2OFQ


Conserved Protein Domain Family
VirB9_CagX_TrbG

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cd06911: VirB9_CagX_TrbG 
Click on image for an interactive view with Cn3D
VirB9/CagX/TrbG, a component of the type IV secretion system.
VirB9 is a component of the type IV secretion system, which is employed by pathogenic bacteria to export virulence proteins directly from the bacterial cytoplasm into the host cell. Unlike the more common type III secretion system, type IV systems evolved from the conjugative apparatus, which is used to transfer DNA between cells. VirB9 was initially identified as an essential virulence gene on the Agrobacterium tumefaciens Ti plasmid. In the pilin-like conjugative structure, VirB9 appears to form a stabilizing complex in the outer membrane, by interacting with the lipoprotein VirB7. The heterodimer has been shown to stabilize other components of the type IV system. This alignment model spans the C-terminal domain of VirB9. CagX is a component of the Helicobacter pylori cag PAI-encoded type IV secretion system. Some other members of this family are involved in conjugal transfer to T-DNA of plant cells.
Statistics
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PSSM-Id: 132874
View PSSM: cd06911
Aligned: 137 rows
Threshold Bit Score: 52.5838
Threshold Setting Gi: 161986690
Created: 8-Jan-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
VirB7
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:VirB7 interaction site
Evidence:
  • Structure:2OFQ: NMR structure of a complex between the C-terminal domain of VirB9 and a VirB7 interaction domain as exemplified by the homologs TraO and TraN from plasmid pKM101, contacts at 4 A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1             #######              ######                                                
2OFQ_A         1 AGAKNYQYVMSEqp-------eMRSIQPVHVWDNYRFTRFEFPa---------nAELPQVYMISas----gkETLPNSHV 60
gi 121610622 174 DASQLAFYSVRTd---------NTQYQRMHVYSDGVKTWMRLPpg--------vQDLPAVFMVDkdqrgreqLMPVNYTV 236
gi 91791046   31 VGQYDFTYFTSG----------EQRATPVQVFDDGKSTYFQFRa---------gEAIPAIFNNKdg-----kVSLLVPYF 86
gi 153887080  36 NQNYDFAYQTSG----------GTGVRPSQVFDDGTKTYFQFPi---------gKFAPVIELDEgg-----rRKLLEPMQ 91
gi 161789262 176 EALRKYRYHIYTrykydegkafVGNNTISDVYDDGRFTYIRLAnp--------nRGVLSVETMIggk---naIAPVKYDD 244
gi 89885738   28 GDAFDFGYRSAG----------ENDLKPVQAFDDGERTYLQMKg----------ALVPVVLASVd-------GKMTMLQV 80
gi 91791256   27 MDRFNFDYAVQG----------DSRAKPLQVFDDGQRTYLQYRa---------sDDIPAFISTRt-------AQLLIPRQ 80
gi 149187067 133 VPPDTGQYRLRG----------DRAVRPAAISDDGTKTYLIWGe---------eQAMPAVFAIGps----gkEEMVEGYM 189
gi 121582821 185 PISPNNLVFFRVe--------gNKEYERMHAYDDGRMTFIRMPpg--------iQDLPALFLVDtd----nkLVPINYTV 244
gi 172064591  25 TDPFDFDYEIMG----------GIAERPALIFNDGAKTYIQPRagqvitadgghNEGPYVVVDGt-------PQTISYKV 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
Feature 1                                #             #######   
2OFQ_A        61 VGen-------rNIIEVETvaKEWRIRLG---------DKVVGVRNNN 92
gi 121610622 237 ADrenl---rdrDVIIIDRtaALWMLRIG---------QSIEVRVARD 272
gi 91791046   87 EG----------PYIRVQEtsGRFTLQLG---------RAQAQVVYGG 115
gi 153887080  92 EG----------LYYTVPLigNRFVLQRG---------QETAVVEYDG 120
gi 161789262 245 AY----------GMYRITGiyPKFTLRVD---------DVKIIVTRSD 273
gi 89885738   81 KNn--------gQYLVVPAitNKLTLQFA---------NLSAKVTYTG 111
gi 91791256   81 EG----------PYTVLNGtpGDFVAQLG---------ASSARITHSS 109
gi 149187067 190 RG----------GVYTIDRvyAELVFRID---------KEKARAKRRR 218
gi 121582821 245 LDrkgh---ddrDVLKVERtnPKWLLKIK---------KSVEVKLTKE 280
gi 172064591  88 AGraatarwkkaNTFIGGTg-TLAALHDDqpagfdgftNRLTIIGTRG 134

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