Conserved Protein Domain Family
PX_UP1_plant

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cd06879: PX_UP1_plant 
The phosphoinositide binding Phox Homology domain of uncharacterized plant proteins
The PX domain is a phosphoinositide (PI) binding module involved in targeting proteins to PI-enriched membranes. Members in this subfamily are uncharacterized fungal proteins containing a PX domain. PX domain harboring proteins have been implicated in highly diverse functions such as cell signaling, vesicular trafficking, protein sorting, lipid modification, cell polarity and division, activation of T and B cells, and cell survival. In addition to protein-lipid interaction, the PX domain may also be involved in protein-protein interaction.
Statistics
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PSSM-Id: 132789
View PSSM: cd06879
Aligned: 3 rows
Threshold Bit Score: 221.048
Threshold Setting Gi: 157339712
Created: 10-Jul-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
phosphoinosit..
Feature 1:phosphoinositide binding site [chemical binding site]
Evidence:
  • Comment:A majority of PX domain containing proteins binds phosphatidylinositol-3-phosphate (PI3P) at this site. In some cases, other phosphoinositides, such as PI4P or PI(3,4)P2, are the preferred substrates.
  • Comment:based on the structures of phosphatidylinositol-3-phosphate bound to other members of this superfamily
  • Comment:Two basic residues are key in binding with phosphoinositides: one forms hydrogen bonds with the 3-phosphate of PI(3)P and another forms hydrogen bonds with the 4-and 5-hydroxyl groups of PI(3)P.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                             ###        
gi 157339712  47 YCVIIPSWVVLPks--------------------------rDSDPVVFYRVQVGVQSPEGITTMRGVLRRFNDFLKLFTD 100
gi 75219603   48 YCVTIPSWIVLPksrnsdpvvsfiavhvirysnivelayiyNILDEQFYRVQVSVQSPEGITTMRGVLRRFNDFLKLLTD 127
gi 168051070  89 YCVFIPSWVAVPegkesdgkainpkv--gnmsvvyseyqplNNAVDKFFEVQVGIQSPDGISTLRPILRRFSDFLKLHAA 166
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
Feature 1                       ##              #                              
gi 157339712 101 LKKAFPKKNIPPAPPKGllr--mknRVLLEQRRRSLEEWMAKLLSDiDLSRSISVASFLELE 160
gi 75219603  128 LKRTFPRKGFPSAPPKGllr--mksRAVLEERRCSLEEWITKLLSDiELARSVVVASFLELE 187
gi 168051070 167 VKKLFPKKKLPAAPPKNslmrinsnQALLKERRHTLEDWMGRLLADiDISRSVPLASFLELE 228

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