1U69,1U6L,3L20,1U7I,1TSJ,3OMS


Conserved Protein Domain Family
PhnB_like

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cd06588: PhnB_like 
Click on image for an interactive view with Cn3D
Escherichia coli PhnB and similar proteins
The Escherichia coli phnB gene is found next to an operon of fourteen genes (phnC-to-phnP) related to the cleavage of carbon-phosphorus (C-P) bonds in unactivated alkylphosphonates, supporting bacterial growth on alkylphosphonates as the sole phosphorus source. It was originally considered part of that operon. PhnB appears to play no direct catalytic role in the usage of alkylphosphonate. Although many of the proteins in this family have been annotated as 3-demethylubiquinone-9 3-methyltransferase enzymes by automatic annotation programs, the experimental evidence for this assignment is lacking. In Escherichia coli, the gene coding 3-demethylubiquinone-9 3-methyltransferase enzyme is ubiG, which belongs to the AdoMet-MTase protein family. PhnB-like proteins adopt a structural fold similar to bleomycin resistance proteins, glyoxalase I, and type I extradiol dioxygenases.
Statistics
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PSSM-Id: 319899
View PSSM: cd06588
Aligned: 57 rows
Threshold Bit Score: 94.2608
Threshold Setting Gi: 27469254
Created: 8-Jan-2008
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1U7I_A; dimer interface of phn-like protein from Pseudomonas aeruginosa, defined by 4A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        ######                   #                                   ##  #              
1U69_A         7 NTICLWYd----SAALEAATFYAETFpDSAVLAVHrapgdyp----sgkegdvLTVEFRVXGIPCLGLNGgpafr---hs 75
1U7I_A         7 VRPFLXFq---gVQAEAAXNFYLSLFdDAEILQIQrygaegp-----gpegsvLKALFRLGDQSVHCIDShvrhaf-dft 77
1TSJ_A         6 ITTFLXFn----NQAEEAVKLYTSLFeDSEIITXAkygengp-----gdpgtvQHSIFTLNGQVFXAIDAnsgt-----e 71
gi 81437194    4 FSPCLWFn----TQAEEAANFYTTIFeKGAILSKTnyvneeh----qpqgtslMTIEFTLANQTIIGLNGgpefs---ft 72
gi 29375508  135 IVPTFMFanekyGEAAKALSEWLAIFgPGEIIEKVeyed-----------gniAQALFTLQEQPFRVMDArdkhdf-dft 202
gi 16802859    4 AVPYLVFn----GEGQDALTFYADVF-QAKITSVQrfkemnnfdgdavfgerlMHSRLAKNGEEFIYITDapydgf-tig 77
gi 81406818    4 ITPFLMFd----NNLGEALKLYASTFsDWKLLSQNqtg------------dvvMSATFAISGKEILSFNGgphfk---ft 64
gi 222421725   3 LSPYIIV-----NDVKKAADFYNSIF-GGEIIILNqqk------------dkiLHAEVQINESTVIHLSSnygkp--fsn 62
gi 19552301    5 ISTYIAFn----GNTTEALKHWQEVF-GGELNLLTygqltlegmpfdppadalAHGVLTLDNGGLISGSDsfegemlvkd 79
gi 27469254    4 VSPFIYV-----KDVDKSLCYYKDVF-NAQTEILMgkd------------grtYHAQLIIGDETFVHFSDtfhkh--pvs 63
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
Feature 1          ###### #   #                             #         #  
1U69_A        76 eaFSFQVATDDqaETDRLWNAIVDNGgEESAc----------GWCRDKWGISWQIT 121
1U7I_A        78 paFSFFVDCESnaQIERLAEALSDGG-KALXplgdygfsqrfAWLADRFGVSWQLN 132
1TSJ_A        72 lpISLFVTVKDtiEXERLFNGLKDEG-AILXpktnxppyrefAWVQDKFGVSFQLA 126
gi 81437194   73 paSSFFVECTTlpQTETLWKNLTADG-QILMpfgeypfsplyGWVVDKFGVSWQVS 127
gi 29375508  203 maFSIYIDCENqeEIDRLWQQVTAKG-KEWPc----------GWMEDQFGVSWQTG 247
gi 16802859   78 nrVTILINFETedDIKYAYEVLSATG-KVEMelqvafwgstyAQVTDRFGVFWQLN 132
gi 81406818   65 paISFFLSCQTskEIEKIWASLSQEG-IVLMelqeypfsekfGWVQDKFGVSWQVC 119
gi 222421725  63 dnVNLILTFDNleEEQRVYHALSDNG-DPHMplaktffnsmhGQVKDQFGINWLMN 117
gi 19552301   80 taYSMLYNAESveDGRARIDKIVAAGgEEAMkfeqapwggffGQVFDKFGVMWNIS 135
gi 27469254   64 knPHLIIECDSleELERVYKRLIDDGgHAKVklnktffnayhAEVKDRLNGIIWVF 119

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