2QNT,3ZI1,3ZI1,3HPY,4Z04,4GYM,1U69,1K4N,3B59,2ZI8,3E5D,3BQX,1JC5,4RT5,3RRI,3LHO,3EY7,2ZI8,3CT8,3R6A,1SQI,3ITW,2RBB,3KOL,2P25,2PJS,4LQB,4HC5,1KLL,2I7R,1SS4,1FRO,3VCX,1XQA,4MYM,3GHJ,1ZSW,2P7O,2ZW6,3B59,2R6U,2QQZ,1JIF,4N04,1ZSW,1SQI,2KJZ,1XY7,1EWJ,3PKV,3R4Q,1F9Z,1TWU


Conserved Protein Domain Family
VOC

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cd06587: VOC 
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vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.
Statistics
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PSSM-Id: 319898
View PSSM: cd06587
Aligned: 98 rows
Threshold Bit Score: 28.645
Threshold Setting Gi: 56967304
Created: 8-Jan-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2QNT_A       11 NPIPFVrd-----iNRSKSFYrdrlGLKILedf-----------gsFVLFe------------tGFAIHegrsleetiwr 62
1K4N_A       46 HISLRChqn--ataERWRRGFe--qCGELLsenxi-------ngrpICLFklhepvqvahwqfsIVELPwpgekry---- 110
1JC5_A       12 HVAYACpd-----aDEASKYYqetfGWHELhreenp-----eqgvvEIMMapaakl---tehmtQVQVMaplndestvak 78
3LHO_A       41 HIALRTfniakvnlSVLAKHFts-iGYVDSgdykfe-----qkkliAKHFehpd------pkqpKVFISellveefspev 108
1ZSW_A      183 SVELTVrr-----lDKMASTLteifGYTEVsrn-----------dqEAIFqsikg-----eafgEIVVKyldgptek--- 238
2P7O_A        7 HITLIVkd-----lNKTTAFLqnifNAEEIyssgdk----tfslskEKFFlia---------glWICIMegdslq----- 63
2QQZ_A       13 HVQVAApvg---ceEEARAFYgetiGXEEIpkpee------lkkrgGCWFkcg---------nqEIHIGveqnfn----- 69
1SQI_A      183 HIVGNQpdq---emESASEWYlknlQFHRFwsvddtqvhteysslrSIVVanye-------esiKMPINepapgrkksqi 252
gi 27468012   6 SVTLGTnd-----lSKTKELFnhiiGLQHStkn-----------ehAIRFgdanl-----spgtRVHFVevpeedy---- 60
gi 29375454 150 STEFHVpd-----sEKTLAFFetflGWQAVg--------------nTIILse----------teSFSVHqttsdkts--- 197
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2QNT_A       63 ts------------------------------------------sdaqeaygrrnxLLYFEHADvdaafqdiaphvel-- 98
1K4N_A      111 --------------------------------------------------phegweHIEIVLPGdpetlnaralallsde 140
1JC5_A       79 w--------------------------------------------lakhngraglhHMAWRVDDidavsatlrergvql- 113
3LHO_A      109 qksihglidqvdiaattadnfiysgrhwdvdkatyqallaeseyaawvaalgyranHFTVSINDlpeferiedvnqalkq 188
1ZSW_A      239 -------------------------------------------------pgrgsihHLAIRVKNdaelayweeqvkqrg- 268
2P7O_A       64 ---------------------------------------------------ertynHIAFQIQSeevdeyterikalgv- 91
2QQZ_A       70 ---------------------------------------------------pakraHPAFYVLKidefkqelikqgi--- 95
1SQI_A      253 q-------------------------------------------eyvdynggagvqHIALRTEDiittirhlrergmefl 289
gi 27468012  61 --------------------------------------------------knphidSVGLRTPSdsglveyqtifdkfn- 89
gi 29375454 198 ------------------------------------------------rmgrgsmdHIAFSVADdealqelhtralaqg- 228
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
2QNT_A       99 --------------------------------ihplerqawgqrvFRFYDPd-------------GHAIEV 124
1K4N_A      141 glslp--------------------gisvktsspkgeherlpnptLAVTDG--------------KTTIKF 177
1JC5_A      114 -------------------------------lydepklgtggnriNFMHPKsg-----------kGVLIEL 142
3LHO_A      189 agf-----------------------vlnssggevkgspevlleqSSTXADkvvvnftdgdveipSCFYEF 236
1ZSW_A      269 -------------------------------fhssgiidrfyfksLYFRESn-------------GILFEI 295
2P7O_A       92 ------------------------------emkperprvqgegrsIYFYDFd-------------NHLFEL 119
2QQZ_A       96 --------------------------------eviddharpdvirFYVSDPf-------------GNRIEF 121
1SQI_A      290 avpssyyrllrenlktskiqvkenmdvleelkilvdydekgyllqIFTKPMqd----------rpTLFLEV 350
gi 27468012  90 -------------------------------isyssitelnglkhFTFKDHn-------------QQKFDI 116
gi 29375454 229 -------------------------------weiemyvsrgyfksLYIREPg-------------GNRVEF 255
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