Conserved Protein Domain Family
TM_PBP1_transp_TpRbsC_like

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cd06580: TM_PBP1_transp_TpRbsC_like 
Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters, which are mainly involved in the uptake of branched-chain amino acids (AAs) or in the uptake of monosaccharides including ribose, galactose, and arabinose, and which generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction.
Statistics
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PSSM-Id: 119322
View PSSM: cd06580
Aligned: 160 rows
Threshold Bit Score: 85.1834
Threshold Setting Gi: 152966087
Created: 9-Sep-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
TM-ABC
Feature 1:TM-ABC transporter signature motif
Evidence:
  • Comment:a signature motif (the EAA motif) conserved in all TMs of ABC transporters.
  • Comment:a conserved hydrophilic segment, part of a loop which interacts with the cytoplasmic ATPase.
  • Citation:PMID 7934906

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 81344761   15 STPILITALGGLFSERSGVINIALEGLMMFGAFstatvtvl--cepytiaaPWIALGVGMAVAASVALFYAYLSVRLCSD 92
gi 86607808   68 LAPLVLCCCGLVFTFVAGLYNLGIEGQMVVGAIaatflvrleagwlppplaITLALLAGILGGAGWGLLAGILNVWGRVN 147
gi 163849393  60 AAPLLLCAVGLSITFAGGLYNLGVEGQMIMGAIaamvplrlw-pdvsppllWLLAALCGMAGGAFWAGLIGLLRRYAGVS 138
gi 81777224   21 AIPLLLAGLGEQMSEKAGVLNIGIEGMMLAGAYlgfvga-------fysgsLWLGFLTGAAGGVAVALIMALLCVCIGLN 93
gi 124026997  66 FVPIGLSAAGLALAYRAGFITIGSEGQVILGLTvthgllayvlwdapglagLVAALVLAAIVGGACGLLVGAMRAYLGTN 145
gi 118430861   9 LIPLSLAALGEAVLERTGRVNLGVDGLMAVGAAvgalag-------vetgsLLAGLAAGALAGGVGSLSYIILTDRLGVN 81
gi 124026996  14 AAIVAVAAYGELLMERAGMLNLGLEGLVYFSSAaaaaaa-------aatgsLSAGFAVGALAGIALILVYYVAAIVFRAN 86
gi 162148473  13 TTPILLAALGGAINRQGGTVNVGLDSFILAGALagevas-------avtgsSLGGVAGAAIAGGGTAALMAAVIRFARTD 85
gi 14600420   52 AAILVAAASGLVLSYRAGLITIGVEAQVTASAVaalyal------ayaglgLPGALTLAAIVSLAIGIVIAALRVYLDVN 125
gi 126465046  15 FLAYYLAALGHAIVEKSGVLNLAIDGVFVLSVStafata------vythnnIGAALIVSMIIALIFGGLMAFLVTKFPIS 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 81344761   93 QIIAGTAINLCATGMTVFFaqvifgqqgtqaysrglvktsygffsripvlgpmvfthtyptVYLGFVLVALAWYVLYRTP 172
gi 86607808  148 EIFAGLGLNFVAQGWVLYLifgpwkrpgvasmsgtevl-----dprlwlptwgrseaspvaLLLALLALALTVLVVGNTR 222
gi 163849393 139 EIFAGLGMNFLASGIAMYMvlgpwrrqtsaslsgtdll-----prelwwptidrlrlapaaPVIALLALAVVWWALTKTR 213
gi 81777224   94 QIVIGIALTLGLEGLTALLhhfqfsrsyprlpaaeatvi---pllsdipvvgpalfkhhliVYLAVALVFGMGYLYRRTQ 170
gi 124026997 146 ETLISLMLNYVVVAIVNYLvsgpwkagrftmtv---------------vlpekfwvsgataAAVAAAAIVVLDLVHRFTR 210
