Conserved Protein Domain Family
Aldo_ket_red

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cd06660: Aldo_ket_red 
Click on image for an interactive view with Cn3D
Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits and aflatoxin aldehyde reductases, among others.
Statistics
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PSSM-Id: 119408
View PSSM: cd06660
Aligned: 1148 rows
Threshold Bit Score: 90.311
Threshold Setting Gi: 149917968
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1M9H; Corynebacterium 2,5-diketo-D-gluconic acid reductase with bound cofactor NADH, contacts at 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        ###                                   #    #                    
1M9H_A         5 SIVLn-dGNSIPQLGYGVYkvpp-------------adtQRAVEEALEVGYRHIDTAAIYg---nEEGVGAAIAasgiar 67
gi 16081541   15 FREFgktGEKISKIGVGTYydvgwmflarfgrksgsemkIRAIRTAVENGVTLIDTAEVYg---sEDLVARAIEgvd--r 89
gi 159042163   3 YRLFgksGVRVSAIGMGTYydplwiaasmiglkpsrnrkLQALRVGLENGINLIDTAEIYg---sEPIVGEAIRgfn--r 77
gi 15899596    3 KKPLgwtNEKISPLILGSWefgtpsi-------idennaIKAIQRAIELGINAIDTAESYgnglsETIIGRAISkfk--r 73
gi 91203129    3 FKNLs-nNIKIPVIGLGTWtigggdea----dttydkenISAIKTAIKLGITHIDNAEAYaqghsEELVGRAIVgld--r 75
gi 48477800    2 EFYLgktGERISSIGIGTWqmks------------ndqsIMAIRAGLDAGSNFVDTAEAYr---nEAMVGRAIEs----- 61
gi 16081208    6 TAEFdgtGRKVSVIGVGTWslegs-----------rsenVRSIRYALDHGVNFIDTAEMYg---tEDIVGEAIKgyr--r 69
gi 18312042    1 MKCAs-kAGCVPEIGLGTFgiggdfwrr---dnsrdfeaVKALRRGFELGLRLVDTSELYgeghaEELIKIASSgi---- 72
gi 18313935    3 RACFk-rVGCVPAIGLGTWgigggfwia---dtsrdaewIEAIKYAVEKGIKLIDTAEMYggghaEELVGRAIRgfa--r 76
gi 15899494    4 VKKFk--YFTVSPLAFGTWrigggywys---shdrdnewVGAIRRAIELGLRVIDTAEMYgnghaEELVGEAIKefs--r 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1               #                                ##                             ##       
1M9H_A        68 dDLFITTKLwndrhdgdEPAAAIAESLAKLaLDQVDLYLVHWPTpaadnyvhAWEKMIELRAAGlTRSIGVSNHlvPHLE 147
gi 16081541   90 eSLFIATKVwithlsydSAIKACKRSLKRLnMKYIDLYQIHFPSpigd-iegTLRAMEKLVDDGlIRYIGVSNFnlDQLK 168
gi 159042163  78 dELFIATKVwpshlkydSVIKAAQGSLRRLgVKYIDLYQIHFPNrrvp-ieeTMRAMEYLVDKGiVRFIGLSNFnlNQVI 156
gi 15899596   74 eDLFIITKVsidhlrydDVLKASEGSLKRLnTSYIDLYLVHWPNhyvp-ireTAKAMERLFNEGkIRYVGLSNFslPLMR 152
gi 91203129   76 kSLFITSKVspehlsydNLLASAKGSLQRLnTDYIDLYLIHAPNpdip-iqeTMKAMDFLVEQKlVRCIGVSNFsvDQIK 154
gi 48477800   62 rEVFIATKVfpnhfkydSLIRACENSLKRLnVKTIDLYQLHWPNrhvd-ikeTMKAMEHLVDTGmIRYIGVSNFnvNELK 140
gi 16081208   70 eDLFIATKVwpthfayhDVLKSCEESLKKLgTDYVDLYQLHWPNpsvs-ikeTMSAMEKLVDEGrIRYIGISNFsvKEMK 148
