARLSsaqpTAGTGyELDAIAAVVLGGTsLAGGKGRIVGTLIGALILGFLNNG 291
gi 111025222 230 SGLSVDRLTITTFAASGFLCGIGGVLLVSKLGsanpTTGPEfLLPAFAACFLGATsIRPGTFNVTGTILAVLVLAVGSTG 309
gi 119714866 244 VGLRTDGLRAVTFAAGGLLCGLGGLLYVSRAGgaspNVGMTfTLPAFAAAFLSAAsVRPGRFNVWGTIIAVYFLAVLNNG 323
gi 111221950 206 VGIGVSRQTFGSLVLAGGIAGGAGVLLVAAVGagspQLGSNyTLPAIAAAFLGATsIQPGRYNVWGTITAVFFLAISVNG 285
gi 119714928 229 AGVRTARVRVGVMMTAGLLAGAAGVMFVGQTGaaspSIADPfLLPAYAAGFLGATaFTPGRFNVWGSVWAVYLLAVGTTG 308
gi 89068576  220 AGIETMRFQAGAYISAALLYGIMAVLISGFIRnptlEVGAPyLLAPIAAAVLGATsINGGIGSMIAILGAALFLTQLGQQ 299
gi 114764372 218 AGIPILRYQVATYAVAALCFAVAGMLFTGFIGsasqTAGIDyLLPAIAAVVVGGTpFSGGRGSVIASGAAALFMALLGQM 297
gi 119714368 222 SGIAVPRVRMGALVASAGLAGVAGTLYAGTTGsadpSSGTSfLLPAFAAVFLGATtVIPGRFNAWGAFIAVYFLATGITG 301
gi 111027001 230 AGLRVSRIRITALIAAAVISAIAGVLFAGSIGsvdpSSGHSyLLAPATAAFLGTTmIHMGRFNIIGTLIGLYLLAFGITG 309
gi 198267074 204 TGVAVGRVRLTAFVLSGIMGAIAGILYTGTTGsanpSSGTFlLLPAFAAAFLGATcIKPGRFNPWGAVIAVYFLVTGING 283
                        250       260
                 ....*....|....*....|....*.
Feature 1                                  
gi 84027833  292 LNLLGvssyYQMIVKAvVILLAVLVD 317
gi 111025222 310 LQLIGvpfyIEPIFAGvVLLIAALVT 335
gi 119714866 324 LSLAGvdpyVNDYVNGgALIAGVALA 349
gi 111221950 286 LTLWGaapwVSELFDGaALIVGVGLG 311
gi 119714928 309 FQFLGldnwVINVFNGgVLVLAVGLS 334
gi 89068576  300 LRLFGletsYQMIIQGiAIAIGMWLS 325
gi 114764372 298 VLAFGaetsVQLLVQAgAIIVAVSVR 323
gi 119714368 302 LQLLGaesfVQQLFYGgALVIAVSLA 327
gi 111027001 310 LQLLGvqgwVSDVFNGaALIVAITFA 335
gi 198267074 284 LSVLGfrtfVQDLFYGgALVLALMVS 309

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