gi 118430861  82 MIVAGLLVFFAGIGLGDLVgskiagrpg------------------------pvltslyttAATIGIAAVALHLILYNTV 137
gi 124026996  87 QAVTGLAIVFLGIGLGDLVgsnaagtplps---------------------lslgvknyasLALLVLPAVVLYALLYRTW 145
gi 162148473  86 QIVTGLGFDMSAQAVCRLVvklafgvtgllslpaar---------rlpvvaipelgtldalTLLSWSLVPACAWFLRHHR 156
gi 14600420  126 EILSSLMINYIVLYMVNGLvsgplregaftkt-----------------rsieafvgpleaGLAAVSMAALSWILLERTS 188
gi 126465046  89 HGATGLSLMFLGYGLASLIglparnlqgrtgiei-------------gytlditnpmwigvYVITILLGIAFLYIINKTK 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                    ###################                                                 
gi 81344761  173 FGVHVRATGDQpYAVDGAGLSVFRLRSAAVVISGLCAGLGGGVLILTQDiqy-tvYSTHG---TGFIALAALISGRWHPF 248
gi 86607808  223 FGLQLRAVGKNpVAAFRLGIPATRRLLMAFACCGGLAGLAGALQVLALFhrl-ipNISSN---LGFLALLVVMLAGFNPL 298
gi 163849393 214 WGLEVRAVGLNpAAAGRLGVAAARRMLETLAACGALAGLAGMVQVVAVHhal-ipNISSG---IGLLGLLVALLARADPR 289
gi 81777224  171 LGLNLQAAGDKpAALDVAGIDVIRTRTIAVLTTGALAGLGGAYLANVGAglf-ipFITNG---AGFLGIVLAMLARGRPV 246
gi 124026997 211 LGVAIDAVGAArKAAETYGVDPRRTILAAAALSGAAAGLGGALYIVSIHtp--ltTIGKGglgYGYMGVLAAWLAGLRPL 288
gi 118430861 138 TGTALRVVGENpAAAKERGVPVWRLRLSAALVQGLSAGLAGYIMVAGLSygkwysGVTAG---LGWVALGIVILGYWTPI 214
gi 124026996 146 VGYAVRSLGEDvEAARFLGVNVAVYRLAVALTAGALAGIAGAFIFLSRPgtw-saGVALG---WGWLALGSVILGYWHPV 221
gi 162148473 157 LGLRLRAAGESpGAATALGFDPKRLQAAATIAAGVLAGLAGADLSLGIVgaf-stNISNG---RGFMALAAFYIGRARPF 232
gi 14600420  189 LGISLRASGPApRAADIYTIGRARAMLLSSLPQSLAAAAAGLILLGGIQtvftalKQPQG---YGYAAVLVSWMAELSPT 265
gi 126465046 156 LGASIRAAGEDpAAAEALGANVLSVRLIAGIIGFALIGLGGAIFEISYTqvw-seGQGLG---HGWLAFAISLSAGRHPL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                                                                  
gi 81344761  249 GVLVTSVLFGFSQI-----LNVYAtsvellkhlpielFSALPYa--------LTVVVL 293
gi 86607808  299 LILPIAFFFSSLNI-----GSLQLplslq---lesslAGVIQGs--------LVLFVL 340
gi 163849393 290 WLLPVTIAFAAFTV-----GSIQLpltlg---idsaiAGVLQGa--------LVLFAL 331
gi 81777224  247 WVLLGALLFGVCLS-----LTTAMqvagin--iptdvIQMLPFl--------AVMIML 289
gi 124026997 289 GALAAGMLLAVLYNm----VSMLQ-------------LQGIPAslvyafeaiLVLSVL 329
gi 118430861 215 GVLIASTAVSTVFS-----MRTQIaaatg----ipplADAIPYi--------LVLILL 255
gi 124026996 222 GVAAAAYLIGLANT-----LIMVLeglgv----pavvAENTPYi--------MVVVAL 262
gi 162148473 233 STAAACLMLGLLTE-----AAIHAqadgl----ptalAQAAPYl--------AVICVL 273
gi 14600420  266 TLIPVSLFFAWIAGagfilQAYGMps---------slVLLLQSia------lTVYMVA 308
gi 126465046 232 LILISAGVFAGLVN-----YMTAIqaays---lppdlAKMLPFvaa---ilaMVIFMA 278

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