1XB7,2PJL,1KV6,2PJL


Conserved Protein Domain Family
NR_LBD_ERR

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cd06946: NR_LBD_ERR 
Click on image for an interactive view with Cn3D
The ligand binding domain of estrogen receptor-related nuclear receptors
The ligand binding domain of estrogen receptor-related receptors (ERRs): The family of estrogen receptor-related receptors (ERRs), a subfamily of nuclear receptors, is closely related to the estrogen receptor (ER) family, but it lacks the ability to bind estrogen. ERRs can interfere with the classic ER-mediated estrogen signaling pathway, positively or negatively. ERRs share target genes, co-regulators and promoters with the estrogen receptor (ER) family. There are three subtypes of ERRs: alpha, beta and gamma. ERRs bind at least two types of DNA sequence, the estrogen response element and another site, originally characterized as SF-1 (steroidogenic factor 1) response element. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, ERR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD).
Statistics
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PSSM-Id: 132744
View PSSM: cd06946
Aligned: 12 rows
Threshold Bit Score: 320.081
Threshold Setting Gi: 74935853
Created: 19-Nov-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:1PJL; human ERR alpha binds synthetic inverse agonist, contacts at 4A
    View structure with Cn3D
  • Comment:agaonist: 1-cyclohexyl-N-[[1-(4-methylphenyl)indol-3-yl]methyl]methanamine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                           #  #   #  #  
1XB7_A        21 LVSHLLVVE--PEKLYAMPDpa-------------------------------------gPDGHLPAVATLCDLFDREIV 61
2PJL_B        21 LVSHLLVVE--PEKLYAMPDpa-------------------------------------gPDGHLPAVATLSDLFDREIV 61
gi 74935853  237 ILEVLNSYE--PDALSVQTPppqvhttsitndeassssgsiklessvvtpngtcifqnnnNNDPNEILSVLSDIYDKELV 314
gi 82196468  193 VVTLLLGAE--PEKVCAMPDpa-------------------------------------lPDSDIKALTTLCDLADRELV 233
gi 115394376 201 ILNTLLALEsqLDKLFASSDpf-------------------------------------lPDDDVKFRAAVSDLADRELV 243
gi 122049739 289 ILSHLLMAE--PDKLFAPHDhs-------------------------------------aTRSEISILTALCDLADRELV 329
gi 55741600  214 IVSHLLVAE--PEKIYAMPDpt-------------------------------------vPDSDIKALTTLCDLADRELV 254
gi 82199914  186 VVSHLLVAE--PDKLFAMPDpa-------------------------------------lPDGDLKYMSTLCDLADREIV 226
gi 110756963 223 MLEALAACE--PDMLQVSNIsh-------------------------------------tLDTDQRVLGQLSDLYDRELV 263
gi 212516486 226 ILEALSLNE--PDISVMAQDis-------------------------------------nADPAVRTLNILSDLYDQELV 266
1KV6_A         9 IVSHLLVAE--PEKIYAMPDpt-------------------------------------vPDSDIKALTTLCDLADRELV 49
2PJL_A        21 LVSHLLVVE--PEKLYAMPDpa-------------------------------------gPDGHLPAVATLSDLFDREIV 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                           #            #   #          ###              
1XB7_A        62 VTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDee-gARAAGLGELGAALLQLVRRL 140
2PJL_B        62 VTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDee-gARAAGLGELGAALLQLVRRL 140
gi 74935853  315 SVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNGKLCFATDVWMDeh-lAKECGYTEFYYHCVQIAQRM 393
gi 82196468  234 LNISWAKHIPGFSSLSLSDQMSLLQSAWMEILVLRVAFRSLPCDDRLLFADDYIMDae-qAKCAGLLELHTAILQLVRRY 312
gi 115394376 244 ITISWAKQVPGFTNLSLMDQMNLLQHSWLEILCLNLVFRSCPYNGHVCYAEDLRVPasmvETYNIPLELDSLTRKLCKKF 323
gi 122049739 330 VIIGWAKHIPGFTVLSLADQMALLQSAWMEVLVLGIVFRSLSRDGDLVIAEDFILDae-nCAEVGMVELYHYLNQLQRRL 408
gi 55741600  255 VIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYAEDYIMDed-qSKLAGLLDLNNAILQLVKKY 333
gi 82199914  227 IIISWAKNIPGFSSLSLSDQMSLLQSVWMEVLLLGVVFRSLPYEDEVVFAEDFVLDee-sSRSGRLTDLCSCVLHLVRKY 305
gi 110756963 264 GIIGWAKQIPGFSSLALNDQMRLLQSTWAEILTFSLAWRSMPNNGRLRFAQDFTLDer-lARECHCTELYTHCIQIVERL 342
gi 212516486 267 KIITWAKHIPGFLDLTLNDQMRLLQSTWAEILTLTVTYRSLPGTGELKFAADFSFDek-mARECGAMDIYQHCMHIVERQ 345
1KV6_A        50 VIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDed-qSKLAGLLDLNNAILQLVKKY 128
2PJL_A        62 VTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDee-gARAAGLGELGAALLQLVRRL 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
1XB7_A       141 QALRLEREEYVLLKALALANSDSVHiEDAEAVEQLREALHEALLEYEAgragpg-ggaerRRAGRLLLTLPLLRQTAGKV 219
2PJL_B       141 QALRLEREEYVLLKALALANSDSVHiEDAEAVEQLREALHEALLEYEAgragpg-ggaerRRAGRLLLTLPLLRQTAGKV 219
gi 74935853  394 ERISPRREEYYLLKALLLANCDILL-DDQSSLRAFRDTILNSLNDVVYllrh----ssavSHQQQLLLLLPSLRQADDIL 468
gi 82196468  313 RCMSLEREEFVTLKAIALANSDSMHiEDVEAVQGLQDALHEALLDYECvhhs-----edpRRAGKLIMTLPLLRQTSAKA 387
gi 115394376 324 TYLGVSKEEYVLLKAIILCNIDVVV-ETGETVRGLQDKLQDSLIECIKarhc-----gnpRRLGQLFLLLPPITHIKLLA 397
gi 122049739 409 KQLNFKKEEFVLMKAIALVNSDSLHvENHQTLRQLQDTLLQTLSDTVQstpsntattfafQRCGQLLLTLPLLRLAAVKA 488
gi 55741600  334 KSMKLEKEEFVTLKAIALANSDSMHiEDVEAVQKLQDVLHEALQDYEAgqhm-----edpRRAGKMLMTLPLLRQTSTKA 408
gi 82199914  306 RTLRVEKEEYVMLKALTLTNSDSVHiEDPDAVLRLRDALQEALSEYESgrhp-----eepCRDGKLLLTLPLLRQTAGRV 380
gi 110756963 343 QRLGLTREEYYVLKALILANSDARS-DEPQALYRFRDSILNSLSDCMAavrp----gqalRATQNMFLVLPSLRQVDGIV 417
gi 212516486 346 EKLNITKEEYYIIKALVLANSDVRI-DDLPPLKKLRDNILSALADCVAvlrp----nttsLHMNHLLLCLPALRQADYIN 420
1KV6_A       129 KSMKLEKEEFVTLKAIALANSDSMHiEDVEAVQKLQDVLHEALQDYEAgqhm-----edpRRAGKMLMTLPLLRQTSTKA 203
2PJL_A       141 QALRLEREEYVLLKALALANSDSVHiEDAEAVEQLREALHEALLEYEAgragpg-ggaerRRAGRLLLTLPLLRQTAGKV 219
                        250       260
                 ....*....|....*....|....*
Feature 1           #  # #                
1XB7_A       220 LAHFygVKLEGKVPMHKLFLEMLEA 244
2PJL_B       220 LAHFygVKLEGKVPMHKLFLEMLEA 244
gi 74935853  469 RRFWrgIARDEVITMKKLFLEMLEP 493
gi 82196468  388 VRHFcsIKQDGRVPMHKLFLELLEA 412
gi 115394376 398 KQFWfdLKKDGRVMMHKLFLEMLEA 422
gi 122049739 489 VHFFntVRQSGKVVLHKLFLEMLDA 513
gi 55741600  409 VQHFynIKLEGKVPMHKLFLEMLEA 433
gi 82199914  381 LQHFhaLREEGAVPMHKLFLEMLEA 405
gi 110756963 418 RRFWssVYRTGKVPMNKLFVEMLEA 442
gi 212516486 421 RRFWtaVHREGKVYMNKLFIEMLES 445
1KV6_A       204 VQHFynIKLEGKVPMHKLFLEMLEA 228
2PJL_A       220 LAHFygVKLEGKVPMHKLFLEMLEA 244

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