3EAU,4AUB,1PYF,1LQA,3V0U,1YNP,1M9H,4WGH,3UP8,4XK2,1PZ1,1OG6,2C91,4EXA


Conserved Protein Domain Family
AKR_SF
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cd06660: AKR_SF 
Click on image for an interactive view with Cn3D
Aldo-keto reductase (AKR) superfamily
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Links
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Statistics
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PSSM-Id: 381296
Aligned: 172 rows
Threshold Bit Score: 92.967
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3EAU: Rattus norvegicus voltage-dependent K+ channel beta subunit in complex with cortisone and cofactor NADPH, contacts at 4A.
    - View structure with Cn3D
  • Structure:1M9H: Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase in complex with cofactor NADH, contacts at 4A.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ###                                  #    #                                
3EAU_A      16 SCLGLGTWvtfggqi------tdemaeHLMTLAYdn-giNLFDTAEVYaag----kaEVVLGNIIKkkgw---rrsSLVI 81   Norway rat
AAF84538    20 NRLGFGAMritgpdvwg-epedhdeaiRVLKRLPei-gvDLIDTADSYgpf----vsEQLIADALHpy-------gGIKI 86  
OLP84158   634 TELGFGCMgitafyge---pmedakcvELLQAVYdm-gyRHFDSAEVYktet--khnEEQLAQFFKtvp-----reSYTI 702  Symbiodinium mic...
PRD37784    14 SAIGLGAMsfggifgp----tteteslACLDAMVea-giNFIDTANIYgmg----vsETVIGKWLAsr------rpDVVI 78   Nephila clavipes
AHD19084    14 SAIGLGCMrmsfgqkk---lpdrkemiKLIRTAVel-giNFFDTAEVYgpy----tnEELVGEALEpf------kgEVVI 79   Thermotoga marit...
Q06494      13 LDTGYGLMsltwraepipqsqafeamhRVVELSRerghkAFFNVGEFYgpd---finLSYVHDFFAkypd---lrkDVVI 86   baker's yeast
3V0U_A      15 SKLGFGCMglsgdynd---alpeeqgiAVIKEAFnc-giTFFDTSDIYgen---gsnEELLGKALKqlp-----reKIQV 82   serpentwood
KLO06561    27 SAIGLGTMrmgsadgt----sdvktahEALTYAAdh-gmTFWDTSDVYgd------gEEILGSWFTsnpt---rraSIFL 92   Schizopora paradoxa
Q56Y42      48 SPMGFGTWawgnqllwgyqtsmddqlqQAFELALen-giNLFDTADSYgtgrlngqsERLLGKFIKesqglkgkqnEVVV 126  thale cress
PSP87659    12 CRIINGYWqlsakhne----nqtstpvEDTAEFVda-glTTFDCADHYtg------vEELLGEFRNwyrrehgtdlPVQI 80   Halobacteriales ...

Feature 1        #                                                #                            
3EAU_A      82 TTKIfwggkaet---------erglsrkHIIEGLKASLERLqlEYVDVVFANRPdpnt------pmeeTVRAMTHVINQg 146  Norway rat
AAF84538    87 ATKGslvrypgnstn---pswpvigdpaYLRQCVYMSLRRLklEQIDLWQLHRIdpkv------praeQFGAIREFIDEg 157 
OLP84158   703 ATKFfpglhge-----------gpfdlaTVEKAVDASLARLglEYVDLYYCHRPpktwe-----laeqWMLAMKEIVAKg 766  Symbiodinium mic...
PRD37784    79 ATKAsivngppr---------sidnsagHLRTELEASLKRLgvERVDLFYIHRReqtr------pleeVIGTLQSLEAEg 143  Nephila clavipes
AHD19084    80 ATKFgfelyedgrp----gwkglnsnpeHIKKAVEGSLRRLrvEAIDILYQHRVdpnv------pieeVAGAVKELIEEg 149  Thermotoga marit...
Q06494      87 SCKGgadnatl----------tprgshdDVVQSVKNSVSAIg-GYIDIFEVARIdtslctkgevypyeSFEALAEMISEg 155  baker's yeast
3V0U_A      83 GTKFgiheigfsg-------vkakgtpdYVRSCCEASLKRLdvDYIDLFYIHRIdttv------pieiTMGELKKLVEEg 149  serpentwood
KLO06561    93 ATKFggrlptgtsftsphppntpisspsYIHHALQSSLKRLktTYIDLYYQHRVdpsv------pievVLLTLAPYLANg 166  Schizopora paradoxa
Q56Y42     127 ATKFaaypw--------------rltsgQFVNACRASLDRLqiDQLGIGQLHWStasyap---lqelvLWDGLVQMYEKg 189  thale cress
PSP87659    81 HTKIvpdrnrl-----------esvsraYIEGIVDRSRRRLcvDALDLVQFHWWdysvk-----nyvdAARHLADLRDEg 144  Halobacteriales ...

