1ZKO,2EDG,1ONL,1HPC


Conserved Protein Domain Family
GCS_H

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cd06848: GCS_H 
Click on image for an interactive view with Cn3D
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.
Statistics
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PSSM-Id: 133457
View PSSM: cd06848
Aligned: 150 rows
Threshold Bit Score: 70.255
Threshold Setting Gi: 71030316
Created: 30-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
lipoyl
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:lipoyl attachment site [posttranslational modification site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                      #                 
1ZKO_A        18 YTK-THEWVSIedk------vaTVGITNHAQEQLGDVVYvDLPEv-GREVKKGEVVASIESVKAAADVYAPLSGKIVEVN 89
1HPC_A         9 YAP-SHEWVKHegs------vaTIGITDHAQDHLGEVVFvELPEp-GVSVTKGKGFGAVESVKATSDVNSPISGEVIEVN 80
gi 193213848  15 YDSrYHFWAKPdptt----gnvVIGIDALGLDSAGELVYmSFHSa-GSRVRRHESLGSLEAAKMTGEILSPVSGTIIQRN 89
gi 146302183   9 YTK-NHLWLRQvgl-----ydyFVGITDFAQKEIGEISLiELEFt-GEHMKKEMQWGKIYGLNQTFSLLAPIDCKVMATN 81
gi 116750231 133 YHE-GHSWARIehg-----gfvRLGIDDFALRLLGSPTGiSLPKi-GTRLKRGENGWSIRREEHYASVLSPMDGTVMATN 205
gi 86158425   70 YAP-GHVWLHRrpgg----ravELGLDGIAQRLMPAVTAvDLARp-GTRVARGDTIATLHGGGRALEIPAPVDGTVVGLN 143
gi 94967798   58 YHP-GHTWALSesp-----nlvRVGIDDFAGKINGTVDKiNLPQr-GQWVRQGQKIWSIEKDGKKVDMVSPIEGSVAEIN 130
gi 153007115  68 YAP-NHTWLASaag------glRVGLDDFAQRLIPSTSAvDLPRp-GTQVRRGEPVAVVHAGGRSIRIGAPVDGVVVARN 139
gi 94969972   55 FHP-GHTWVADegh-----qnaRVGMDSFAAQLFGKIDRiETVEl-NRWVRQGQKLWTVTHNGTSVDMLSPIEGVVVSLN 127
gi 111018824  12 FTA-THSWLALapgqsfsdyplRAGVTDTALDEVEVVGL-ELPTvrSTIEAGAPCALVWTSARTVVTVYAPISGLVTMTN 89
                         90       100
                 ....*....|....*....|...
Feature 1                               
1ZKO_A        90 EKLDTEPeLINKDpegEGWLFKX 112
1HPC_A        81 TGLTGKPgLINSSpyeDGWMIKI 103
gi 193213848  90 TNVLEEPsIVNAEpygRGWFVLI 112
gi 146302183  82 VILDTNPsSINRDp-yNNWFLRV 103
gi 116750231 206 QSASKQPgLSKKDpygEGWLIVV 228
gi 86158425  144 VSVVRDPaLVKREgygRGWLVAL 166
gi 94967798  131 DAVLANPgLASKDpygEGWMITV 153
gi 153007115 140 GAVRRDPsLVKLEpygRGWLFTI 162
gi 94969972  128 HQVIKNPsSVGSDpykDGWVCVV 150
gi 111018824  90 TDAAENPqLVADDpfhRGWLFAV 112

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