gi 18312042   73 eELLVITKIhpsslepgEVYKRLLGSTERL-GRRPWMVMLHWVPvgyh-icdVVKALESAVAKGlADNFGLSNVtaSQVS 150
gi 18313935   77 dELFIITKVwpnharydDVIKSAEASASRL-GTYIDLYLLHWPSdsvp-iceTIKAFEALVDRGvIRHFGVSNFslSQLQ 154
gi 15899494   77 eELFIVSKVwpshadydNVIKSAKNSSRRL-GTYIDLYLLHAPSrvp--ickTIRAFEKLVDDGvIRFFGLSNFdvDQIE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                      #                                  ######                         
1M9H_A       148 RIVAat-gvVPAVNQIELHPAYQQRe---------ITDWAAAHdVKIESWGPLGQGkydlfgaepv-------------- 203
gi 16081541  169 HAMEamkkyEIVSNQVHYSLRHRDPet-------dMIPFAEKNgMAILAWYPLEHGdlvrdeayptaf------------ 229
gi 159042163 157 EAQQalkkyEVTALQLPYSLVDRRIeg-------dIIPYAKKEnIAILCYYPLGHGrlvrefpsdli------------- 216
gi 15899596  153 EFREhlsktDVAANELHYNVLFRDVek-------eVLPYMLREnIPLLAYDALGLGyligrkevrneyrwyvlaretyik 225
gi 91203129  155 EAQKyt-knKIVANQIEYNLLVRDKgrvtenmeseIIPYCQENnIFIIAWRPLAKGklakpgfkil-------------- 219
gi 48477800  141 SAMSamskyEIVSNQVEYNPLVRYIep-------eISEFCRKNsISIIAYSPLMHGhdidpiskdesp------------ 201
gi 16081208  149 EAMSalakyRIVSNQLEYNVATREIed------egIYDFCRKNgMAIIAYSPLSHGkifgnemilet------------- 209
gi 18312042  151 AALTctkrmEPVAIENKYSLRYRRDel-------dVIPLAQREgLLYLGYSPLERGalaldsfla--------------- 208
gi 18313935  155 EAEAcakkyQLAAVQNHYSLYNRRDev-------dVIPYAQANgIMYIAYTPLEKGalardplla--------------- 212
gi 15899494  154 SAREcvskyEIVAIQNHYSLLSRSDer-------rALAYAEKNgLMYMAYTPLENGilarnefla--------------- 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
Feature 1                            #                ####    #  ##                   
1M9H_A       204 ---------taaaaahgktPAQAVLRWHLQk--gFVVFPGSVRREHLEENLDvfdFDLTDTEIAAIDAM 261
gi 16081541  230 -------lsdlrkrypemrASQIALSYLMEansnVFPIPRASNPDHVLENINsvkYHLSEGEIKILKDS 291
gi 159042163 217 --------nlvksnhgdktPAQIALNWIISkhenAFPIPRASNPIHVRENLDavgWRLSEEEIKAIEAW 277
gi 15899596  226 nleplieeissiakelgktPAQVVLNWLVSkd-nVFAIFNTTKEDHLKENLGslgWSLRDSDLRRLDEA 293
gi 91203129  220 ---------deladkyhktQAQIAINWLISkk-gIVVISKSTKVEHLEKNLGaigWKLRQEDTDRLNNE 278
gi 48477800  202 --------fniiankrnatVRQVILAWILSk--nFFAIPKSNVPEHVIENVKsmnINLSSEETSMIDHY 260
gi 16081208  210 --------ltdigkkygkrPAQVALNWIIRk--gAFPIPKASKPIHMAENIEstdFTLSDEDMKTLDSL 268
gi 18312042  209 ----------sigrkynksAVQVALNWYVKip-nVVPIVKASSASHVEEIAQsigWALSEEDWKLIDKQ 266
gi 18313935  213 ----------eigrkygitPVQAALAWYVKr--gVVPIPKAERKNHIDEIAGalgVELSDEDFARISSG 269
gi 15899494  212 ----------nigkkynktATQVALNWYITgknsLIPIVKASKIPHIEENAGamgWRLSEEDWRAIDEH 270

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