Feature 1             ##                          #                            #######         
3EAU_A     147 mAMYWGTSRWss--mEIMEAYSvarqfnlippiCEQAEYHMFqrekvevqLPELFHKigvGAMTWSPLACGivsgkydsg 224  Norway rat
AAF84538   158 lIRHAGLSQVsv--eAIEEARKvfp------vaTVQNRYNLAdra--dedVLDYCEAngiGFIPWFPLAAGdlakpggav 227 
OLP84158   767 kVKHVGLSEFspewtRKMHAIHpv--------aAIQIEWSLLtrnlveeiLLDCCKElniGVVAYSPLARNllavlptet 838  Symbiodinium mic...
PRD37784   144 kIGGYGLSEIap--eTLRAAHAihp------ctAVQNEYSLWsrqp-elgLIQECARlgtAFVAFSPLARGmlgatplrh 214  Nephila clavipes
AHD19084   150 kVKHFGLCEAsa--eTIRRAHKvcp------vdVVQYEYSMWwrkp-eeeILPTCEElgiGFVAYSPLGKGfltgaigen 220  Thermotoga marit...
Q06494     156 vIGGISLSEVne--eQIRAIHKdwgk----fltCVEVELSLFsndilhngIAKTCAElglSIICYSPLGRGlltgqlksn 229  baker's yeast
3V0U_A     150 kIKYVGLSEAsp--dTIRRAHAvhp------vtALQIEYSLWtrdi-edeIVPLCRQlgiGIVPYSPIGRGlfwgkaike 220  serpentwood
KLO06561   167 tIRWIGLSECsa--dTLRRAKSvegvg--ervvCVQDEFSPFslqverdgFAGVCEElgvSIVAYSPLGRGmmsgryksr 242  Schizopora paradoxa
Q56Y42     190 lVRAVGVSNYgp--qQLVKIHDylktr-gvplcSAQVQFSLLsmgkeqleIKSICDElgiRLISYSPLGLGmltgkysss 266  thale cress
PSP87659   145 kIRHIGVTNFda--pRLEALLDagv-----pvvSNQVQYSLLdtrp-ereMVDLCERrdmKLLCYGTLAGGfltskfage 216  Halobacteriales ...

Feature 1                                                      #                       ####    
3EAU_A     225 ippysraslkgyqwlkdk---ilseegrrqqaklkelqaiaerlgctLPQLAIAWCLRne-------gvSSVLLGAs--- 291  Norway rat
AAF84538   228 d-------------------------------------alakakgatAGQIALAWLLKrs-------pvILPIPGTs--- 260 
OLP84158   839 pedwrksvpryaee-----------nlarnkemlskieematkreatAAQLSLAWLYYkaaa---lgltMIAIPGDslpi 904  Symbiodinium mic...
PRD37784   215 nqvqdgfraqnprft--------epnfsrntaridrfrdwctqrgwsVPATALAWVMGag-------dhVLPIPGTr--- 276  Nephila clavipes
AHD19084   221 skfdeedirsriprfq-------kenlkenlalvellkkiaerkgatPSQIALAWLLAqk-------pwIVPIPGTt--- 283  Thermotoga marit...
Q06494     230 adipegdfrkslkrfsde--slkknltlvrflqeeivdkrpqnnsitLAQLALGWVKHwnkvpeysgakFIPIPSGs--- 304  baker's yeast
3V0U_A     221 slpensvltshprfv--------genleknkqiyyriealsqkhgctPVQLALAWVLHqg-------edVVPIPGTt--- 282  serpentwood
KLO06561   243 adfvptdvrlrfprfsea--nfpknlvlvdkfqevaaeyngadgvvtTNQIVLAWILAsr-------ptFIPLPGCr--- 310  Schizopora paradoxa
Q56Y42     267 klptgprsllfrq------------ilpgleplllalseiakkrgktMPQVAINWCICk---------gTVPIPGIk--- 322  thale cress
PSP87659   217 pdpgeatdlenrsltkykliieevggweayqnllgtvsdiadkhgvsIANVATRYVLEkp-------rvGSAIVGAr--- 286  Halobacteriales ...

Feature 1              #  ##  
3EAU_A     292 -----nAEQLMENIG 301  Norway rat
AAF84538   261 -----kVAHLEENVA 270 
OLP84158   905 klskeeADQLEELAA 919  Symbiodinium microadriaticum
PRD37784   277 -----rADRLREWLP 286  Nephila clavipes
AHD19084   284 -----kLSHLLENIG 293  Thermotoga maritima MSB8
Q06494     305 -----sISKVNENFD 314  baker's yeast
3V0U_A     283 -----kIKNLHNNVG 292  serpentwood
KLO06561   311 -----tPFHIAENAR 320  Schizopora paradoxa
Q56Y42     323 -----sVRHVEDNLG 332  thale cress
PSP87659   287 -----nTRHIESNQR 296  Halobacteriales archaeon QS_4_66_20

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