Conserved Protein Domain Family
SURF1

?
cd06662: SURF1 
SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.
Statistics
?
PSSM-Id: 119401
View PSSM: cd06662
Aligned: 196 rows
Threshold Bit Score: 78.9247
Threshold Setting Gi: 85373378
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723698    84 SFYLGTWQVRRLKWKTKLIAACet---------klTYEPIPLPksftpd-------------mcedweYRKVILTGHFLH 141
gi 50843774   38 MVFLGLWQMNVFESQRDDSTQAr-----------iNGPVITWNeapkka-------------dvmaqyGRRVTVTGTFQR 93
gi 171060495  26 TARLGFWQLDRGDQKSRLQTQIet---------rqQLPPLDRSelapdad------------taatqfDRQVQLQGRWVP 84
gi 55824355    9 CVRLGFWQLDRAAAKQALRAEVaa---------raALPPLAAAalaatpe------------aaaaqhYRRVTLAGRWLA 67
gi 124268360  72 TARLGAWQLSRAAEKEALQASLdt---------rgALPPLPAValardaa------------taagqwHRRITLAGRWRP 130
gi 120612541  35 TAALGRWQLARAAEKQAWQAMIda---------rqAMPPVPAAalaslppvagpesgspampaaealvHRPAVLRGRWLA 105
gi 118049283  26 TASLGFWQLSRAAHKQAVFDAIerqqalepwhnaeLAAEVALAaestgea------------qkatllHRPVQLRGQWLA 93
gi 160897127  21 TLSLGRWQLQRAAYKQQLFDAVqr---------qqGLPPLDNAqlapmqpgaa------lnteaapwlHRPVRLQGHWIA 85
gi 89900476    4 TLALGRWQLSRAAQKVAMQAGMea---------ksTMSILDGRvlaara-------------dpalelHRRVALRGQWIP 61
gi 91787148   24 TFSLGQWQLRRAAQKEALHAAVea---------knGLSPLDNQtffaik-------------dianetHRRVSIQGVWQP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723698   142 neemfvgprkKNGEKGYFLFTPFIRDdtg---ekVLIERGWISEEkvapdsrnlhhlslpqeehlkVVCLVRppkkRGSL 218
gi 50843774   94 stt-----tlIGTSWPVRVVTGIKLTtg----etMAIVRGKLSKGervpaa---------ptgvitVTGVLAaseaDDGR 155
gi 171060495  85 qgtvflenrqMHGRPGFFVVTPLLLDhg----daVMVQRGWVPRDgldrtrlpe---iatpdglqtLRGRMApppaRLYD 157
gi 55824355   68 drtvaldnrqVDGRPGFVLVTPLVLAdg----saVAVQRGWLPRDaaersriaa---pplpaalvqVAGQLApppsRLFA 140
gi 124268360 131 ehsvfldnrqMNGRPGFFLLTPLELApg----daVLVQRGWAPRDlrdrallpd---vptaggrveLVGQIApapaRLYA 203
gi 120612541 106 qdtvfldnrqMQGRPGFFVVTPLRLTspgaegavVLVQRGWVPRDfqdrtrlpa---vpapsedveVHGRIAaapsRLYE 182
gi 118049283  94 eqtlfldnrqMQGRAGFYVLTPFRLSapha-nrvVVVQRGWAPRNfmdrsvlpe---vqtpagtvsIEGRLEappsRLME 169
gi 160897127  86 gqslyldnrqMQGQPGFFVLTPLRLAaphe-dvvIAVQRGWVPRNfldrtalpe---vqtpeglvtVEGRMEaapsRLYE 161
gi 89900476   62 ertvfldnrpMNGRTGLYVVTPMRLEgsa---avVLVQRGWVARNfmdrshlpt---iespagvreIVGRIApppaKLYE 135
gi 91787148   82 ahtiyldnrpMGGKTGFWVLTPLALQgss---qvVLVQRGWVPRDftrrtrlpe---vstpaglvtVEGRIApppsKLYE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723698   219 QWAkkdpnsrl------wqvpdiydMARSSGctpiqfqalydmkdhpiieehtrneasqnnstsslwkfwkrepttavng 292
gi 50843774  156 RNSqmpaavl--------pslrlevLTQTWPqplvpatltldkknal--------------------------------- 194
gi 171060495 158 FGDagsgpi-----------rqnldLAAHAGslglrlrpwsvlqtdpv-------------------------------- 194
gi 55824355  141 FGAdapgaair-------qnldlgaWSAEIGvplrplslvqldgprt--------------------------------- 180
gi 124268360 204 FADeesgrlr--------qnividaYARETGlglrplsivqteggv---------------------------------- 241
gi 120612541 183 PGGpasaagsegss-rirqnldlaaYRAETGlqrlapltvietggp---------------------------------- 227
gi 118049283 170 LETanggadpdeqqsrirqnadialWAQQGGlpllalsvvqsgsa----------------------------------- 214
gi 160897127 162 FGRagadpdgqks--rirqnvdiaeWAVASGlplrewsllqtgea----------------------------------- 204
gi 89900476  136 LSGsdtglir--------qnidlagLAVETGlallpvsvqqtgaa----------------------------------- 172
gi 91787148  156 FKGedagrir--------qnldlnaFRVETGlpllgvallqtgap----------------------------------- 192
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1723698   293 tqavdnntskprsrqemptdqtiefderqfikagvpigrkptidlKNNHLQYLVTWYGLSFLSTIF 358
gi 50843774  195 -----------------------------aqglapaqpvlpkgdgGERNRGYALQWWVFAIFTVAM 231
gi 171060495 195 ----------------------------aasesplqrdwpspatgVQKHLGYATQWFALSALTAGL 232
gi 55824355  181 ------------------------------psdglrremplpsadVSRHQVYAGQWFLFAALAVVL 216
gi 124268360 242 ------------------------------pedgllrqwprpavdVHKHYGYAFQWFALATLLTGL 277
gi 120612541 228 -------------------------------egplqrdwpavdagVARHHGYAFQWFGLCALVAIL 262
gi 118049283 215 -------------------------------segllrdwpqinagVQKHYGYAFQWFGLSVLVVLL 249
gi 160897127 205 -------------------------------seglrrdwpvvtagVEKHHGYAFQWFGLAALITLL 239
gi 89900476  173 -------------------------------gdgmlrdwpqpavgVEKHYGYAFQWFALSSLIAIL 207
gi 91787148  193 -------------------------------gegllrewaapnlgVDKHYGYAFQWFALCSLVVVL 227
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap