Conserved Protein Domain Family
NR_LBD_Sex_1_like

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cd06942: NR_LBD_Sex_1_like 
The ligand binding domain of Caenorhabditis elegans nuclear hormone receptor Sex-1 protein
The ligand binding domain (LBD) of Caenorhabditis elegans nuclear hormone receptor Sex-1 protein like: Sex-1 protein of C. elegans is a transcription factor belonging to the nuclear receptor superfamily. Sex-1 plays pivotal role in sex fate of C. elegans by regulating the transcription of the sex-determination gene xol-1, which specifies male (XO) fate when active and hermaphrodite (XX) fate when inactive. The Sex-1 protein directly represses xol-1 transcription by binding to its promoter. However, the active ligand for Sex-1 protein has not yet been identified. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, Sex-1 like receptors have a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132740
View PSSM: cd06942
Aligned: 11 rows
Threshold Bit Score: 181.394
Threshold Setting Gi: 24418858
Created: 9-Dec-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative ligandputative
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:predicted based on homologous proteins.
  • Citation:PMID 9744270

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              ##   #                                 #   #  #             # #            
gi 3882948    296 LNAWQIYAHEIDVDIKEVVNFVKEIPKFnfINGNDKAVLLRKNAFPLYLLRIVRGMSnr---glMLRDGRlidfksl--- 369
gi 88595434  1306 EDIWGQMMKHFETHSRFIVQFVKYIPGFcyLKISDQRQLVRSAMYPIMLLELSRDYVnedrtryNYFDFTpeehaiil-- 1383
gi 74906875   298 LNAWKVFGHNIEMEVQNAIYFVRDIPRTefVSGDDKAALLKKNIFGIYLCRIFRSLSee---gmVMHDGRvtnvptl--- 371
gi 152148438  306 QTICPVGRANAHHAIKAAYDFSQSIPGFnmLHHQDRVQLLKGTLFQTIVLAMLSSFNsn---ktLLMFQSpvgqy----- 377
gi 39984732  1132 NQVWGHMMNHFHMHAQQVVQFAKLVPGFnqLGITARSNLVREAMYSVLLLLLSRDYCpet-deyNYFDFPakerevim-- 1208
gi 156630606  169 FEKMGKIATSMEKNIRNIVEFVRLIPGYsqLSTKDRLQLIKSCFSDYWFLAAHKRINle---lqVVCGSVnahfdel--- 242
gi 24418858   384 AGGWELFARELNPLIQAIIEFAKSIDGFmnLPQETQIQLLKGSVFELSLVFAAMYYNvd---aqAVCGERysvpfaclia 460
gi 170593425  251 FDAWKKFAAELTRIIQCIIEFAKMVEGFmqLSQEEQIALLKGCVFELAAIVVTRHYNpe---ttSLILSRevfpasifrp 327
gi 88595436  1651 EIFWHHLMKYFESHIYEIIQFAQSIPNFqeLSEFDMKILIQQSIYPIILIQLSQDFNnnk--tkEYYYFNiqsqtsli-- 1726
gi 39653635  1132 NQVWGHMMNHFHMHAQQVVQFAKLVPGFnqLGITARSNLVREAMYSVLLLLLSRDYCpet-deyNYFDFPakerevim-- 1208
gi 1705961    296 LNAWQIYAHEIDVDIKEVVNFVKEIPKFnfINGNDKAVLLRKNAFPLYLLRIVRGMSnr---glMLRDGRlidfksl--- 369
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                 #                                                                       
gi 3882948    370 -qllygsLADEMLAFANHIi-tIGCTDGDIALFIVLILCQPLt----------tEQQFSTNFKSQLQLLEMFDFYKkvlf 437
gi 88595434  1384 shfptfhKISGHLIRSGEFltrLNLDNIELTLMCAQEVFKDRqg---------lDDPVTPAYLFNLVGLALTEHIIsvgy 1454
gi 74906875   372 -rllfgcLADEMIQFAVYCr-nIGVSDADMAILAALVLVQPAg----------lDYRQDVQNKGPPGLAQLIQFFQnmmh 439
gi 152148438  378 ---vhqyFYSPLNVFLQKFn-tLKLTNQQVALIGAAGMCISDkp---------lLHHPELAAFIHNRLSDLFQETFse-- 442
gi 39984732  1209 rhfptfkRITEHLRVSGRImhhLNLSLPELSLSCAAEILRNY------------CILEEPTAKSTAELFVLAHHSLlncm 1276
gi 156630606  243 lglmhkdYLDEICQVTTKLq-kCNMTIEEVTLLRAITLTAGD------------RCDLENPAKVEEIQWKLISFLRsllk 309
gi 24418858   461 eddaemqLIVEVNNTLQEIv-hLQPHQSELALLAAGLILEQVssshgigildtaTIATAETLKNALYQSVMPRIGC---- 535
gi 170593425  328 seqaelnFFLGMHSCIHELa-qLRLTNAEMGLLSAWILLDRSs----------lGQFVIEQFRNCLQQQIATRIAD---- 392
