Conserved Protein Domain Family
GGCT_like

?
cd06661: GGCT_like 
Click on image for an interactive view with Cn3D
GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24, and the enzyme participates in the gamma-glutamyl cycle. Hereditary defects in the gamma-glutamyl cycle have been described for some of the genes involved, but not for C7orf24. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism. AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. The family also includes bacterial tellurite-resistance proteins (trgB); tellurium (Te) compounds are used in industrial processes and had been used as antimicrobial agents in the past. Some members have been described proteins involved in cation transport (chaC).
Statistics
?
PSSM-Id: 119400
View PSSM: cd06661
Aligned: 223 rows
Threshold Bit Score: 35.3983
Threshold Setting Gi: 157382488
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:putative catalytic residue [active site]
Evidence:
  • Comment:the highly conserved glutamic acid may serve as a general acid/base

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2PN7_A        19 YFAYGSNLLTerihlr-----npsaaFFCVARLQ--DFKLDFGnsqgktsqtwhggiATIFQSPGd-------------- 77
1V30_A        10 IAVYGTLRKGkplhwy-----lkgakFLGEDWIE--GYQLYFEy------------lPYAVKGKG--------------- 55
gi 81604796   13 VFCYGTLRAGeindigraaathgiaaPRLVGAVAvaGRLYDFGn------------yPGMVAGGGr-------------- 66
gi 85709661    9 LFFYGVLQDGlgpggqdw-pflkglgLGAKASVHgsLFAIPDEng----------wyPALIPTQArl------------s 65
gi 87300532  132 VFSYGSNLCPaqlarr----cprwdgSGLVARLE--GWRWGINkrrlgr--apgegaAGLVRHSGa-------------- 189
gi 87120958    9 IFGYGSLINAtsrak------tgetgQVWPVKIA--GYQRNWSvmste----fgmssVAVIPLKGa-------------- 62
gi 88798317    6 IFGYGSLICQdsrsr------tgvtsDACPVEVQ--GIQRRWSmhsp-------ewpATAVSAHDsp------------m 58
gi 156975586   3 IFGYGSLINAasrkl------tgqtgEASPVIAH--GLVRYWGkvdds-----yilsPLVVNEGEg-------------- 55
gi 154247794  24 LFGYGTLISEpsrtst-----shrqvVAVPARVSa-RFGLVRAfv----------arGGARSGAGftalglrqprdgevp 87
gi 89071104    5 FFGYGSLVNLath----------sypGARPARLS--GWRRVWRhstlr-----pvafLSVERHAGs-------------- 53
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                              #                                       
2PN7_A        78 -EVWGVVWKMn-kSNLNSLDEQEgvk---sgmYVVIEVKVAtqe-------gkEITCRSYLM 127
1V30_A        56 -KLKVEVYEVd-kETFERINEIEig-----tgYRLVEVSTK------------FGKAFLWEW 98
gi 81604796   67 dLVWGDVYAId-eRLVPVLDEIEevypgveglFVRQRASVElg--------grRYDCLYYPV 119
gi 85709661   66 sVVQGTIHDAs-gVDIAAIDAFEgp------nYTRQPMPVDgwd------gygETHADTYVW 114
gi 87300532  190 -HCWGVVHHHs-pDDRAALDHCEgva---aghYRHQRVQVItga-------geRLDALTYVP 239
gi 87120958   63 -YCNGVLIEIn-eSEIPSFDEREr-------gYERSQIQSEqlsayq-gqalpKGTIWIYHS 114
gi 88798317   59 hRCNGVYFAVd-aENLKNFDEREq-------gYQRIQLPWNqvsplseqslptGGTLWAYVG 112
gi 156975586  56 -QVNGVLLEVd-dQALAEFDRREr-------gYHRIQIRPDqieae--ttfnsEHSIWVYVK 106
gi 154247794  88 sSINGVVFPVldaGEMAAFDRREg-------gYRRVEVDPAlvegvgwqglprSGRVWIYVP 142
gi 89071104   54 -EIEGVVAEVp-dGDWAALDEREr-------aYVRRDVTDEvt--------haGPRAETAVY 98

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap