1PMR,1GJX,1K8O,1QJO,1LAB,2PNR


Conserved Protein Domain Family
lipoyl_domain

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cd06849: lipoyl_domain 
Click on image for an interactive view with Cn3D
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.
Statistics
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PSSM-Id: 133458
View PSSM: cd06849
Aligned: 407 rows
Threshold Bit Score: 43.9323
Threshold Setting Gi: 197103322
Created: 29-Sep-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:lipoyl attachment site [posttranslational modification site]
Evidence:
  • Structure:2PNR; Lipoamide-containing lipoyl domain 2 (L2) of human pyruvate dehydrogenase kinase 3
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                                #                                  
1PMR_A         3 VDILVPdlpesvaDATVAtWHKKpGDAVVRDEVLVEIETDKVVLEVPASADGILdaVLEDEGTTvt-sRQILGRL 76
2PNR_G        28 MQVLLPalsptmtMGTVQrWEKKvGEKLSEGDLLAEIETDKATIGFEVQEEGYLakILVPEGTRdvplGTPLCII 102
gi 1352620     3 NEFKFTdvgeglhEGKVTeILKQvGDQIKIDEALFVVETDKVTTELPSPFAGTIsaINVKVGDVvs-iGQVMAVI 76
gi 42560815    2 FKVKFAdigegltEGIVAeVLVKvGDVVKEGQSLYFVETDKVNSEIPAPVAGKIavINIKAGQEik-vGDVVMEI 75
gi 110004304   2 VKFKFAdigegltEGKVAkIMIEvGDKIKDGVEMFAVETDKVNTEIYAPCDGIVskINMAVGDTiy-vGDVVVEI 75
gi 133930449   3 YIFRLPemgegltEGDVAsWLVKeGEAIKADDPLIEIQTDKSTTQLVSPVDGTVkkLFVKEDDHve-kGDKLAEI 76
gi 26553962    2 YIFKFAdigegihEGKVSdILVKeGDSVKDGTDLFSVETDKITTEVSSPVNGVIskILIKVGDTih-vGDPIFEI 75
gi 31544687    2 FEYKFTdvgeglhEGVVAqIYVKvGDTIKEGDPMFSVETDKVTTDLPAPEGGKVtaILASVGQTvh-vGEVMLVL 75
gi 49240342    4 YTFKFAdigeglhEGVVAeIYVKvGQQVKEGDNLFSVETDKVTSDIPSPVSGTVtaIKMAQGDTih-vGQDIFVF 77
gi 548423      2 YEFKFAdigegihEGTVLqWNFKvGDKVKEGETLVIVETDKVNAELPSPVDGTIvsLGAKEGEEih-vGQIIVTI 75

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