3CQV,2V0V,2V7C


Conserved Protein Domain Family
NR_LBD_REV_ERB

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cd06940: NR_LBD_REV_ERB 
Click on image for an interactive view with Cn3D
The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
The ligand binding domain (LBD) of REV-ERB receptors: REV-ERBs are transcriptional regulators belonging to the nuclear receptor superfamily. They regulate a number of physiological functions including the circadian rhythm, lipid metabolism, and cellular differentiation. The LBD domain of REV-ERB is unusual in the nuclear receptor family by lacking the AF-2 region that is responsible for coactivator interaction. REV-ERBs act as constitutive repressors because of their inability to bind coactivators. REV-ERB receptors can bind to two classes of DNA response elements as either a monomer or heterodimer, indicating functional diversity. When bound to the DNA, they recruit corepressors (NcoR/histone deacetylase 3) to the promoter, resulting in repression of the target gene. The porphyrin heme has been demonstrated to function as a ligand for REV-ERB. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, REV-ERB receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132738
View PSSM: cd06940
Aligned: 9 rows
Threshold Bit Score: 314.815
Threshold Setting Gi: 148226871
Created: 19-Nov-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindinghomodimer
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1CQV_a; human Reverb Beta In Complex With Heme, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                         #  #   #   #                             #  ##  #   #           
3CQV_A          9 SPYVDPHks---gHEIWEEFSXSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLXVRFASLFDAKERTVTFLS 85
gi 121582432  219 CPLNPNPqpltgqQELLQDFSKRFSPAIRGVVEFAKRIPGFsLLAQDDQVTLLKAGVFEVLLVRLACMFDAQTNSMICLN 298
gi 71153513   609 CPLNPAPe-----LQSEQEFSQRFAHVIRGVIDFAGMIPGFqLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLN 683
gi 14994043   402 SPYVDPQks---gHSIWEEFSMSFTPAVREVVEFAKRIPGFkDLSQHDQVSLLKAGTFEVLVVRFTSLFDVKERKVTFLS 478
gi 148226871  328 LHQGGPVrs---vQEVWEHFSLSFTPAVREVVEFARHIPGFnDLTQNDQVTLLKAGTFEVLMVRFASLFDARERSLRFLS 404
gi 45383934   359 TPHVDPNks---gHEVWEEFSLSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLMVRFASLFDARERTVTFLS 435
2V0V_A          4 SPYVDPHks---gHEIWEEFSMSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLG 80
2V7C_A          4 SPYVDPHks---gHEIWEEFSXSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLXVRFASLFDAKERTVTFLS 80
gi 189066703  389 SPYVDPHks---gHEIWEEFSMSFTPAVKEVVEFAKRIPGFrDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLS 465
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                          ##  #                                                          
3CQV_A         86 GKKYsvddlh-sxgagDLLNSXFEFSEKLnaLQLSDEEXSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIXKNH 164
gi 121582432  299 GQVLkresihnssnarFLMDSMFDFAERVnsLRLSDAELGLFCSVVVIAADRPGLRNTELVERMHNKLRNALQTVLAQNH 378
gi 71153513   684 GQVMrrdaiqnganarFLVDSTFNFAERMnsMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNR 763
gi 14994043   479 GRKYsvdalr-slgagDLLNSMFDFTEKLqaLNLSEEEMSLFTAVVLVSADRSGLENVNSVEALQETLIRALRSLITKNH 557
gi 148226871  405 GATYslpelh-amgmgELLGSMFDFSEKLssLSLSQEELGIFTALVLVSADRSGMENSSLVEQLQETLIRALRSLILKNS 483
gi 45383934   436 GKKYsvddlh-smgagDLLNSMFEFSEKLnaLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH 514
2V0V_A         81 SKKYsvddlh-smgagDLLNSMFEFSEKLnaLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH 159
2V7C_A         81 GKKYsvddlh-sxgagDLLNSXFEFSEKLnaLQLSDEEXSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIXKNH 159
gi 189066703  466 GKKYsvddlh-smgagDLLNSMFEFSEKLnaLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNH 544
                         170       180       190
                  ....*....|....*....|....*....|...
Feature 1                                #  ##  #  
3CQV_A        165 PNeasIFTKLLLKLPDLRSLNNXHSEELLAFKV 197
gi 121582432  379 PQhpdILRELLKKIPDLRTLNTLHSEKLLAFKM 411
gi 71153513   764 PDqpeFLAKLLETMPDLRTLSTLHTEKLVVFRT 796
gi 14994043   558 PNeiaIFTKLLLKLPDLRSLNNMHSEQLLAFKV 590
gi 148226871  484 PNdtsRFTKLLLRLPDLRTLNNLHSEKLLSFRV 516
gi 45383934   515 PNeasIFTKLLLKLPDLRSLNNMHSEELLAFKV 547
2V0V_A        160 PNeasIFTKLLLKLPDLRSLNNMHSEELLAFKV 192
2V7C_A        160 PNeasIFTKLLLKLPDLRSLNNXHSEELLAFKV 192
gi 189066703  545 PNeasIFTKLLLKLPDLRSLNNMHSEELLAFKV 577

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