Conserved Protein Domain Family
NR_LBD_DmE78_like

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cd06941: NR_LBD_DmE78_like 
The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily.
The ligand binding domain (LBD) of Drosophila ecdysone-induced protein 78 (E78) like: Drosophila ecdysone-induced protein 78 (E78) is a transcription factor belonging to the nuclear receptor superfamily. E78 is a product of the ecdysone-inducible gene found in an early late puff locus at position 78C during the onset of Drosophila metamorphosis. Two isoforms of E78, E78A and E78B, are expressed from two nested transcription units. An E78 orthologue from the Platyhelminth Schistosoma mansoni (SmE78) has also been identified. It is the first E78 orthologue known outside of the molting animals--the Ecdysozoa. SmE78 may be involved in transduction of an ecdysone signal in S. mansoni, consistent with its function in Drosophila. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, E78-like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132739
View PSSM: cd06941
Aligned: 6 rows
Threshold Bit Score: 270.033
Threshold Setting Gi: 115682407
Created: 19-Nov-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ##   #                                 #   #  #                        # # 
gi 212510079  102 IWLWQQFASHVTPSVQRVVEFAKRVPGFcdLSQDDQLILIKVGFFEIWLGHVSRQTCds--------------smTFTDG 167
gi 115682407  272 RNQWVQLAHILDQAVSGQVEFAKAIPGFrnLTQDDQLLLLKSSFFEMWVVRIAPLLMipsaphtnngmgplmaslTMDMH 351
gi 167650894  506 LRMHEELSQLLAPCIQHVVEFAKRIPEFssLGQPDQLVLIKAAFFEVWLVQASRLIStnd------------rkiTLADG 573
gi 74938962   119 YQLWHSLNEAMFEDLGRFIEFTKRIPGFvnISHKDQLLAVKTAFFEVWLVWISHTMNskt------------gtiTFSHG 186
gi 72054366   195 CTVKGYLTDVLTPSVVNVVQFSKNLPGFcdLLQEDQMTLLKAGFFEIWLLRTCMEIAftsd----------svsfGTDHG 264
gi 34223729   663 IWLWQQFSARVTPGVQRIVEFAKRVPGFcdFTQDDQLILIKLGFFEVWLTHVARLINea--------------tlTLDDG 728
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                     #                                                   
gi 212510079  168 tyitkqqm------------dliydpeFVSSLFHFAASFnaLALNDTELGLFSAVVLLSADrp-gVADIKVIEQHQDRLI 234
gi 115682407  352 hspssgvngmgtgsllwqqlyhvfgsdLYHAMHQFSQEFnqLGLLETEVALYASSLLAANDim-gLSNPQAVAELQHQLV 430
gi 167650894  574 kqitkqel------------dfiyspsVVCSIFSFSENFnsLVLNDTEVALCCAAVITKPNry-gLIEPNKVAIIQDHHL 640
gi 74938962   187 isfsreql------------siiygvvLIKQMFEFGDRFmsYKLSESLLGLYCAVLLLTQDnipkLEKPHKMLILRERVM 254
gi 72054366   265 yamshls-------------mlgcdyrFWDELFDFSRSFnnLQLIKEEIALFTTVVLFSPDrh-gLVEPGKVEVLQDRYL 330
gi 34223729   729 ayltrqql------------eilydsdFVNALLNFANTLnaYGLSDTEIGLFSAMVLLASDra-gLSEPKVIGRARELVA 795
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
Feature 1                                              #                           
gi 212510079  235 EALKVQVgrnha---sdpqLFSSLLMKLPELRNLGAKHSAHLDWFRINWql--lrLPPLFAEIFD 294
gi 115682407  431 EALQVQVdgnhp--saaapLMATLYGRVQELRRIGGMHRDFVMGCSQRWpdlcpgLPALYTEMMD 493
gi 167650894  641 AALRMQLernrp---reatLIGQVRNVINQVTTVGDEVQLCIRWYRENWyr--trLAPLYAETYD 700
gi 74938962   255 YALKLQLsterp---aeseLFHSLLVKRELLRSIAIRHQMALDWYRVHLdl--irLPQIFVDLYD 314
gi 72054366   331 ECLKREVtrrdw---knkqLFARLLMQATNLRAVSAIFFKSTSEFRHAWpy--meIPALLQEILN 390
gi 34223729   796 EALRVQIlrsragspqalqLMPALEAKIPELRSLGAKHFSHLDWLRMNWtk--lrLPPLFAEIFD 858

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