gi 88595436  1727 nqfsvckILFEQINLTNKLlksLDLNETEIGLLCCVELFHTD------------GKYLNEPIKINEAYQTILQLLKeyet 1794
gi 39653635  1209 rhfptfkRITEHLRVSGRImhhLNLSLPELSLSCAAEILRNY------------CILEEPTAKSTAELFVLAHHSLlncm 1276
gi 1705961    370 -qllygsLADEMLAFANHIi-tIGCTDGDIALFIVLILCQPLt----------tEQQFSTNFKSQLQLLEMFDFYKkvlf 437
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                      #                                                  
gi 3882948    438 qkmtcridgcdTYKQLMKCIHELNRLNELHKQQLnilr------------------------------------------ 475
gi 88595434  1455 -------slegRYAALSLISPMLEELNIEHHEVIaqlr------------------------------------------ 1485
gi 74906875   440 kklcshpngydIVFNFHKLVPALNGINNMLDEAFvkflr----------------------------------------- 478
gi 152148438  443 ---------ecRAAAPQLLHTVLCELRMQNAVHQqsleaitiwpttccsssssvasnsddstnsntvktglsdsasrnie 513
gi 39984732  1277 akh-svptvasTQQRRTQLFALRKMIRVMDKEHHgiladl---------------------------------------- 1315
gi 156630606  310 k------sydnPEQRLWQLFDIMTSLRNLESVAKnihal----------------------------------------- 342
gi 24418858   536 -----------MEDTIHRIQDVETRIRQTARLHQealqnfr--------------------------------------- 565
gi 170593425  393 -----------SGPLMQKLCEIIQRLRGHAQEHIrllgqlft-------------------------------------- 423
gi 88595436  1795 isl-sildqfnSEKRFYKIISIKHNLDRMNKEHQeiiki----------------------------------------- 1832
gi 39653635  1277 akh-svptvasTQQRRTQLFALRKMIRVMDKEHHgiladl---------------------------------------- 1315
gi 1705961    438 qkmtcridgcdTYKQLMKCIHELNRLNELHKQQLnilr------------------------------------------ 475
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 3882948        --------------------------------------------------------------------------------
gi 88595434       --------------------------------------------------------------------------------
gi 74906875       --------------------------------------------------------------------------------
gi 152148438  514 tellvlencgliqgqqqpeeplqelisplsvenrphddvqkrqtrssysqhrsennpeslqfssstlsrvqpsivethrs 593
gi 39984732       --------------------------------------------------------------------------------
gi 156630606      --------------------------------------------------------------------------------
gi 24418858       --------------------------------------------------------------------------------
gi 170593425      --------------------------------------------------------------------------------
gi 88595436       --------------------------------------------------------------------------------
gi 39653635       --------------------------------------------------------------------------------
gi 1705961        --------------------------------------------------------------------------------
                         330       340       350
                  ....*....|....*....|....*....|...
Feature 1                                          
gi 3882948    476 --------------------enlsFLNLPPLVV 488
gi 88595434  1486 --------------------qdrpDLEFPQLYL 1498
gi 74906875   479 --------------------dhkeSLSLPALFL 491
gi 152148438  594 vasllnqppilpiaiaairntfaqNCQLPTPML 626
gi 39984732  1316 -------------------rvfrsDLRFPELYV 1329
gi 156630606  343 -------------------rskwaVMQDHPLVL 356
gi 24418858   566 ------------------msdptsSEKLPALYK 580
gi 170593425  424 -----------------typqateKGALPDLYK 439
gi 88595436  1833 --------------------lkheNHYLPFSNL 1845
gi 39653635  1316 -------------------rvlrsDLRFPELYV 1329
gi 1705961    476 --------------------enlsFLNLPPLVV 488

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