1XV9,1ILG


Conserved Protein Domain Family
NR_LBD_PXR_like

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cd06934: NR_LBD_PXR_like 
Click on image for an interactive view with Cn3D
The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
The ligand binding domain of xenobiotic receptors: This xenobiotic receptor family includes pregnane X receptor (PXR), constitutive androstane receptor (CAR) and other related nuclear receptors. They function as sensors of toxic byproducts of cell metabolism and of exogenous chemicals, to facilitate their elimination. The nuclear receptor pregnane X receptor (PXR) is a ligand-regulated transcription factor that responds to a diverse array of chemically distinct ligands, including many endogenous compounds and clinical drugs. The ligand binding domain of PXR shows remarkable flexibility to accommodate both large and small molecules. PXR functions as a heterodimer with retinoic X receptor-alpha (RXRa) and binds to a variety of response elements in the promoter regions of a diverse set of target genes involved in the metabolism, transport, and elimination of these molecules from the cell. Constitutive androstane receptor (CAR) is a closest mammalian relative of PXR, which has also been proposed to function as a xenosensor. CAR is activated by some of the same ligands as PXR and regulates a subset of common genes. The sequence homology and functional similarity suggests that the CAR gene arose from a duplication of an ancestral PXR gene. Like other nuclear receptors, xenobiotic receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132732
View PSSM: cd06934
Aligned: 7 rows
Threshold Bit Score: 361.353
Threshold Setting Gi: 61679484
Created: 1-Dec-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1XV9_B         4 LSKEQEELIRTLLGAHTRHMGtmFEQFVQFRPPahlfihhq--------------------------------------- 44
gi 82135355   32 LTPQQEAVIQELLNAHKKTFDmtCAHFSQFRPLdrdqksvsesspltngswidhrpiaedpmq----------------- 94
gi 82259035  100 LSSQQEETIRELVCSHRKTFDpaFYRFTLFHRPkvrvgfssgfsqpmdrniftvgdssrsgdapsav------------- 166
gi 185134293 126 LSPQQEAVIQELFNAHEKTFDi-TFSHFQFRPIdrdlnpmsvwnqtaseqsvkqtrrmdnlsssystststsfsssscsl 204
1ILG_A        25 LTEEQRMMIRELMDAQMKTFDttFSHFKNFRLPgvlssgcelpeslqapsreeaakwsqvrkdl---------------- 88
gi 82220627  127 LTAEQQELISILIAAHKRTFDssFSQFQHYQPAvrlcipgpcsqsppgpgvp---------------------------- 178
gi 410518    138 LTPEQQHFLTQLVGAHTKTFDfnFTFSKNFRPIrrssdptqe-------------------------------------- 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                ##  ##  #               
1XV9_B        45 -------------------------------------------plptlapvLPLVTHFADINTFMVLQVIKFTKDLPVFR 81
gi 82135355   95 ---------------------wvfnptslssssssyqsldnkekkhfksgnFSSLPHFTDLTTYMIKNVINFGKTLTMFR 153
gi 82259035  167 ------------------gplspscsslpsvpprgetqqsregeearragvFTALPHVTDLTTYMIHDIIAFSKSLTHFK 228
gi 185134293 205 edeekedrsggkntvfttlpdvadlttnmeekkeeekekkedrsdggkntvFTTLPHIADLTTYMIQNIINFAKGLPSFR 284
1ILG_A        89 ---------------------cslkvslqlrgedgsvwnykppadsggkeiFSLLPHMADMSTYMFKGIISFAKVISYFR 147
gi 82220627  179 --------------------------------saslspqldcldedvlpdvFSILPHFADLSTFMIQQVIKFAKEIPAFR 226
gi 410518    180 -------------------------------------------pqatsseaFLMLPHISDLVTYMIKGIISFAKMLPYFK 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                           #  #          #      #   ##    #   ##  #                     
1XV9_B        82 sLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYtieDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLA 161
gi 82135355  154 aLVMEDQISLLKGATFEIILIHFNMFFNEVTGIWECGPLQYcmdDAFRAGFQHHLLDPMMNFHYTLRKLRLHEEEYVLMQ 233
gi 82259035  229 sLLIGDQMALLKGATFEVMEIRFNMVFNTKTGVWECGHATYcieDAVRAGFQPLLLEPLLRFHHTLRNLGLEEEEYVLMQ 308
gi 185134293 285 aLAIDDQISLLKGAMFEMMQIRFNMMFNVKTGIWECGPLTYcmdDAVRAGFQRHLLDPLMRFHYTLRNLQLQEVEYVLMQ 364
1ILG_A       148 dLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYc-lEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQ 226
gi 82220627  227 gLPIDDQISLLKGATLGICQIQFNTVFNEETNAWECGQHCFtikDGALAGFQQIYLEPLLKFHISLKKLRLHEAEYVLLV 306
gi 410518    217 sLDIEDQIALLKGSVAEVSVIRFNTVFNSDTNTWECGPFTYdteDMFLAGFRQLFLEPLVRIHRMMRKLNLQSEEYAMMA 296
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1XV9_B       162 AMALFSPDRp------------------------------GVTQRDEIDQLQEEMALTLQSYIKGqqrr-prdrFLYAKL 210
gi 82135355  234 ALSLFSPDRp------------------------------GVTDHKVIDRNQETLALTLKTYIEAkrng-pekhLLFPKI 282
gi 82259035  309 AMSLFSPGRtrsaplvsdgpqgwfvstplqsvcfklsdrsGVQEHGVIDRIHENMALTLKTRIDSkrtg-pekrMLYPKV 387
gi 185134293 365 AISLFSPDRp------------------------------GVINHGVIDSLQEKLAIALKVHIDSkrak-pekhLLYPKI 413
1ILG_A       227 AISLFSPDRp------------------------------GVLQHRVVDQLQEQFAITLKSYIECnrpq-pahrFLFLKI 275
gi 82220627  307 AMLLFSPDHa------------------------------SVTQRDFIDQLQEKVALTLKSYIDHrhpm-pegrFLYAKL 355
gi 410518    297 ALSIFASDRp------------------------------GVCDWEKIQKLQEHIALTLKDFIDSqrppspqnrLLYPKI 346
                        330       340       350
                 ....*....|....*....|....*....|....*..
Feature 1                     #                       
1XV9_B       211 LGLLAELRSINEAYGYQIQHIQGLSAm---MPLLQEI 244
gi 82135355  283 MGCLTEMRSMNEEYTKQVLKIQDMQPe--vSPLWLEI 317
gi 82259035  388 LACLTEMRTLTQEYSKQILQIQDIQPnv-mPPLMVEM 423
gi 185134293 414 LACLTEMRTMNEEYTKQVLQIQDIQPgnsfDPLILEV 450
1ILG_A       276 MAMLTELRSINAQHTQRLLRIQDIHPf--aTPLMQEL 310
gi 82220627  356 LLLLTELQTLKMENTRQILHIQDLSSm---TPLLSEI 389
gi 410518    347 MECLTELRTVNDIHSKQLLEIWDIQPd--aTPLMREV 381

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